Failures of Urge Suppression in Obsessive-Compulsive Disorder: Behavioral Modeling Using a Blink Suppression Task.
compulsivity
obsessive-compulsive disorder
sensory phenomena
Journal
Journal of obsessive-compulsive and related disorders
ISSN: 2211-3649
Titre abrégé: J Obsessive Compuls Relat Disord
Pays: England
ID NLM: 101580381
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
pmc-release:
01
07
2024
medline:
31
7
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
ppublish
Résumé
Many individuals with obsessive-compulsive disorder (OCD) report sensory-based urges (e.g. 'not-just-right experiences') in addition to, or instead of, concrete fear-based obsessions. These sensations may be comparable to normative "urges-for-action" (UFA), such as the urge to blink. While research has identified altered functioning of brain regions related to UFA in OCD, little is known about behavioral patterns of urge suppression in the disorder. Using an urge-to-blink task as a model for sensory-based urges, this study compared failures of urge suppression between OCD patients and controls by measuring eyeblinks during 60-second blocks of instructed blink suppression. Cox shared frailty models estimated the hazard of first blinks during each 60-second block and recurrent blinks following each initial erroneous blink. OCD patients demonstrated a higher hazard of first and recurrent blinks compared to controls, suggesting greater difficulty resisting repetitive sensory-based urges. Within OCD, relationships between task outcomes and symptom severity were inconsistent. Findings provide support for a deficit in delaying initial urge-induced actions and terminating subsequent actions in OCD, which is not clearly related to clinical heterogeneity. Elucidating the nature of behavioral resistance to urges is relevant for informing conceptualizations of obsessive-compulsive psychopathology and optimizing treatment outcomes.
Identifiants
pubmed: 37521712
doi: 10.1016/j.jocrd.2023.100824
pmc: PMC10373599
mid: NIHMS1919131
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111794
Pays : United States
Organisme : NIMH NIH HHS
ID : R33 MH107589
Pays : United States
Déclaration de conflit d'intérêts
Declaration of interest The authors declare no conflict of interest.
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