Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein-protein interaction network analyses.
Pregnancy
Child
Female
Humans
Zika Virus Infection
/ genetics
Zika Virus
/ physiology
Axl Receptor Tyrosine Kinase
Toll-Like Receptor 3
/ genetics
Receptor Protein-Tyrosine Kinases
/ genetics
Proto-Oncogene Proteins
/ genetics
Protein Interaction Maps
/ genetics
Teratogenesis
ErbB Receptors
/ metabolism
STAT2 Transcription Factor
/ genetics
AXL receptor tyrosine kinase
STAT2 transcription factor
Zika virus infection
congenital abnormalities
disease susceptibility
maternal exposure
toll-like receptor 3
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
revised:
02
07
2023
received:
13
02
2023
accepted:
11
07
2023
medline:
3
10
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Zika virus (ZIKV) is a human teratogen that causes congenital Zika syndrome (CZS). AXL, TLR3, and STAT2 are proteins involved in the ZIKV's entry into cells (AXL) and host's immune response (TLR3 and STAT2). In this study, we evaluated the role of genetic polymorphisms in these three genes as risk factors to CZS, and highlighted which proteins that interact with them could be important for ZIKV infection and teratogenesis. We evaluate eighty-eight children exposed to ZIKV during the pregnancy, 40 with CZS and 48 without congenital anomalies. The evaluated polymorphisms in AXL (rs1051008), TLR3 (rs3775291), and STAT2 (rs2066811) were genotyped using TaqMan® Genotyping Assays. A protein-protein interaction network was created in STRING database and analyzed in Cytoscape software. We did not find any statistical significant association among the polymorphisms and the occurrence of CZS. Through the analyses of the network composed by AXL, TLR3, STAT2 and their interactions targets, we found that EGFR and SRC could be important proteins for the ZIKV infection and its teratogenesis. In summary, our results demonstrated that the evaluated polymorphisms do not seem to represent risk factors for CZS; however, EGFR and SRC appear to be important proteins that should be investigated in future studies.
Substances chimiques
Axl Receptor Tyrosine Kinase
0
Toll-Like Receptor 3
0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Proto-Oncogene Proteins
0
ErbB Receptors
EC 2.7.10.1
TLR3 protein, human
0
STAT2 protein, human
0
STAT2 Transcription Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1500-1512Informations de copyright
© 2023 Wiley Periodicals LLC.
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