Vanishing Adrenal Glands: Bilateral Adrenal Hemorrhage With Adrenal Insufficiency in COVID-19 Infection.
adrenal hemorrhage
adrenal insufficiency
antiphospholipid syndrome
coronavirus disease 2019
covid-19 infection
mineralocorticoid
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
accepted:
30
06
2023
medline:
1
8
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19) has been associated with thrombotic and endocrine complications, including adrenal insufficiency in the setting of adrenal hemorrhage. We present a patient diagnosed with antiphospholipid syndrome (APLS) in the setting of COVID-19 infection resulting in bilateral adrenal hemorrhage, subsequently leading to adrenal insufficiency. Acute adrenal hemorrhage is an underrecognized cause of decompensation, multisystem failure, and death in severe illness. Reports of adrenal insufficiency in the setting of COVID-19 infection revealed microscopic infarction, which can increase the risk of hemorrhage. Other mechanisms include severe hyperinflammatory response and cytokine storm leading to endothelial dysfunction, vascular injury, adrenal parenchymal damage, and hemorrhage. COVID-19 infection can be associated with coagulopathy and thromboembolic events and can lead to adrenal hemorrhage. Adrenal insufficiency is life-threatening and needs to be recognized promptly. There can be a latent phase between hemorrhagic events and adrenal failure; hence, close monitoring and timely intervention are important.
Identifiants
pubmed: 37525808
doi: 10.7759/cureus.41210
pmc: PMC10387330
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e41210Informations de copyright
Copyright © 2023, Majety et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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