Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated

Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Longevity Sulfides / metabolism Hydrogen Sulfide / metabolism Mitochondria / metabolism Oxidative Stress GATA Transcription Factors / metabolism
H2S health span longevity mitochondria transcriptomics

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
08 08 2023
Historique:
medline: 11 8 2023
pubmed: 31 7 2023
entrez: 31 7 2023
Statut: ppublish

Résumé

Living longer without simultaneously extending years spent in good health ("health span") is an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide (H

Identifiants

DOI: 10.1073/pnas.2216141120 PMID: 37523525 PMC: PMC10410709
pubmed: 37523525
doi: 10.1073/pnas.2216141120
pmc: PMC10410709
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Sulfides 0
Hydrogen Sulfide YY9FVM7NSN
elt-3 protein, C elegans 0
GATA Transcription Factors 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2216141120

Subventions

Organisme : Medical Research Council
ID : MR/M022706/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S002626/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015894/1
Pays : United Kingdom

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Auteurs

Adriana Raluca Vintila (AR)

Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
ORCID: 0000-0001-7956-7904

Luke Slade (L)

Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
ORCID: 0000-0001-7660-7392

Michael Cooke (M)

Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research, Nottingham Biomedical Research Center, School of Medicine, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom.
ORCID: 0000-0003-2081-3466

Craig R G Willis (CRG)

School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, United Kingdom.

Roberta Torregrossa (R)

University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
ORCID: 0000-0002-1809-7029

Mizanur Rahman (M)

Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409.

Taslim Anupom (T)

Department of Electrical Engineering, Texas Tech University, Lubbock, TX 74909.

Siva A Vanapalli (SA)

Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409.
ORCID: 0000-0001-6036-1949

Christopher J Gaffney (CJ)

Lancaster University Medical School, Lancaster University, Lancaster LA1 4YW, United Kingdom.
ORCID: 0000-0001-7990-2792

Nima Gharahdaghi (N)

University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.

Csaba Szabo (C)

Chair of Pharmacology, Section of Medicine, University of Fribourg, Fribourg CH-1700, Switzerland.
ORCID: 0000-0003-3110-4235

Nathaniel J Szewczyk (NJ)

Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research, Nottingham Biomedical Research Center, School of Medicine, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom.
Ohio Musculoskeletal and Neurologic Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701.
ORCID: 0000-0003-4425-9746

Matthew Whiteman (M)

University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
ORCID: 0000-0002-6583-6779

Timothy Etheridge (T)

Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, United Kingdom.
ORCID: 0000-0002-3588-8711

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Mitochondrial sulfide promotes life span and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription GATA › Mitochondrial sulfide promotes life span and...