The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial.
Inflammatory bowel disease
Interleukin
Selenium
Ulcerative colitis
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
13
10
2022
accepted:
14
07
2023
medline:
30
10
2023
pubmed:
1
8
2023
entrez:
31
7
2023
Statut:
ppublish
Résumé
Selenium (Se) supplementation may help reduce inflammation and disease activity in ulcerative colitis (UC) patients. We investigated the therapeutic effects of Se administration in cases with mild-to-moderate active UC. A multicenter, double-blind, randomized clinical trial (RCT) was conducted on 100 cases with active mild-to-moderate UC. The patients were randomly allocated to be given an oral selenomethionine capsule (200 mcg/day, n = 50) or a placebo capsule (n = 50) for 10 weeks. The primary outcome was defined as disease activity via the Simple Clinical Colitis Activity Index (SCCAI), and secondary outcomes were measured at the end of the study. After 10 weeks, the SCCAI score's mean was reduced in the Se group (P < 0.001). At the end of the intervention, clinical improvement (decline of 3 ≥ score from baseline score) was observed in 19 patients (38%) of the Se group and 3 patients (6%) of the placebo group. The patients with clinical remission (defined as SCCAI ≤ 2) were assigned in the Se group (P = 0.014). The Se group's quality of life and Se serum levels were enhanced at the end of the study (P < 0/001). In the Se group, the mean concentration of interleukin-17 decreased (P < 0/001). However, the levels of interleukin-10 showed no considerable change between the two groups in the 10th week (P = 0.23). Se supplementation as add-on therapy with medical management induced remission and improved the quality of life in patients with active mild-to-moderate UC. IRCT20091114002709N51; 2020-04-13.
Identifiants
pubmed: 37525068
doi: 10.1007/s00394-023-03214-9
pii: 10.1007/s00394-023-03214-9
doi:
Substances chimiques
Selenium
H6241UJ22B
Biomarkers
0
Banques de données
IRCT
['IRCT20091114002709N51']
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3125-3134Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Références
Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K (2019) Immune response and inflammatory pathway of ulcerative colitis. J Basic Clin Physiol Pharmacol 30(1):1–10
doi: 10.1515/jbcpp-2018-0036
Kaser A, Zeissig S, Blumberg RS (2010) Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future? Dig Dis 28(3):395–405
pubmed: 20926863
pmcid: 2980818
doi: 10.1159/000320393
Zhang Y-Z, Li Y-Y (2014) Inflammatory bowel disease: pathogenesis. World J Gastroenterol: WJG 20(1):91
pubmed: 24415861
pmcid: 3886036
doi: 10.3748/wjg.v20.i1.91
Hisamatsu T, Kanai T, Mikami Y, Yoneno K, Matsuoka K, Hibi T (2013) Immune aspects of the pathogenesis of inflammatory bowel disease. Pharmacol Ther 137(3):283–297
pubmed: 23103332
doi: 10.1016/j.pharmthera.2012.10.008
de Moura MSB, Soares NRM, Barros SÉdL, de Pinho FA, Silva TMC, Bráz DC, Vieira EC, Lima MM, Parente JML, Marreiro DdN, da Silva AS, Nogueira NdN (2020) Zinc gluconate supplementation impacts the clinical improvement in patients with ulcerative colitis. Biometals 33(1):15–27. https://doi.org/10.1007/s10534-019-00225-0
doi: 10.1007/s10534-019-00225-0
pubmed: 31956928
Yang X, Yan Y, Li J, Tang Z, Sun J, Zhang H, Hao S, Wen A, Liu L (2016) Protective effects of ethanol extract from Portulaca oleracea L on dextran sulphate sodium-induced mice ulcerative colitis involving anti-inflammatory and antioxidant. Am J Translatl Res 8(5):2138
Cholapranee A, Hazlewood GS, Kaplan GG, Peyrin-Biroulet L, Ananthakrishnan AN (2017) Systematic review with meta-analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn’s disease and ulcerative colitis controlled trials. Aliment Pharmacol Ther 45(10):1291–1302
pubmed: 28326566
pmcid: 5395316
doi: 10.1111/apt.14030
Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A (2015) Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study. Arch Med Res 46(4):280–285
pubmed: 26002728
doi: 10.1016/j.arcmed.2015.05.005
Rutgeerts P (2002) A critical assessment of new therapies in inflammatory bowel disease. J Gastroenterol Hepatol 17:S176–S185
pubmed: 12000604
doi: 10.1046/j.1440-1746.17.s1.1.x
Yao J, Wang J-Y, Liu L, Li Y-X, Xun A-Y, Zeng W-S, Jia C-H, Wei X-X, Feng J-L, Zhao L (2010) Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis. Arch Med Res 41(4):288–294
pubmed: 20637373
doi: 10.1016/j.arcmed.2010.05.002
Benstoem C, Goetzenich A, Kraemer S, Borosch S, Manzanares W, Hardy G, Stoppe C (2015) Selenium and its supplementation in cardiovascular disease—what do we know? Nutrients 7(5):3094–3118
pubmed: 25923656
pmcid: 4446741
doi: 10.3390/nu7053094
Sang L, Chang B, Zhu J, Yang F, Li Y, Jiang X, Sun X, Lu C, Wang D (2016) Dextran sulfate sodium-induced acute experimental colitis in C57BL/6 mice is mitigated by selenium. Int Immunopharmacol 39:359–368
pubmed: 27533281
doi: 10.1016/j.intimp.2016.07.034
Short SP, Pilat JM, Williams CS (2018) Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease. Free Radical Biol Med 127:26–35
doi: 10.1016/j.freeradbiomed.2018.05.066
Poursadegh F, Ahadi M, Vosoughinia H, Salehi M, Namdar AB, Farzanehfar MR, Memar B, Ziaolhagh R (2018) A STROBE compliant observational study on trace elements in patients with ulcerative colitis and their relationship with disease activity. Medicine 97(52):e13523
pubmed: 30593128
pmcid: 6314770
doi: 10.1097/MD.0000000000013523
Kaushal N, Kudva AK, Patterson AD, Chiaro C, Kennett MJ, Desai D, Amin S, Carlson BA, Cantorna MT, Prabhu KS (2014) Crucial role of macrophage selenoproteins in experimental colitis. J Immunol 193(7):3683–3692
pubmed: 25187657
doi: 10.4049/jimmunol.1400347
Sang L-X, Chang B, Zhu J-F, Yang F-L, Li Y, Jiang X-F, Wang D-N, Lu C-L, Sun X (2017) Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4 (+) CD25 (+) regulatory T-cell responses. World J Gastroenterol 23(21):3850
pubmed: 28638225
pmcid: 5467071
doi: 10.3748/wjg.v23.i21.3850
Zhu C, Zhang S, Song C, Zhang Y, Ling Q, Hoffmann PR, Li J, Chen T, Zheng W, Huang Z (2017) Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation. J Nanobiotechnol 15(1):20
doi: 10.1186/s12951-017-0252-y
Stedman J, Spyrou N, Millar A, Altaf W, Akanle O, Rampton D (1997) Selenium supplementation in the diets of patients suffering from ulcerative colitis. J Radioanal Nucl Chem 217(2):189–191
doi: 10.1007/BF02034441
Speckmann B, Steinbrenner H (2014) Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis. Inflamm Bowel Dis 20(6):1110–1119
pubmed: 24694793
Khazdouz M, Daryani NE, Alborzi F, Jazayeri MH, Farsi F, Hasani M, Heshmati J, Shidfar F (2020) Effect of selenium supplementation on expression of SIRT1 and PGC-1α genes in ulcerative colitis patients: a double blind randomized clinical trial. Clin Nutr Res 9(4):284
pubmed: 33204668
pmcid: 7644364
doi: 10.7762/cnr.2020.9.4.284
Gholamrezaei A, Haghdani S, Shemshaki H, Tavakoli H, Emami MH (2011) Linguistic validation of the inflammatory bowel disease questionnaire-short form (IBDQ-9) in Iranian population. J Isfahan Med School 28(123):1850–1859
Lang A, Salomon N, Wu JC, Kopylov U, Lahat A, Har-Noy O, Ching JY, Cheong PK, Avidan B, Gamus D (2015) Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol 13(8):1444-1449.e1441
pubmed: 25724700
doi: 10.1016/j.cgh.2015.02.019
Shapira S, Leshno A, Katz D, Maharshak N, Hevroni G, Jean-David M, Kraus S, Galazan L, Aroch I, Kazanov D (2018) Of mice and men: a novel dietary supplement for the treatment of ulcerative colitis. Therapeut Adv Gastroenterol 11:1756283X17741864
doi: 10.1177/1756283X17741864
Fairweather-Tait SJ, Collings R, Hurst R (2010) Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr 91(5):1484S-1491S
pubmed: 20200264
doi: 10.3945/ajcn.2010.28674J
Hardy G, Hardy I, Manzanares W (2012) Selenium supplementation in the critically ill. Nutr Clin Pract 27(1):21–33
pubmed: 22307489
doi: 10.1177/0884533611434116
Hadrup N, Ravn-Haren G (2023) Toxicity of repeated oral intake of organic selenium, inorganic selenium, and selenium nanoparticles: a review. J Trace Elements Med Biol 79:127235
doi: 10.1016/j.jtemb.2023.127235
Hariharan S, Dharmaraj S (2020) Selenium and selenoproteins: it’s role in regulation of inflammation. Inflammopharmacology 28:667–695
pubmed: 32144521
pmcid: 7222958
doi: 10.1007/s10787-020-00690-x
Hoffmann PR, Berry MJ (2008) The influence of selenium on immune responses. Mol Nutr Food Res 52(11):1273–1280
pubmed: 18384097
pmcid: 3723386
doi: 10.1002/mnfr.200700330
Huang Z, Rose AH, Hoffmann PR (2012) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 16(7):705–743
pubmed: 21955027
pmcid: 3277928
doi: 10.1089/ars.2011.4145
Bitiren M, Karakilcik AZ, Zerin M, Ozardalı I, Selek S, Nazlıgül Y, Ozgonul A, Musa D, Uzunkoy A (2010) Protective effects of selenium and vitamin E combination on experimental colitis in blood plasma and colon of rats. Biol Trace Elem Res 136(1):87–95
pubmed: 19774348
doi: 10.1007/s12011-009-8518-3
Tirosh O, Levy E, Reifen R (2007) High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon. Nutrition 23(11):878–886
pubmed: 17936198
doi: 10.1016/j.nut.2007.08.019
Kretz-Remy C, Arrigo A-P (2001) Selenium: A key element that controls NF-κB activation and IκBα half life. BioFactors 14(1–4):117–125
pubmed: 11568448
doi: 10.1002/biof.5520140116
Xia Y, Shen S, Verma IM (2014) NF-κB, an active player in human cancers. Cancer Immunol Res 2(9):823–830. https://doi.org/10.1158/2326-6066.cir-14-0112
doi: 10.1158/2326-6066.cir-14-0112
pubmed: 25187272
pmcid: 4155602
Mehta RS, Nishihara R, Cao Y, Song M, Mima K, Qian ZR, Nowak JA, Kosumi K, Hamada T, Masugi Y, Bullman S, Drew DA, Kostic AD, Fung TT, Garrett WS, Huttenhower C, Wu K, Meyerhardt JA, Zhang X, Willett WC, Giovannucci EL, Fuchs CS, Chan AT, Ogino S (2017) Association of dietary patterns with risk of colorectal cancer subtypes classified by Fusobacterium nucleatum in tumor tissue. JAMA Oncol 3(7):921–927. https://doi.org/10.1001/jamaoncol.2016.6374
doi: 10.1001/jamaoncol.2016.6374
pubmed: 28125762
pmcid: 5502000
Prabhu KS, Zamamiri-Davis F, Stewart JB, Thompson JT, Sordillo LM, Reddy CC (2002) Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-κB in up-regulation. Biochem J 366(1):203–209
pubmed: 12006087
pmcid: 1222757
doi: 10.1042/bj20020256
Zamamiri-Davis F, Lu Y, Thompson JT, Prabhu KS, Reddy PV, Sordillo LM, Reddy CC (2002) Nuclear factor-κB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency. Free Rad Biol Med 32(9):890–897
pubmed: 11978490
doi: 10.1016/S0891-5849(02)00775-X
Gandhi UH, Kaushal N, Ravindra KC, Hegde S, Nelson SM, Narayan V, Vunta H, Paulson RF, Prabhu KS (2011) Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) γ. J Biol Chem 286(31):27471–27482
pubmed: 21669866
pmcid: 3149340
doi: 10.1074/jbc.M111.260547
Vunta H, Davis F, Palempalli UD, Bhat D, Arner RJ, Thompson JT, Peterson DG, Reddy CC, Prabhu KS (2007) The anti-inflammatory effects of selenium are mediated through 15-deoxy-Δ12, 14-prostaglandin J2 in macrophages. J Biol Chem 282(25):17964–17973
pubmed: 17439952
doi: 10.1074/jbc.M703075200
Cao Y-Z, Reddy CC, Sordillo LM (2000) Altered eicosanoid biosynthesis in selenium-deficient endothelial cells. Free Radical Biol Med 28(3):381–389
doi: 10.1016/S0891-5849(99)00251-8
De Silva PS, Olsen A, Christensen J, Schmidt EB, Overvaad K, Tjonneland A, Hart AR (2010) An association between dietary arachidonic acid, measured in adipose tissue, and ulcerative colitis. Gastroenterology 139(6):1912–1917
pubmed: 20950616
doi: 10.1053/j.gastro.2010.07.065
Sharon P, Ligumsky M, Rachmilewitz D, Zor U (1978) Role of prostaglandins in ulcerative colitis: enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 75(4):638–640
pubmed: 30669
doi: 10.1016/S0016-5085(19)31672-5
Wiercińska-Drapało A, Flisiak R, Prokopowicz D (2001) Plasma and mucosal prostaglandin E2 as a surrogate marker of ulcerative colitis activity. Roczniki Akademii Medycznej w Bialymstoku (1995) 46:60–68
pubmed: 11780581
Vong L, Ferraz JG, Panaccione R, Beck PL, Wallace JL (2010) A pro-resolution mediator, prostaglandin D2, is specifically up-regulated in individuals in long-term remission from ulcerative colitis. Proc Natl Acad Sci 107(26):12023–12027
pubmed: 20547854
pmcid: 2900663
doi: 10.1073/pnas.1004982107
Papp LV, Lu J, Holmgren A, Khanna KK (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 9(7):775–806
pubmed: 17508906
doi: 10.1089/ars.2007.1528
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83(5):803–812
pubmed: 8521497
doi: 10.1016/0092-8674(95)90193-0
Xue H, Wang W, Li Y, Shan Z, Li Y, Teng X, Gao Y, Fan C, Teng W (2010) Selenium upregulates CD4(+)CD25(+) regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2(h4) mice. Endocrine J 57(7):595–601. https://doi.org/10.1507/endocrj.k10e-063
doi: 10.1507/endocrj.k10e-063
Ala M, Kheyri Z (2021) The rationale for selenium supplementation in inflammatory bowel disease: a mechanism-based point of view. Nutrition 85:111153
pubmed: 33578241
doi: 10.1016/j.nut.2021.111153
Razi S, Baradaran Noveiry B, Keshavarz-Fathi M, Rezaei N (2019) IL-17 and colorectal cancer: from carcinogenesis to treatment. Cytokine 116:7–12. https://doi.org/10.1016/j.cyto.2018.12.021
doi: 10.1016/j.cyto.2018.12.021
pubmed: 30684916
Mohammadi M, Zahedi MJ, Nikpoor AR, Baneshi MR, Hayatbakhsh MM (2013) Interleukin-17 serum levels and TLR4 polymorphisms in ulcerative colitis. Iran J Immunol 10(2):83–92
pubmed: 23811547
Öhman L, Dahlén R, Isaksson S, Sjöling Å, Wick M-J, Sjövall H, Van Oudenhove L, Simrén M, Strid H (2013) Serum IL-17A in newly diagnosed treatment-naive patients with ulcerative colitis reflects clinical disease severity and predicts the course of disease. Inflamm Bowel Dis 19(11):2433–2439
pubmed: 23966065
doi: 10.1097/MIB.0b013e3182a563cb
Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK (2013) Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS ONE 8(7):e67845
pubmed: 23861820
pmcid: 3701622
doi: 10.1371/journal.pone.0067845
Karanikas G, Schuetz M, Kontur S, Duan H, Kommata S, Schoen R, Antoni A, Kletter K, Dudczak R, Willheim M (2008) No immunological benefit of selenium in consecutive patients with autoimmune thyroiditis. Thyroid 18(1):7–12
pubmed: 18302514
doi: 10.1089/thy.2007.0127
Mitsuyama K, Tomiyasu N, Takaki K, Masuda J, Yamasaki H, Kuwaki K, Takeda T, Kitazaki S, Tsuruta O, Sata M (2006) Interleukin-10 in the pathophysiology of inflammatory bowel disease: increased serum concentrations during the recovery phase. Mediators Inflam 2006:1
doi: 10.1155/MI/2006/26875
Geerling B, Badart-Smook A, Stockbrügger R, Brummer R-J (2000) Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr 54(6):514–521
pubmed: 10878655
doi: 10.1038/sj.ejcn.1601049
Castro Aguilar-Tablada T, Navarro-Alarcón M, Quesada Granados J, Samaniego Sánchez C, Rufián-Henares JÁ, Nogueras-Lopez F (2016) Ulcerative colitis and Crohn’s disease are associated with decreased serum selenium concentrations and increased cardiovascular risk. Nutrients 8(12):780–788
pubmed: 27916926
pmcid: 5188435
doi: 10.3390/nu8120780
Weisshof R, Chermesh I (2015) Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care 18(6):576–581
pubmed: 26418823
doi: 10.1097/MCO.0000000000000226
Cao Q, Huang Y-H, Jiang M, Dai C (2019) The prevalence and risk factors of psychological disorders, malnutrition and quality of life in IBD patients. Scand J Gastroenterol 54(12):1458–1466
pubmed: 31791216
doi: 10.1080/00365521.2019.1697897
Scaldaferri F, Pizzoferrato M, Lopetuso LR, Musca T, Ingravalle F, Sicignano LL, Mentella M, Miggiano G, Mele MC, Gaetani E (2017) Nutrition and IBD: malnutrition and/or sarcopenia? A practical guide. Gastroenterol Res Practice 2017
Kuroki F, Matsumoto T, Iida M (2003) Selenium is depleted in Crohn’s disease on enteral nutrition. Dig Dis 21(3):266–270
pubmed: 14571102
doi: 10.1159/000073346
Han YM, Yoon H, Lim S, Sung M-K, Shin CM, Park YS, Kim N, Lee DH, Kim JS (2017) Risk factors for vitamin D, zinc, and selenium deficiencies in Korean patients with inflammatory bowel disease. Gut and liver 11(3):363
pubmed: 28208007
pmcid: 5417778
doi: 10.5009/gnl16333
Elkjaer M, Shuhaibar M, Burisch J, Bailey Y, Scherfig H, Laugesen B, Avnstrøm S, Langholz E, O’Morain C, Lynge E (2010) E-health empowers patients with ulcerative colitis: a randomised controlled trial of the web-guided ‘Constant-care’approach. Gut 59(12):1652–1661
pubmed: 21071584
doi: 10.1136/gut.2010.220160