An Alternative Thinking in Tumor Therapeutics: Living Yeast Armored with Silicate.

Humans Saccharomyces cerevisiae Carbon Dioxide Silicates Neoplasms / drug therapy Manganese
cancer therapy immune response living yeast silicate targeting

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
22 08 2023
Historique:
medline: 23 8 2023
pubmed: 31 7 2023
entrez: 31 7 2023
Statut: ppublish

Résumé

A hybrid platform, constructed via the surface "armoring" of living yeasts by a manganese silicate compound (MS@Yeast), is investigated for combinational cancer treatment. The intrinsic characteristics of living yeasts, in both acidophilic and anaerobic conditions, empower the hybrid platform with activated selected colonization in tumors. While silicate particles are delivered in a targeting manner, yeast fermentation occurs at the cancerous region, inducing both alcohol and CO

Identifiants

DOI: 10.1021/acsnano.3c06311 PMID: 37523324
pubmed: 37523324
doi: 10.1021/acsnano.3c06311
doi:

Substances chimiques

Carbon Dioxide 142M471B3J
Silicates 0
Manganese 42Z2K6ZL8P

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16264-16273

Auteurs

Qiang Chu (Q)

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.
Tea Research Institute, Zhejiang University, Hangzhou 310058, People's Republic of China.

Congkun Xie (C)

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.

Guodong Cao (G)

Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, People's Republic of China.

Zefeng Hu (Z)

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.

Feiyu Li (F)

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.

Yike Fu (Y)

ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, People's Republic of China.

Gaorong Han (G)

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.

Xiang Li (X)

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.
ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, People's Republic of China.
ORCID: 0000-0002-4675-5367

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An Alternative Thinking in Tumor Therapeutics:...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › An Alternative Thinking in Tumor Therapeutics:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Dioxyde de carbone › An Alternative Thinking in Tumor Therapeutics:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Acide silicique › Silicates › An Alternative Thinking in Tumor Therapeutics:...
questionsmedicales.fr › Tumeurs › An Alternative Thinking in Tumor Therapeutics:...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Manganèse › An Alternative Thinking in Tumor Therapeutics:...