Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.


Journal

Nature structural & molecular biology
ISSN: 1545-9985
Titre abrégé: Nat Struct Mol Biol
Pays: United States
ID NLM: 101186374

Informations de publication

Date de publication:
09 2023
Historique:
received: 30 11 2021
accepted: 26 06 2023
medline: 14 9 2023
pubmed: 1 8 2023
entrez: 31 7 2023
Statut: ppublish

Résumé

The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the nucleus via binding of its second and third BIR domains, BIRC2

Identifiants

pubmed: 37524969
doi: 10.1038/s41594-023-01044-1
pii: 10.1038/s41594-023-01044-1
pmc: PMC10702411
mid: NIHMS1945045
doi:

Substances chimiques

LCL161 0
Inhibitor of Apoptosis Proteins 0
Thiazoles 0
BIRC2 protein, human EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1265-1274

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM125195
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA268440
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH128021
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068616
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104015
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204020
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151334
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067664
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI106716
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG067664
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA252707
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA255506
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135671
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068632
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Adam H Tencer (AH)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

Yucong Yu (Y)

Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.

Sebastien Z Causse (SZ)

Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France.

Grant R Campbell (GR)

Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.

Brianna J Klein (BJ)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

Hongwen Xuan (H)

Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.

Jessy Cartier (J)

Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France.

Mark A Miles (MA)

Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.

Nitika Gaurav (N)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

Aymeric Zadoroznyj (A)

Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France.

Tina A Holt (TA)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

Hong Wen (H)

Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.

Christine J Hawkins (CJ)

Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.

Stephen A Spector (SA)

Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. saspector@health.ucsd.edu.
Rady Children's Hospital, San Diego, CA, USA. saspector@health.ucsd.edu.

Laurence Dubrez (L)

Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France. laurence.dubrez@u-bourgogne.fr.

Xiaobing Shi (X)

Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA. xiaobing.shi@vai.org.

Tatiana G Kutateladze (TG)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. tatiana.kutateladze@cuanschutz.edu.

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Classifications MeSH