Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions.
Cancer therapy
Challenges
Development directions
NAE
NEDDylation
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
31 07 2023
31 07 2023
Historique:
received:
06
06
2023
accepted:
20
07
2023
medline:
2
8
2023
pubmed:
1
8
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
NEDDylation, a post-translational modification through three-step enzymatic cascades, plays crucial roles in the regulation of diverse biological processes. NEDD8-activating enzyme (NAE) as the only activation enzyme in the NEDDylation modification has become an attractive target to develop anticancer drugs. To date, numerous inhibitors or agonists targeting NAE have been developed. Among them, covalent NAE inhibitors such as MLN4924 and TAS4464 currently entered into clinical trials for cancer therapy, particularly for hematological tumors. This review explains the relationships between NEDDylation and cancers, structural characteristics of NAE and multistep mechanisms of NEDD8 activation by NAE. In addition, the potential approaches to discover NAE inhibitors and detailed pharmacological mechanisms of NAE inhibitors in the clinical stage are explored in depth. Importantly, we reasonably investigate the challenges of NAE inhibitors for cancer therapy and possible development directions of NAE-targeting drugs in the future.
Identifiants
pubmed: 37525282
doi: 10.1186/s13045-023-01485-7
pii: 10.1186/s13045-023-01485-7
pmc: PMC10388525
doi:
Substances chimiques
Ubiquitins
0
Antineoplastic Agents
0
NEDD8 protein, human
0
NEDD8 Protein
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
87Informations de copyright
© 2023. The Author(s).
Références
Cell Death Differ. 2015 Dec;22(12):2133-42
pubmed: 26045051
Sci Rep. 2017 Apr 13;7(1):880
pubmed: 28408736
Biochimie. 2012 Nov;94(11):2457-60
pubmed: 22709868
Cell Mol Life Sci. 2017 Dec;74(24):4387-4403
pubmed: 28646366
Bioorg Chem. 2021 Feb;107:104634
pubmed: 33476867
EMBO Rep. 2008 Mar;9(3):280-6
pubmed: 18274552
EBioMedicine. 2019 Jul;45:81-91
pubmed: 31208947
Exp Cell Res. 2020 Jul 15;392(2):112038
pubmed: 32360865
EBioMedicine. 2016 Dec;14:15-23
pubmed: 28029600
Cell Rep. 2021 Aug 24;36(8):109568
pubmed: 34433038
J Biol Chem. 1997 Nov 7;272(45):28557-62
pubmed: 9353319
Cell Commun Signal. 2019 Mar 18;17(1):25
pubmed: 30885218
Biochem Biophys Res Commun. 2016 Nov 18;480(3):380-386
pubmed: 27771247
J Exp Clin Cancer Res. 2022 Feb 23;41(1):75
pubmed: 35197103
Korean J Physiol Pharmacol. 2018 Nov;22(6):617-625
pubmed: 30402022
Insect Biochem Mol Biol. 2017 Nov;90:101-112
pubmed: 28964913
Biomedicines. 2017 Jun 21;5(2):
pubmed: 28635679
J Biol Chem. 2007 Jun 8;282(23):17032-40
pubmed: 17439941
Nature. 2013 Sep 19;501(7467):346-54
pubmed: 24048067
Biochem Biophys Res Commun. 2019 Jan 15;508(3):986-990
pubmed: 30545630
Semin Cancer Biol. 2003 Apr;13(2):159-67
pubmed: 12654259
J Exp Clin Cancer Res. 2022 Mar 30;41(1):115
pubmed: 35354476
J Chem Inf Model. 2018 Feb 26;58(2):422-429
pubmed: 29345925
Nat Struct Mol Biol. 2008 Mar;15(3):280-7
pubmed: 18264111
Biomed Res Int. 2014;2014:974309
pubmed: 25093192
Nat Rev Mol Cell Biol. 2015 Jan;16(1):30-44
pubmed: 25531226
Mol Carcinog. 2020 Feb;59(2):193-201
pubmed: 31782573
Cell Transplant. 2022 Jan-Dec;31:9636897221077921
pubmed: 35176901
Trends Cell Biol. 2018 Jun;28(6):436-453
pubmed: 29477613
Eur J Med Chem. 2018 Jun 25;154:294-304
pubmed: 29843100
Cell Discov. 2020 Feb 11;6:6
pubmed: 32047650
Clin Cancer Res. 2018 Aug 1;24(15):3741-3754
pubmed: 29233905
J Biol Chem. 2001 Dec 7;276(49):46655-60
pubmed: 11585840
Invest New Drugs. 2022 Oct;40(5):1042-1050
pubmed: 35932388
Nat Commun. 2021 Oct 12;12(1):5939
pubmed: 34642328
Eur J Cancer. 2019 May;112:12-19
pubmed: 30889492
Nat Commun. 2023 Jun 23;14(1):3762
pubmed: 37353483
Protein Cell. 2019 Oct;10(10):726-744
pubmed: 30850948
Cancer Cell. 2016 Aug 8;30(2):359-360
pubmed: 27505678
Nat Cell Biol. 2005 Oct;7(10):1014-20
pubmed: 16127432
J Biol Chem. 2019 Nov 15;294(46):17262-17277
pubmed: 31533986
Antioxid Redox Signal. 2014 Dec 10;21(17):2383-400
pubmed: 24410571
Nat Med. 2013 Nov;19(11):1423-37
pubmed: 24202395
Front Immunol. 2021 Aug 17;12:695331
pubmed: 34489942
J Biol Chem. 2012 Oct 12;287(42):35756-35767
pubmed: 22927439
Technol Cancer Res Treat. 2016 Aug;15(4):527-34
pubmed: 26082455
Oncogene. 2021 Feb;40(7):1217-1230
pubmed: 33420360
Chem Commun (Camb). 2011 Mar 7;47(9):2511-3
pubmed: 21240405
Cell Death Dis. 2017 Jun 1;8(6):e2834
pubmed: 28569775
Nature. 2016 May 5;533(7601):43-4
pubmed: 27096359
Mol Cell. 2010 Jan 15;37(1):102-11
pubmed: 20129059
Cell Cycle. 2018;17(2):191-199
pubmed: 29157102
Cancer Discov. 2021 Apr;11(4):933-959
pubmed: 33811125
Nat Commun. 2016 Jul 06;7:12125
pubmed: 27381497
Sci Rep. 2017 Jul 17;7(1):5599
pubmed: 28717191
Sci STKE. 2006 Nov 21;2006(362):.pe50
pubmed: 17119158
Cell Death Discov. 2023 Jan 23;9(1):23
pubmed: 36690633
Cancer Cell. 2011 Feb 15;19(2):168-76
pubmed: 21316600
Biosci Rep. 2022 Aug 31;42(8):
pubmed: 35880551
J Med Chem. 2018 Aug 23;61(16):7245-7260
pubmed: 30045621
Biochem Biophys Res Commun. 2019 Jan 22;508(4):1240-1244
pubmed: 30563767
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20
pubmed: 16861300
FEBS J. 2019 Feb;286(4):653-677
pubmed: 30659753
Cell Signal. 2018 Apr;44:92-102
pubmed: 29331584
ACS Med Chem Lett. 2011 May 16;2(8):577-82
pubmed: 24900352
Blood. 2016 May 5;127(18):2168-70
pubmed: 27151736
Nat Chem Biol. 2021 Oct;17(10):1075-1083
pubmed: 34518685
Signal Transduct Target Ther. 2020 Jul 10;5(1):123
pubmed: 32651357
Front Cell Neurosci. 2020 May 19;14:129
pubmed: 32508595
Nat Rev Mol Cell Biol. 2023 Feb;24(2):84
pubmed: 36536115
Cancer Biol Ther. 2015;16(3):420-9
pubmed: 25782162
Oncotarget. 2016 Jun 14;7(24):35643-35654
pubmed: 27224922
Mol Med Rep. 2017 Dec;16(6):9671-9677
pubmed: 29039560
Chem Sci. 2015 Sep 1;6(9):5235-5245
pubmed: 28717502
Cell Prolif. 2019 Mar;52(2):e12536
pubmed: 30341788
Acta Pharm Sin B. 2021 Nov;11(11):3567-3584
pubmed: 34900537
Structure. 2019 Aug 6;27(8):1316-1325.e6
pubmed: 31204252
Cells. 2019 Aug 16;8(8):
pubmed: 31426451
J Hematol Oncol. 2022 May 11;15(1):56
pubmed: 35545778
Oncotarget. 2015 Apr 20;6(11):9002-17
pubmed: 25797246
J Med Chem. 2020 Sep 10;63(17):8977-9002
pubmed: 32320239
Nature. 2003 Mar 20;422(6929):330-4
pubmed: 12646924
Nat Rev Cancer. 2017 Dec;17(12):708
pubmed: 29123247
Vet Comp Oncol. 2020 Sep;18(3):269-280
pubmed: 31665821
Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:375-398
pubmed: 28061686
J Biol Chem. 2015 Aug 21;290(34):20995-21006
pubmed: 26149689
Biochem Biophys Res Commun. 2017 Sep 16;491(2):463-468
pubmed: 28716733
Autophagy. 2012 Dec;8(12):1856-8
pubmed: 22965024
Br J Haematol. 2015 May;169(4):534-43
pubmed: 25733005
Cell Death Dis. 2015 Aug 27;6:e1867
pubmed: 26313918
Clin Cancer Res. 2015 Jan 15;21(2):439-47
pubmed: 25388161
Nature. 2009 Apr 9;458(7239):732-6
pubmed: 19360080
J Biol Chem. 2017 Jul 21;292(29):12089-12099
pubmed: 28572513
Int J Mol Sci. 2023 Apr 27;24(9):
pubmed: 37175636
Front Cell Dev Biol. 2021 Apr 30;9:667435
pubmed: 33996822
Cancer Lett. 2015 Jul 28;363(2):127-36
pubmed: 25615422
Mol Cancer. 2019 Apr 3;18(1):77
pubmed: 30943988
Mol Cancer Ther. 2012 Apr;11(4):942-51
pubmed: 22246439
Sci Rep. 2015 Nov 23;5:16948
pubmed: 26592553
Clin Cancer Res. 2014 Mar 15;20(6):1576-89
pubmed: 24634471
J Med Chem. 2021 May 13;64(9):6161-6178
pubmed: 33857374
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2935-44
pubmed: 27162365
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):
pubmed: 35101976
Nat Chem Biol. 2022 Feb;18(2):207-215
pubmed: 34949839
Cell. 2014 Jun 19;157(7):1671-84
pubmed: 24949976
J Mol Biol. 2006 Oct 20;363(2):395-404
pubmed: 16979187
Biochimie. 2014 Jul;102:211-5
pubmed: 24657219
Haematologica. 2022 Apr 01;107(4):825-835
pubmed: 33853293
Eur J Med Chem. 2020 Jan 1;185:111848
pubmed: 31732254
Eur J Med Chem. 2022 Mar 5;231:114156
pubmed: 35131538
Cancer Res. 2012 Jan 1;72(1):282-93
pubmed: 22072567
Cancer Res. 2010 Dec 15;70(24):10310-20
pubmed: 21159650
Oncotarget. 2016 Oct 4;7(40):66087-66099
pubmed: 27602774
Curr Oncol Rep. 2009 May;11(3):244-9
pubmed: 19336017
Nat Commun. 2017 Oct 27;8(1):1150
pubmed: 29074978
Cancer Cell Int. 2021 Jul 12;21(1):369
pubmed: 34247597
Oncotarget. 2015 Dec 8;6(39):41809-24
pubmed: 26497688
Leukemia. 2015 Oct;29(10):1981-92
pubmed: 25971362
Cancer Sci. 2019 Dec;110(12):3802-3810
pubmed: 31583781
Cell Death Dis. 2020 May 26;11(5):400
pubmed: 32457294
Cancer Chemother Pharmacol. 2018 May;81(5):797-808
pubmed: 29450620
Eur J Med Chem. 2021 Dec 5;225:113801
pubmed: 34455358
Cell Death Dis. 2014 Feb 13;5:e1059
pubmed: 24525735
Nat Commun. 2018 Dec 4;9(1):5145
pubmed: 30514846
Cell Death Discov. 2020 Jan 20;6:2
pubmed: 32123578
Cell Biol Toxicol. 2020 Aug;36(4):349-364
pubmed: 31907687
J Med Chem. 2017 Jan 12;60(1):497-503
pubmed: 27976900
Blood. 2013 Sep 19;122(12):2062-73
pubmed: 23863900
Clin Cancer Res. 2019 Feb 1;25(3):912-920
pubmed: 30274981
Autophagy. 2012 Nov;8(11):1677-9
pubmed: 22874562
Biochemistry. 2008 Aug 26;47(34):8961-9
pubmed: 18652489
J Biol Chem. 2003 Aug 1;278(31):28882-91
pubmed: 12759363
J Hepatol. 2022 Jul;77(1):177-190
pubmed: 35217064
Blood. 2010 Sep 2;116(9):1515-23
pubmed: 20525923
Int J Mol Sci. 2018 Dec 24;20(1):
pubmed: 30586948
Pharmacol Rev. 2021 Jan;73(1):1-58
pubmed: 33177128
Mol Omics. 2018 Dec 3;14(6):450-457
pubmed: 30255909
Nat Rev Cancer. 2017 Sep;17(9):528-542
pubmed: 28751651
Oncotarget. 2016 Jun 21;7(25):38380-38391
pubmed: 27224919
ACS Cent Sci. 2022 Feb 23;8(2):275-281
pubmed: 35237717
J Am Chem Soc. 2016 Oct 12;138(40):13123-13126
pubmed: 27626304
PLoS One. 2012;7(3):e34079
pubmed: 22457814
Mol Cancer Ther. 2017 Aug;16(8):1693-1704
pubmed: 28468780
Front Cell Dev Biol. 2021 Jun 07;9:681186
pubmed: 34164400
PLoS One. 2014 Apr 01;9(4):e93530
pubmed: 24691136
Proteins. 2009 Jun;75(4):895-910
pubmed: 19089947
Open Biol. 2015 Apr;5(4):150018
pubmed: 25833379
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):624-9
pubmed: 23267066
Cell Death Differ. 2018 Feb;25(2):319-329
pubmed: 29027989
Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188777
pubmed: 35963551
Cell. 2017 Aug 24;170(5):1044-1044.e1
pubmed: 28841411
J Am Chem Soc. 2013 Nov 13;135(45):16948-62
pubmed: 24138456
Cancer Res. 2011 Apr 1;71(7):2750-60
pubmed: 21317224
Sci Rep. 2016 Apr 11;6:24218
pubmed: 27063292
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30668548
Curr Biol. 2020 Aug 17;30(16):R921-R925
pubmed: 32810447
Neoplasia. 2022 Oct;32:100823
pubmed: 35907292
Biomed Pharmacother. 2020 Oct;130:110654
pubmed: 34321162
Cell Cycle. 2019 Sep;18(18):2307-2322
pubmed: 31349760
Oncotarget. 2016 Jul 19;7(29):45263-45274
pubmed: 27223074
Blood. 2016 May 5;127(18):2219-30
pubmed: 26851293
J Med Chem. 2018 Apr 12;61(7):2680-2693
pubmed: 29547696
Eur J Med Chem. 2018 Jan 1;143:1021-1027
pubmed: 29232579
J Immunother Cancer. 2020 Oct;8(2):
pubmed: 33037117
Eur J Med Chem. 2020 Apr 15;192:112153
pubmed: 32135407
Nature. 2019 Jun;570(7761):E34-E42
pubmed: 31217603
Dig Dis Sci. 2023 Apr;68(4):1351-1363
pubmed: 36098876
Redox Biol. 2016 Aug;8:341-7
pubmed: 26966893
Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1070-L1080
pubmed: 30892082
Clin Cancer Res. 2017 Feb 15;23(4):1104-1116
pubmed: 27591266
Neoplasia. 2011 Jun;13(6):561-9
pubmed: 21677879
Oncogene. 2013 Mar 14;32(11):1441-51
pubmed: 22641220
Acta Pharm Sin B. 2020 May;10(5):746-765
pubmed: 32528826
Cancer Res. 2011 Apr 15;71(8):3042-51
pubmed: 21487042
Oncotarget. 2014 Sep 15;5(17):7820-32
pubmed: 25229838
Science. 2002 Feb 15;295(5558):1294-8
pubmed: 11847342
Mol Cancer Ther. 2019 Jul;18(7):1205-1216
pubmed: 31092565
PLoS Pathog. 2018 Nov 21;14(11):e1007440
pubmed: 30462731
Science. 2012 Nov 23;338(6110):1069-72
pubmed: 23086999
Chem Sci. 2020 Dec 14;12(4):1535-1543
pubmed: 34163916
Redox Biol. 2021 Oct;46:102114
pubmed: 34454165
Cancer Res. 2013 Jan 1;73(1):225-34
pubmed: 23100467
Trends Cell Biol. 2018 Nov;28(11):926-940
pubmed: 30107971
Mol Cell Oncol. 2019 May 22;6(5):e1618174
pubmed: 31528694
Front Oncol. 2023 Feb 22;13:1084523
pubmed: 36910623
Mol Cancer Ther. 2011 Dec;10(12):2415-25
pubmed: 21914854
Mol Cell. 2018 Jun 21;70(6):1008-1024.e6
pubmed: 29932898
Mol Cell. 2007 Jul 20;27(2):228-237
pubmed: 17643372
Curr Opin Plant Biol. 2018 Oct;45(Pt A):112-119
pubmed: 29909289
Nature. 2020 Feb;578(7795):461-466
pubmed: 32051583
Cell Biosci. 2021 Mar 17;11(1):55
pubmed: 33731189
Eur J Cancer. 2021 Nov;157:474-484
pubmed: 34649118
Chem Commun (Camb). 2022 Mar 10;58(21):3541-3544
pubmed: 35195624
Cell Death Dis. 2012 Sep 06;3:e386
pubmed: 22951983
J Am Chem Soc. 2019 Oct 2;141(39):15700-15709
pubmed: 31497954
J Hematol Oncol. 2021 Apr 7;14(1):57
pubmed: 33827629
Biotechnol Appl Biochem. 2022 Feb;69(1):330-341
pubmed: 33469954
Nat Cell Biol. 2017 Aug 31;19(9):1008-1009
pubmed: 28855731
Cell Death Dis. 2022 Oct 3;13(10):844
pubmed: 36192389
FEBS J. 2021 Jul;288(13):3884-3912
pubmed: 33025631
Mol Cell. 2005 Feb 4;17(3):341-50
pubmed: 15694336
Transl Oncol. 2012 Oct;5(5):305-12
pubmed: 23066438
Chem Rev. 2018 Feb 14;118(3):889-918
pubmed: 28234446
Int Immunopharmacol. 2022 Dec;113(Pt A):109329
pubmed: 36252470
Phytother Res. 2019 Jun;33(6):1658-1669
pubmed: 30945389
Invest New Drugs. 2019 Feb;37(1):87-97
pubmed: 29781056
Eur J Med Chem. 2017 Jun 16;133:174-183
pubmed: 28388520
Chembiochem. 2013 Jul 22;14(11):1323-30
pubmed: 23824602
Invest New Drugs. 2021 Aug;39(4):1036-1046
pubmed: 33560503
Neoplasia. 2012 May;14(5):360-7
pubmed: 22745582
Cell Death Dis. 2019 Aug 13;10(8):611
pubmed: 31406107
Cancer Lett. 2017 Feb 28;387:61-68
pubmed: 26845449
Curr Biol. 2019 Jul 22;29(14):R671-R677
pubmed: 31336079
Mol Cell Biol. 2000 Apr;20(7):2326-33
pubmed: 10713156
Curr Biol. 2022 May 23;32(10):R448-R452
pubmed: 35609537
Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188446
pubmed: 33058997
Mol Metab. 2021 Nov;53:101275
pubmed: 34153521
Hepatology. 2017 Feb;65(2):694-709
pubmed: 28035772
Anal Biochem. 2013 Aug 15;439(2):109-15
pubmed: 23624319
Clin Pharmacol Drug Dev. 2023 Mar;12(3):257-266
pubmed: 36382849
Cell Rep. 2019 Apr 30;27(5):1356-1363.e3
pubmed: 31042464
Cell Cycle. 2022 Jan;21(2):152-171
pubmed: 34874801
PLoS One. 2012;7(11):e49574
pubmed: 23185368
Biochem Biophys Res Commun. 2017 Jun 17;488(1):1-5
pubmed: 28450112
Vet Comp Oncol. 2018 Dec;16(4):606-615
pubmed: 30101447
J Biol Chem. 2011 Nov 25;286(47):40867-77
pubmed: 21969368
Behav Brain Res. 2021 Feb 5;399:113051
pubmed: 33279641
Annu Rev Cancer Biol. 2017 Mar;1:19-39
pubmed: 31119201
ACS Chem Biol. 2016 Jul 15;11(7):1901-7
pubmed: 27135934
Mol Cell. 2003 Dec;12(6):1427-37
pubmed: 14690597
Mol Cancer Ther. 2018 Feb;17(2):368-380
pubmed: 28838998
Nature. 2007 Jan 25;445(7126):394-8
pubmed: 17220875
Angiogenesis. 2022 Nov;25(4):435-437
pubmed: 35881257
Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2473-2483
pubmed: 31941714
Nat Rev Cancer. 2011 Apr;11(4):239-53
pubmed: 21430696
Nat Struct Mol Biol. 2004 Oct;11(10):927-35
pubmed: 15361859
Oncogenesis. 2017 Sep 11;6(9):e377
pubmed: 28892104
Med Res Rev. 2019 Jul;39(4):1398-1426
pubmed: 30746734
J Chem Inf Model. 2014 Jun 23;54(6):1785-97
pubmed: 24857708
Leukemia. 2016 May;30(5):1190-4
pubmed: 26369982