Protective effect of fustin against adjuvant-induced arthritis through the restoration of proinflammatory response and oxidative stress.
Inflammatory cytokines
Arthritis
Freund’s adjuvant
Fustin
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2023
2023
Historique:
received:
18
01
2023
accepted:
19
05
2023
medline:
1
8
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
Rheumatoid arthritis causes irreparable damage to joints. The present research sought to check fustin's anti-arthritic efficacy against the complete Freund's adjuvant-induced arthritis paradigm in animals by altering the inflammatory response. In the rats, complete Freund's adjuvant was used to trigger arthritis and they received fustin at 50 and 100 mg/kg for 21 days. At regular intervals, the hind paw volume and arthritic score were assessed. After the trial period, hematological, antioxidant, pro-inflammatory cytokines, and other biochemical parameters were estimated. Fustin-treated rats showed the down-regulation of hind paw volume, arthritic score, and altered hematological parameters (TLC, DLC (neutrophil, lymphocyte, monocyte, eosinophil, basophil)). Furthermore, fustin significantly mitigates proinflammatory cytokine (reduced interleukin, tumor necrosis factor-a (TNF-
Identifiants
pubmed: 37520245
doi: 10.7717/peerj.15532
pii: 15532
pmc: PMC10386820
doi:
Substances chimiques
fustin
4994C1X19A
Freund's Adjuvant
9007-81-2
Cytokines
0
Tumor Necrosis Factor-alpha
0
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15532Informations de copyright
©2023 Alshehri et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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