Voluntary exercise does not always suppress lung cancer progression.
Cancer
Immunology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Aug 2023
18 Aug 2023
Historique:
received:
26
01
2023
revised:
11
05
2023
accepted:
03
07
2023
medline:
31
7
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the recruitment of natural killer (NK) cells to tumors. We asked if exercise suppresses lung cancer in an orthotopic model also. Single-housed C57Bl/6 male mice in cages with running wheels were tail vein-injected with LLC1.1 lung cancer cells, and lung tumor nodules were analyzed. Exercise did not affect lung cancer. Therefore, we also tested the effect of exercise on a subcutaneous LLC1 tumor and a tail vein-injected B16F10 melanoma model. Except for one case of excessive exercise, tumor progression was not influenced. Moderately exercising mice did not increase IL-6 or recruit NK cells to the tumor. Our data suggest that the exercise dose may dictate how efficiently the immune system is stimulated and controls tumor progression.
Identifiants
pubmed: 37520731
doi: 10.1016/j.isci.2023.107298
pii: S2589-0042(23)01375-5
pmc: PMC10374464
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107298Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
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