Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia.
Amyloid beta
Dementia
IBSP
NPPB
Proteomics
THBS2
Journal
Biological psychiatry global open science
ISSN: 2667-1743
Titre abrégé: Biol Psychiatry Glob Open Sci
Pays: United States
ID NLM: 9918227369306676
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
03
02
2022
revised:
13
04
2022
accepted:
27
04
2022
medline:
14
5
2022
pubmed:
14
5
2022
entrez:
31
7
2023
Statut:
epublish
Résumé
Plasma amyloid-β (Aβ) (Aβ We analyzed the association of these 3 plasma Aβ measures with 4638 circulating proteins among a subset of the participants of the Atherosclerosis Risk in Communities (ARIC) study (midlife: At midlife, of the 296 Aβ-associated proteins, 8 were associated with incident dementia from midlife and late life in the ARIC study, and NPPB, IBSP, and THBS2 were replicated in the AGES-Reykjavik Study. At late life, of the 34 Aβ-associated proteins, none were associated with incident dementia at midlife, and kidney function explained 10%, 12%, and 0.2% of the variance of Aβ This study identifies circulating proteins associated with plasma Aβ levels and incident dementia and informs peripheral factors associated with plasma Aβ levels.
Sections du résumé
Background
UNASSIGNED
Plasma amyloid-β (Aβ) (Aβ
Methods
UNASSIGNED
We analyzed the association of these 3 plasma Aβ measures with 4638 circulating proteins among a subset of the participants of the Atherosclerosis Risk in Communities (ARIC) study (midlife:
Results
UNASSIGNED
At midlife, of the 296 Aβ-associated proteins, 8 were associated with incident dementia from midlife and late life in the ARIC study, and NPPB, IBSP, and THBS2 were replicated in the AGES-Reykjavik Study. At late life, of the 34 Aβ-associated proteins, none were associated with incident dementia at midlife, and kidney function explained 10%, 12%, and 0.2% of the variance of Aβ
Conclusions
UNASSIGNED
This study identifies circulating proteins associated with plasma Aβ levels and incident dementia and informs peripheral factors associated with plasma Aβ levels.
Identifiants
pubmed: 37519456
doi: 10.1016/j.bpsgos.2022.04.005
pii: S2667-1743(22)00060-X
pmc: PMC10382706
doi:
Types de publication
Journal Article
Langues
eng
Pagination
490-499Informations de copyright
© 2022 The Authors.
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