Oxidative metabolism of neutrophils in acute coronary syndrome.
acute coronary syndrome
neutrophils
reactive oxygen species
Journal
Cardiovascular journal of Africa
ISSN: 1680-0745
Titre abrégé: Cardiovasc J Afr
Pays: South Africa
ID NLM: 101313864
Informations de publication
Date de publication:
25 Jul 2023
25 Jul 2023
Historique:
received:
29
06
2022
accepted:
05
06
2023
medline:
1
8
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
aheadofprint
Résumé
Inflammation in acute coronary syndrome (ACS) involves neutrophil activation and oxidative stress. Here, we studied the production of reactive oxygen species (ROS) by neutrophils in ACS. The study included 42 patients, men and women aged 46-91 years with ischaemic heart disease (IHD), non-ST-segment elevation ACS and ST-segment elevation ACS. Neutrophil-derived ROS were quantified with double-step stimulated luminol-enhanced chemiluminometry. The specific indices of spontaneous and double-step stimulated chemiluminescence did not differ in the subgroups of IHD, non-ST-segment elevation ACS and ST-segment elevation ACS. The total double-step stimulated ROS production by neutrophils was significantly higher in ST-segment elevation ACS than in non-ST-segment elevation ACS and IHD. In ACS, special activation mechanisms of peripherical neutrophils were not triggered in our study. The significant increase in free radical production by neutrophils in acute myocardial infarction was presumably a consequence of an increase in their number.
Sections du résumé
BACKGROUND
BACKGROUND
Inflammation in acute coronary syndrome (ACS) involves neutrophil activation and oxidative stress. Here, we studied the production of reactive oxygen species (ROS) by neutrophils in ACS.
METHODS
METHODS
The study included 42 patients, men and women aged 46-91 years with ischaemic heart disease (IHD), non-ST-segment elevation ACS and ST-segment elevation ACS. Neutrophil-derived ROS were quantified with double-step stimulated luminol-enhanced chemiluminometry.
RESULTS
RESULTS
The specific indices of spontaneous and double-step stimulated chemiluminescence did not differ in the subgroups of IHD, non-ST-segment elevation ACS and ST-segment elevation ACS. The total double-step stimulated ROS production by neutrophils was significantly higher in ST-segment elevation ACS than in non-ST-segment elevation ACS and IHD.
CONCLUSIONS
CONCLUSIONS
In ACS, special activation mechanisms of peripherical neutrophils were not triggered in our study. The significant increase in free radical production by neutrophils in acute myocardial infarction was presumably a consequence of an increase in their number.
Identifiants
pubmed: 37526958
doi: 10.5830/CVJA-2023-032
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM