Angiotensin II Type 1 Receptor Antibody-Mediated Kidney Rejection Unresponsive to Treatment.
apheresis therapy
at1r antibody
kidney allograft
non-hla antibody
renal transplant rejection
therapeutic plasma exchange (tpe)
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
accepted:
25
06
2023
medline:
31
7
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
Allograft rejection is a significant cause of renal transplant failure which needs prompt diagnosis and treatment for graft salvage. Angiotensin II type 1 receptor antibody-mediated rejection (AT1R-AMR) is increasingly being identified as the etiology of antibody-mediated rejection in kidney transplant recipients with allograft rejection but without detectable human leukocyte antigen (HLA) antibodies. While some reports have suggested that AT1R-AMR may be refractory to standard therapy, others have reported improvement or stabilization of graft function. We present two patients in which anti-rejection therapy including therapeutic plasma exchange was unable to salvage the allograft.
Identifiants
pubmed: 37519536
doi: 10.7759/cureus.41007
pmc: PMC10371875
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e41007Informations de copyright
Copyright © 2023, Allison et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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