Retinal Thickness in Essential Tremor and Early Parkinson Disease: Exploring Diagnostic Insights.
Journal
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
ISSN: 1536-5166
Titre abrégé: J Neuroophthalmol
Pays: United States
ID NLM: 9431308
Informations de publication
Date de publication:
31 Jul 2023
31 Jul 2023
Historique:
pubmed:
31
7
2023
medline:
31
7
2023
entrez:
31
7
2023
Statut:
aheadofprint
Résumé
Essential tremor (ET) represents a heterogeneous condition which may overlap with Parkinson disease (PD) even at early stages, by sharing some subtle clinical aspects. Longstanding ET demonstrated also higher risk of developing PD, especially with a Tremor-dominant (TD-PD) phenotype. Therefore, differential diagnosis between ET and early PD could be quite challenging. Optical coherence tomography (OCT) has been recognized as a reliable tool to assess the retina as a proxy of neurodegeneration. We aimed to explore the possible role of retinal assessment in differential diagnosis between ET and early PD. Macular layers and peripapillary retinal nerve fiber layer (RNFL) thickness among ET, early PD, and healthy controls (HCs) were assessed using OCT. Forty-two eyes from 23 ET, 41 eyes from 21 early PD, and 33 eyes from 17 HCs were analyzed. Macular RNFL, ganglion cell layer, inner plexiform layer, and inner nuclear layer were thinner in PD as compared with ET and even more in HCs. Differences between ET and PD were more evident when considering the TD-PD subgroup, especially for RNFL. Among ET patients, thickness of the inner macular layers showed negative linear relationship with both age at onset and disease duration. Peripapillary temporal quadrant thinning was found in ET compared with HCs. Macular inner retina was thinner in patients with ET and early PD compared with HCs. These findings suggest that the retinal assessment may have a utility in the differential diagnosis between ET and PD.
Sections du résumé
BACKGROUND
BACKGROUND
Essential tremor (ET) represents a heterogeneous condition which may overlap with Parkinson disease (PD) even at early stages, by sharing some subtle clinical aspects. Longstanding ET demonstrated also higher risk of developing PD, especially with a Tremor-dominant (TD-PD) phenotype. Therefore, differential diagnosis between ET and early PD could be quite challenging. Optical coherence tomography (OCT) has been recognized as a reliable tool to assess the retina as a proxy of neurodegeneration. We aimed to explore the possible role of retinal assessment in differential diagnosis between ET and early PD.
METHODS
METHODS
Macular layers and peripapillary retinal nerve fiber layer (RNFL) thickness among ET, early PD, and healthy controls (HCs) were assessed using OCT.
RESULTS
RESULTS
Forty-two eyes from 23 ET, 41 eyes from 21 early PD, and 33 eyes from 17 HCs were analyzed. Macular RNFL, ganglion cell layer, inner plexiform layer, and inner nuclear layer were thinner in PD as compared with ET and even more in HCs. Differences between ET and PD were more evident when considering the TD-PD subgroup, especially for RNFL. Among ET patients, thickness of the inner macular layers showed negative linear relationship with both age at onset and disease duration. Peripapillary temporal quadrant thinning was found in ET compared with HCs.
CONCLUSIONS
CONCLUSIONS
Macular inner retina was thinner in patients with ET and early PD compared with HCs. These findings suggest that the retinal assessment may have a utility in the differential diagnosis between ET and PD.
Identifiants
pubmed: 37523235
doi: 10.1097/WNO.0000000000001959
pii: 00041327-990000000-00428
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the North American Neuro-Opthalmology Society.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Welton T, Cardoso F, Carr JA, et al. Essential tremor. Nat Rev Dis Primers. 2021;7:83.
Bhatia KP, Bain P, Bajaj N, et al. Tremor task force of the international Parkinson and movement disorder society. Consensus statement on the classification of tremors. From the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018;33:75–87.
Tarakad A, Jankovic J. Essential tremor and Parkinson's disease: exploring the relationship. Tremor Other Hyperkinet Mov (N Y). 2019;8:589.
Contrafatto D, Mostile G, Nicoletti A, et al. Single photon emission computed tomography striatal asymmetry index may predict dopaminergic responsiveness in Parkinson disease. Clin Neuropharmacol. 2011;34:71–73.
Chung SJ, Lee HS, Yoo HS, Lee YH, Lee PH, Sohn YH. Patterns of striatal dopamine depletion in early Parkinson disease: prognostic relevance. Neurology. 2020;95:e280–e290.
Satue M, Obis J, Rodrigo MJ, et al. Optical coherence tomography as a biomarker for diagnosis, progression, and prognosis of neurodegenerative diseases. J Ophthalmol. 2016;2016:8503859.
Cubo E, Tedejo RP, Rodriguez Mendez V, López Peña MJ, Trejo GabrielGalán YJM. Retina thickness in Parkinson's disease and essential tremor. Mov Disord. 2010;25:2461–2462.
Tak AZA, Şengül Y, Karadağ AS. Evaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration? Acta Neurol Belg. 2018;118:235–241.
Tugcu B, Melikov A, Yildiz GB, et al. Evaluation of retinal alterations in Parkinson disease and tremor diseases. Acta Neurol Belg. 2020;120:107–113.
Satue M, Castro L, Vilades E, et al. Ability of Swept-source OCT and OCT-angiography to detect neuroretinal and vasculature changes in patients with Parkinson disease and essential tremor. Eye (Lond). 2023;37:1314–1319.
Rascunà C, Russo A, Terravecchia C, et al. Retinal thickness and microvascular pattern in early Parkinson's disease. Front Neurol. 2020;11:533375.
Rascunà C, Cicero CE, Chisari CG, et al. Retinal thickness and microvascular pathway in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease. Parkinsonism Relat Disord. 2021;88:40–45.
Deuschl G, Bain P, Brin M. Consensus statement of the movement disorder society on tremor. Ad hoc Scientific Committee. Mov Disord. 1998;13(suppl 3):2–23.
Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015;30:1591–1601.
Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC. How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale. Mov Disord. 2013;28:668–670.
Aytulun A, Cruz-Herranz A, Aktas O, et al. APOSTEL 2.0 recommendations for reporting quantitative optical coherence tomography studies. Neurology. 2021;97:68–79.
Armstrong RA. Statistical guidelines for the analysis of data obtained from one or both eyes. Ophthalmic Physiol Opt. 2013;33:7–14.
Huang L, Wang C, Wang W, Wang Y, Zhang R. The specific pattern of retinal nerve fiber layer thinning in Parkinson's disease: a systematic review and meta-analysis. J Neurol. 2021;268:4023–4032.
Mostile G, Terranova R, Rascunà C, et al. Clinical-instrumental patterns of neurodegeneration in essential tremor: a data-driven approach. Parkinsonism Relat Disord. 2021;87:124–129.
Hopfner F, Ahlf A, Lorenz D, et al. Early- and late-onset essential tremor patients represent clinically distinct subgroups. Mov Disord. 2016;31:1560–1566.