Examination of Homologies between COVID-19 Vaccines and Common Allergens: The Potential for T Cell-mediated Responses for Allergic Rhinitis and Asthma.
Allergy
COVID-19
Cross-reactivity
Rhinitis, allergic
Vaccines
mRNA
Journal
Infectious diseases & immunity
ISSN: 2693-8839
Titre abrégé: Infect Dis Immun
Pays: China
ID NLM: 9918556583806676
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
23
12
2021
medline:
31
7
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
ppublish
Résumé
As the SARS-CoV-2 virus shares relatively large protein sequences homologous to grass pollens, dust mites, and molds, our objective was to assess the potential overlap between the COVID-19 mRNA vaccines from Pfizer-BioNtech and Moderna and known allergens. We found 7 common allergens with potential for cross-reactivity with the Pfizer vaccine and 19 with the Moderna vaccine, including common grasses, molds, and dust mites. T-cell mediated antigen cross-reactivity between viruses and allergens is a relatively new area of study in clinical immunology; a discipline that may be particularly useful regarding the SARS-CoV-2 virus and the allergic response in humans. These results suggest that vaccination with the Pfizer-BioNtech and Moderna COVID-19 vaccines may contribute to T-cell cross-reactivity with allergens that impact allergic asthma and allergic rhinitis. Further research should assess the clinical implications of COVID-19 vaccination on the severity and symptomatology of the allergic disease, in addition to natural viral infection.
Identifiants
pubmed: 37520897
doi: 10.1097/ID9.0000000000000056
pii: IDI_220006
pmc: PMC9612419
doi:
Types de publication
Journal Article
Langues
eng
Pagination
282-284Informations de copyright
Copyright © 2022 The Chinese Medical Association, published by Wolters Kluwer Health, Inc.
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