Screening of Phyllanthus niruri Plant Active Constituents for Anticancer and Antifungal Activity by Insilico Methods.
Anticancer activity
Antifungal
Molecular docking
Phyllanthus niruri
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
2
8
2023
pubmed:
1
8
2023
entrez:
31
7
2023
Statut:
ppublish
Résumé
A large genus of shrubs, trees, and rare plants belonging to the Euphorbiaceae family, Phyllanthus contains 600-700 species. The Phyllanthus niruri (L.) species is a tiny, erect annual herb that can reach heights of 30-40 cm. Its 7-12 cm long, sessile, alternating leaves are native to the Amazon rainforest, but they can also be found in other tropical regions such as South East Asia, Southern India, America, China, and the islands of the Indian Ocean. Phyllanthus contains many classes of alkaloids, steroids, flavonoids, lignin, polyphenols, and lipids. Numerous activities of the plant have been studied, including antidepressant (Wasnik et al., Int J Pharm Sci Rev Res, 6:26-29, 2014), anticancer (Sayuti et al. Studies, 10:17, 2020), anti-inflammatory, antinociceptive (Porto et al., Revista Brasileira de Farmacognosia, 23:138-144, 2013), analgesic (Bhat et al., Pharm Res, 7:378, 2015), antiarthritic (Mali et al., Biomed Aging Pathol, 1:185-190, 2011), immunomodulatory, antibacterial, antifungal (Shilpa et al., Environm Dis, 3:63, 2018), antidiabetic (Kumar et al., Biomed Pharm J, 12:57-63, 2019), antiulcer (Mostofa et al., BMC Complement Altern Med, 17:1-10, 2017), antiviral (Wahyuni et al., Malays Appl Biol, 48:105-111, 2019), antiplasmodial (Ifeoma et al., Asian Pacific J Trop Med, 6:169-175, 2013), anticonvulsant (Amaechina and Omogbai, Nig J Nat Prod Med, 17:61-65, 2013), and hepato human cytochrome P450 CYP17A1 in association with abiraterone [PDB ID: 3RUK] plant extracts. New selective androgen receptor modulators were synthesized, and they were biologically evaluated (SARMs) (Micah et al., J Veter Med Anim Health 5(1):8-15, 2013, Rusmana et al., Indonesian Biomed J 9(2):84-90, 2017, Al Zarzour et al., Nutrients 10(8):1057, 2018, Khanna J Ethnopharmacol 82(1):19-22, 2002). In the present study [PDB ID: 3RUK,5T8E] with anticancer and [PDB ID: 6F0E,1EA1] with antifungal activities were used for docking study. In this study fluconazole's antifungal activity and dacarbazine's anticancer activity were used as benchmarks for molecular docking with Schrodinger 13.0 to compare the activity of Phyllanthus niruri's active constituents.
Identifiants
pubmed: 37525037
doi: 10.1007/978-3-031-31978-5_10
doi:
Substances chimiques
Plant Extracts
0
Antifungal Agents
0
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-132Informations de copyright
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Warake, R. A., Jarag, R. J., Dhavale, R. P., Jarag, R. R., & Lohar, N. S. (2021). Evaluation of in vitro antioxidant, anticancer activities and molecular docking studies of Capparis zeylanica Linn. leaves. Future Journal of Pharmaceutical Sciences, 7(1), 1–12.
doi: 10.1186/s43094-021-00218-2
Twomey, J. D., & Zhang, B. (2021). Cancer immunotherapy update: FDA-approved checkpoint inhibitors and companion diagnostics. The AAPS Journal, 23(2), 1–11.
doi: 10.1208/s12248-021-00574-0
Fridlender, M., Kapulnik, Y., & Koltai, H. (2015). Plant derived substances with anti-cancer activity: from folklore to practice. Frontiers in plant science, 6, 799.
doi: 10.3389/fpls.2015.00799
pubmed: 26483815
pmcid: 4589652
Turecka, K., Chylewska, A., Kawiak, A., & Waleron, K. F. (2018). Antifungal activity and mechanism of action of the Co (III) coordination complexes with diamine chelate ligands against reference and clinical strains of Candida spp. Frontiers in microbiology, 9, 1594.
doi: 10.3389/fmicb.2018.01594
pubmed: 30072969
pmcid: 6058090
Can, N. Ö., Acar Çevik, U., Sağlık, B. N., Levent, S., Korkut, B., Özkay, Y., … & Koparal, A. S. (2017). Synthesis, molecular docking studies, and antifungal activity evaluation of new benzimidazole-triazoles as potential lanosterol 14α-demethylase inhibitors. Journal of Chemistry, 2017.
Scorzoni, L., de Paula e Silva, A. C., Marcos, C. M., Assato, P. A., de Melo, W. C., de Oliveira, H. C., … & Fusco-Almeida, A. M. (2017). Antifungal therapy: new advances in the understanding and treatment of mycosis. Frontiers in microbiology, 8, 36.
Al-Soud, Y. A., Alhelal, K. A., Saeed, B. A., Abu-Qatouseh, L., Al-Soud, H. H., Al-Ahmad, A. A. H., … & Qawasmeh, R. A. (2021). Synthesis, anticancer activity and molecular docking studies of new 4-nitroimidazole derivatives. Arkivoc, 8, 296–309.
Luo, B., Li, D., Zhang, A. L., & Gao, J. M. (2018). Synthesis, antifungal activities and molecular docking studies of benzoxazole and benzothiazole derivatives. Molecules, 23(10), 2457.
doi: 10.3390/molecules23102457
pubmed: 30257495
pmcid: 6222379
Can, N. Ö., Acar Çevik, U., Sağlık, B. N., Levent, S., Korkut, B., Özkay, Y., … & Koparal, A. S. (2017). Synthesis, molecular docking studies, and antifungal activity evaluation of new benzimidazole-triazoles as potential lanosterol 14α-demethylase inhibitors. Journal of Chemistry, 2017.
Wasnik, U., Singh, V., & Alli, M. (2014). Evaluation of the antidepressant effects of Phyllanthus amarus in Mice. International Journal of Pharmaceutical Sciences Review and Research, 6, 26–29.
Sayuti, M., Riwanto, I., Boediono, B. P., & Akbar, T. I. S. (2020). Anticancer Activity of Phyllanthus Niruri Linn Extract in Colorectal Cancer Patients: A phase II Clinical Trial. Studies, 10, 17.
Porto, C. R., Soares, L. A., Souza, T. P., Petrovick, P. R., Lyra, I. L., Júnior, R. F. A., … & Guerra, G. C. (2013). Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract. Revista Brasileira de Farmacognosia, 23(1), 138–144.
Bhat, S. S., Hegde, K. S., Chandrashekhar, S., Rao, S. N., & Manikkoth, S. (2015). Preclinical screening of Phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity. Pharmacognosy Research, 7(4), 378.
doi: 10.4103/0974-8490.159577
pmcid: 4660518
Mali, S. M., Sinnathambi, A., Kapase, C. U., Bodhankar, S. L., & Mahadik, K. R. (2011). Anti-arthritic activity of standardised extract of Phyllanthus amarus in Freund’s complete adjuvant induced arthritis. Biomedicine & Aging Pathology, 1(3), 185–190.
doi: 10.1016/j.biomag.2011.09.004
Shilpa, V. P., Muddukrishnaiah, K., Thavamani, B. S., Dhanapal, V., Arathi, K. N., Vinod, K. R., & Sreeranjini, S. R. (2018). In vitro immunomodulatory, antifungal, and antibacterial screening of Phyllanthus niruri against to human pathogenic microorganisms. Environmental Disease, 3(3), 63.
doi: 10.4103/ed.ed_9_18
Kumar, A., Rana, A. K., Singh, A., & Singh, A. (2019). Effect of methanolic extract of Phyllanthus niruri on leptin level in animal model of diabetes Mellitus. Biomedical and Pharmacology Journal, 12(1), 57–63.
doi: 10.13005/bpj/1613
Mostofa, R., Ahmed, S., Begum, M., Rahman, S., Begum, T., Ahmed, S. U., … & Begum, R. (2017). Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L.(Euphorbiaceae) leaves in experimental rats. BMC complementary and alternative medicine, 17(1), 1–10.
Wahyuni, T. S., Azmi, D., Permanasari, A. A., Adianti, M., Tumewu, L., Widiandani, T., … & Hotta, H. (2019). Anti-viral activity of Phyllanthus niruri against hepatitis C virus. Malaysian Applied Biology, 48(3), 105–111.
Ifeoma, O., Samuel, O., Itohan, A. M., & Adeola, S. O. (2013). Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pacific journal of tropical medicine, 6(3), 169–175.
doi: 10.1016/S1995-7645(13)60018-8
pubmed: 23375028
Amaechina, F. C., & Omogbai, E. K. I. (2013). Some Central Nervous System Effects of the aqueous Extract of the Leaves of Phyllanthus Amarus Schum, (Euphorbiaceae). Nigerian Journal of Natural Products and Medicine, 17, 61–65.
doi: 10.4314/njnpm.v17i1.5
Micah, S. M., Isaac, M. A., & Loveth, I. N. I. (2013). Hepatoprotective effect of Phyllanthus niruri aqueous extract in acetaminophen sub-acutec exposure rabbits. Journal of Veterinary Medicine and Animal Health, 5(1), 8–15.
Rusmana, D., Wahyudianingsih, R., Elisabeth, M., Balqis, B., Maesaroh, M., & Widowati, W. (2017). Antioxidant activity of Phyllanthus niruri extract, rutin and quercetin. The Indonesian Biomedical Journal, 9(2), 84–90.
doi: 10.18585/inabj.v9i2.281
Al Zarzour, R. H., Alshawsh, M. A., Asif, M., Al-Mansoub, M. A., Mohamed, Z., Ahmad, M., … & Yam, M. F. (2018). Adipocytokine regulation and antiangiogenic activity underlie the molecular mechanisms of therapeutic effects of Phyllanthus niruri against non-alcoholic fatty liver disease. Nutrients, 10(8), 1057.
Khanna, A. K., Rizvi, F., & Chander, R. (2002). Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. Journal of ethnopharmacology, 82(1), 19–22.
doi: 10.1016/S0378-8741(02)00136-8
pubmed: 12169400