NLRP3: a new therapeutic target in alcoholic liver disease.
NLRP3 inflammasome
alcohol
alcohol liver disease
epigenetics
interleukin 18
interleukin 1β
pro-caspase-1
pyroptosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
05
2023
accepted:
28
06
2023
medline:
23
10
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
The liver is in charge of a wide range of critical physiological processes and it plays an important role in activating the innate immune system which elicits the inflammatory events. Chronic ethanol exposure disrupts hepatic inflammatory mechanism and leads to the release of proinflammatory mediators such as chemokines, cytokines and activation of inflammasomes. The mechanism of liver fibrosis/cirrhosis involve activation of NLRP3 inflammasome, leading to the destruction of hepatocytes and subsequent metabolic dysregulation in humans. In addition, increasing evidence suggests that alcohol intake significantly modifies liver epigenetics, promoting the development of alcoholic liver disease (ALD). Epigenetic changes including histone modification, microRNA-induced genetic modulation, and DNA methylation are crucial in alcohol-evoked cell signaling that affects gene expression in the hepatic system. Though we are at the beginning stage without having the entire print of epigenetic signature, it is time to focus more on NLRP3 inflammasome and epigenetic modifications. Here we review the novel aspect of ALD pathology linking to inflammation and highlighting the role of epigenetic modification associated with NLRP3 inflammasome and how it could be a therapeutic target in ALD.
Identifiants
pubmed: 37520548
doi: 10.3389/fimmu.2023.1215333
pmc: PMC10374212
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1215333Subventions
Organisme : CSRD VA
ID : I01 CX002084
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA030407
Pays : United States
Informations de copyright
Copyright © 2023 Brahadeeswaran, Dasgupta, Manickam, Saraswathi and Tamizhselvi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Pharmacol Exp Ther. 2012 Feb;340(2):237-47
pubmed: 22025646
Immunol Rev. 2020 Sep;297(1):123-138
pubmed: 32770571
Int J Mol Sci. 2021 Jul 30;22(15):
pubmed: 34360999
Bioorg Med Chem Lett. 2020 Nov 1;30(21):127571
pubmed: 32980515
Nat Rev Gastroenterol Hepatol. 2021 Mar;18(3):151-166
pubmed: 33128017
Mol Neurodegener. 2016 Apr 16;11:28
pubmed: 27084336
Cell Biosci. 2022 Jan 3;12(1):1
pubmed: 34980273
J Cancer Res Clin Oncol. 2016 Feb;142(2):379-87
pubmed: 26314218
Alcohol Clin Exp Res. 2008 May;32(5):829-39
pubmed: 18336638
Pharmacol Ther. 2021 Nov;227:107880
pubmed: 33901504
Cell Physiol Biochem. 2018;49(2):798-815
pubmed: 30165354
J Biol Chem. 2014 Aug 15;289(33):22672-22691
pubmed: 24928512
Am J Dig Dis. 1968 Sep;13(9):783-91
pubmed: 5672729
J Neurooncol. 2007 Apr;82(2):133-9
pubmed: 17048097
Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67
pubmed: 24968059
J Neurosci. 2008 Apr 2;28(14):3729-37
pubmed: 18385331
Front Neurosci. 2012 May 30;6:77
pubmed: 22661925
J Nat Med. 2019 Mar;73(2):388-396
pubmed: 30617707
Alcohol Clin Exp Res. 2017 Apr;41(4):666-680
pubmed: 28111764
Am J Gastroenterol. 2005 Jun;100(6):1303-10
pubmed: 15929761
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
Exp Anim. 2021 Nov 10;70(4):488-497
pubmed: 34162771
World J Gastroenterol. 2009 Jun 7;15(21):2609-16
pubmed: 19496190
Oxid Med Cell Longev. 2016;2016:2183026
pubmed: 27127546
Cancer Res. 2006 Jun 15;66(12):6210-8
pubmed: 16778195
J Cell Physiol. 2019 Dec;234(12):23379-23387
pubmed: 31232472
Gut. 2020 Apr;69(4):764-780
pubmed: 31879281
Acta Pharmacol Sin. 2021 Feb;42(2):230-241
pubmed: 32770173
Cell Rep. 2020 Feb 11;30(6):1870-1882.e4
pubmed: 32049017
Hepatology. 2006 Feb;43(2 Suppl 1):S63-74
pubmed: 16447273
Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607
pubmed: 31399642
Front Immunol. 2019 Aug 27;10:2014
pubmed: 31507607
Biochem Biophys Res Commun. 2021 Jan 1;534:734-739
pubmed: 33213837
World J Gastroenterol. 2011 May 28;17(20):2456-64
pubmed: 21633650
Eur J Immunol. 2017 May;47(5):806-817
pubmed: 28247911
Expert Opin Investig Drugs. 2011 Aug;20(8):1151-8
pubmed: 21699444
Methods Enzymol. 2019;625:95-107
pubmed: 31455540
Cell Death Dis. 2021 Oct 15;12(10):949
pubmed: 34654807
Gut. 2019 Apr;68(4):708-720
pubmed: 29475852
Nat Med. 2015 Mar;21(3):248-55
pubmed: 25686105
Nature. 2006 Mar 9;440(7081):228-32
pubmed: 16407890
Oncogene. 2018 Feb 15;37(7):884-896
pubmed: 29059152
Biomed Res Int. 2016;2016:4323281
pubmed: 27366746
Nat Rev Genet. 2016 Aug;17(8):487-500
pubmed: 27346641
Front Physiol. 2022 Feb 21;13:831004
pubmed: 35264978
Nat Med. 2015 Mar;21(3):263-9
pubmed: 25686106
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
Trends Biochem Sci. 2016 Dec;41(12):1012-1021
pubmed: 27669650
J Biol Chem. 2004 Dec 3;279(49):51163-71
pubmed: 15383533
World J Gastroenterol. 2014 Oct 28;20(40):14652-9
pubmed: 25356028
Trends Genet. 2012 Oct;28(10):506-14
pubmed: 22824525
Immune Netw. 2018 Aug 13;18(4):e27
pubmed: 30181915
Gastroenterology. 2015 Jan;148(1):30-6
pubmed: 25447847
Liver Int. 2015 Mar;35(3):953-66
pubmed: 24750664
Chem Biol. 2010 May 28;17(5):471-82
pubmed: 20534345
Hepatology. 2020 Jan;71(1):306-333
pubmed: 31314133
J Cell Biol. 2009 Oct 5;187(1):61-70
pubmed: 19805629
J Immunol. 2017 Jan 15;198(2):937-949
pubmed: 27974453
J Biol Chem. 2002 Jun 14;277(24):21119-22
pubmed: 11967258
J Alzheimers Dis. 2019;68(1):255-265
pubmed: 30741672
Am J Gastroenterol. 2018 Feb;113(2):175-194
pubmed: 29336434
IUBMB Life. 2013 Oct;65(10):851-62
pubmed: 24078393
Front Immunol. 2022 May 30;13:896473
pubmed: 35707547
Alcohol Clin Exp Res. 2003 Dec;27(12):1979-86
pubmed: 14691386
Front Immunol. 2019 Oct 25;10:2538
pubmed: 31749805
J Inflamm Res. 2018 Dec 20;12:1-14
pubmed: 30588059
Biomedicines. 2021 Nov 04;9(11):
pubmed: 34829842
JACC Basic Transl Sci. 2018 Sep 19;3(5):604-624
pubmed: 30456333
Genet Epigenet. 2014 May 27;6:9-19
pubmed: 25512710
Clin Genitourin Cancer. 2007 Dec;5(7):422-6
pubmed: 18272023
World J Gastroenterol. 2006 Sep 7;12(33):5265-71
pubmed: 16981253
Clin Liver Dis. 2012 Nov;16(4):667-85
pubmed: 23101976
Immunity. 2012 Mar 23;36(3):401-14
pubmed: 22342844
Acta Pharm Sin B. 2021 Sep;11(9):2880-2899
pubmed: 34589402
Nat Rev Drug Discov. 2018 Aug;17(8):588-606
pubmed: 30026524
Int J Environ Res Public Health. 2010 Apr;7(4):1285-301
pubmed: 20617031
Alcohol Res. 2013;35(1):47-55
pubmed: 24313164
Lab Invest. 2021 Mar;101(3):369-380
pubmed: 33268842
Alcohol Res Health. 2003;27(3):209-19
pubmed: 15535449
J Hepatol. 2020 Apr;72(4):627-635
pubmed: 31760070
Nat Commun. 2018 Jun 29;9(1):2550
pubmed: 29959312
Cell Discov. 2020 Jun 9;6:36
pubmed: 32550001
Clin Transl Oncol. 2016 Mar;18(3):296-303
pubmed: 26260914
Annu Rev Nutr. 2012 Aug 21;32:343-68
pubmed: 22524187
Immunopharmacol Immunotoxicol. 2017 Aug;39(4):233-242
pubmed: 28555525
Hepatology. 2009 Feb;49(2):646-57
pubmed: 19177575
Exp Neurol. 2018 Apr;302:104-111
pubmed: 29339053
Biomed Res Int. 2016;2016:6495793
pubmed: 27092311
Front Immunol. 2018 Sep 25;9:2201
pubmed: 30319645
Int J Mol Med. 2017 Aug;40(2):263-270
pubmed: 28627645
J Allergy Clin Immunol. 1999 Jan;103(1 Pt 1):11-24
pubmed: 9893178
Biomed Pharmacother. 2021 Jun;138:111428
pubmed: 33667787
J Clin Invest. 2012 Oct;122(10):3476-89
pubmed: 22945633
J Leukoc Biol. 2015 Aug;98(2):249-56
pubmed: 25934928
Oncotarget. 2015 Sep 8;6(26):22706-23
pubmed: 26093088
J Biol Chem. 2004 Aug 6;279(32):33716-26
pubmed: 15155757
Nat Immunol. 2013 Dec;14(12):1247-55
pubmed: 24185614
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539
pubmed: 29378952
Biochem Pharmacol. 2004 Sep 15;68(6):1255-67
pubmed: 15313424
J Exp Med. 2017 Nov 6;214(11):3219-3238
pubmed: 29021150
Cancer Res. 2005 Jul 15;65(14):6305-11
pubmed: 16024632
Semin Hematol. 2005 Jul;42(3 Suppl 2):S9-16
pubmed: 16015507
J Hepatol. 2021 Jan;74(1):156-167
pubmed: 32763266
J Allergy Clin Immunol. 2017 Jan;139(1):202-211.e6
pubmed: 27394913
Nucleic Acids Res. 2012 Jan;40(1):116-31
pubmed: 21911366
Blood. 2012 Mar 15;119(11):2579-89
pubmed: 22262760
Transplantation. 2012 Aug 15;94(3):211-7
pubmed: 22790388
J Alcohol Drug Depend. 2017 Apr;5(2):
pubmed: 28730160
Int J Mol Sci. 2019 Jul 06;20(13):
pubmed: 31284572
Trends Immunol. 2019 Jan;40(1):66-80
pubmed: 30595189
J Natl Cancer Inst. 2003 Mar 5;95(5):399-409
pubmed: 12618505
Mol Med Rep. 2022 Feb;25(2):
pubmed: 34878155
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):764-777
pubmed: 29277324
Cell Metab. 2020 Mar 3;31(3):580-591.e5
pubmed: 32032542
Nat Immunol. 2020 Jul;21(7):736-745
pubmed: 32367036
Nat Chem Biol. 2019 Jun;15(6):556-559
pubmed: 31086327