Changes in patterns of age-related network connectivity are associated with risk for schizophrenia.
familial risk
functional network connectivity
neurodevelopment
polygenic risk
schizophrenia
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 08 2023
08 08 2023
Historique:
pmc-release:
01
02
2024
medline:
3
8
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Alterations in fMRI-based brain functional network connectivity (FNC) are associated with schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding the onset of SCZ, which often occurs in early adulthood. Thus, age-sensitive FNC changes may be relevant to SCZ risk-related FNC. We used independent component analysis to estimate FNC from childhood to adulthood in 9,236 individuals. To capture individual brain features more accurately than single-session fMRI, we studied an average of three fMRI scans per individual. To identify potential familial risk-related FNC changes, we compared age-related FNC in first-degree relatives of SCZ patients mostly including unaffected siblings (SIB) with neurotypical controls (NC) at the same age stage. Then, we examined how polygenic risk scores for SCZ influenced risk-related FNC patterns. Finally, we investigated the same risk-related FNC patterns in adult SCZ patients (oSCZ) and young individuals with subclinical psychotic symptoms (PSY). Age-sensitive risk-related FNC patterns emerge during adolescence and early adulthood, but not before. Young SIB always followed older NC patterns, with decreased FNC in a cerebellar-occipitoparietal circuit and increased FNC in two prefrontal-sensorimotor circuits when compared to young NC. Two of these FNC alterations were also found in oSCZ, with one exhibiting reversed pattern. All were linked to polygenic risk for SCZ in unrelated individuals (R
Identifiants
pubmed: 37527347
doi: 10.1073/pnas.2221533120
pmc: PMC10410767
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2221533120Subventions
Organisme : HHS | NIH | National Institute of Mental Health (NIMH)
ID : R01MH118695
Références
Evid Based Ment Health. 2019 Nov;22(4):153-160
pubmed: 31563865
JAMA Psychiatry. 2022 Aug 1;79(8):780-789
pubmed: 35675082
iScience. 2020 Jan 24;23(1):100801
pubmed: 31958758
Schizophr Bull. 1994;20(3):453-80
pubmed: 7526447
Eur J Neurosci. 2012 Dec;36(11):3559-67
pubmed: 22909094
Neuroimage. 2019 Apr 1;189:432-444
pubmed: 30659958
Schizophr Bull. 2018 Jun 6;44(4):844-853
pubmed: 29040762
Dev Cogn Neurosci. 2021 Dec;52:101031
pubmed: 34742018
Nat Commun. 2022 Aug 22;13(1):4929
pubmed: 35995794
Nat Neurosci. 2017 Apr;20(4):513-515
pubmed: 28218917
Schizophr Res. 2010 Oct;123(1):45-52
pubmed: 20688479
Eur Psychiatry. 2015 Jul;30(5):633-40
pubmed: 25841662
Schizophr Bull. 2014 Jul;40(4):729-36
pubmed: 24860087
Trends Cogn Sci. 2021 Sep;25(9):776-787
pubmed: 34134933
NPJ Sci Learn. 2018 Jan 10;3:1
pubmed: 30631462
Neuroimage. 2002 Nov;17(3):1394-402
pubmed: 12414279
Arch Gen Psychiatry. 1987 Jul;44(7):660-9
pubmed: 3606332
Neuroreport. 1997 Sep 8;8(13):2977-84
pubmed: 9376542
Neurobiol Aging. 2010 May;31(5):839-52
pubmed: 18674847
Schizophr Bull. 2022 Sep 1;48(5):967-980
pubmed: 35674151
J Neurosci. 2016 Nov 30;36(48):12083-12094
pubmed: 27903719
Cereb Cortex. 2014 Mar;24(3):728-36
pubmed: 23146968
Netw Neurosci. 2018 Jun 01;2(2):175-199
pubmed: 30215032
Nat Rev Neurosci. 2006 Oct;7(10):818-27
pubmed: 16988657
Neuroscience. 2020 Oct 15;446:14-27
pubmed: 32858143
Neurosci Lett. 2019 Jan 1;688:62-75
pubmed: 29997061
Cereb Cortex. 2000 Nov;10(11):1078-92
pubmed: 11053229
Neuroimage Clin. 2015 Aug 06;9:233-43
pubmed: 26484048
Psychophysiology. 2012 Mar;49(3):283-304
pubmed: 22220910
Am J Psychiatry. 2000 Jan;157(1):26-33
pubmed: 10618009
Biol Psychiatry. 2023 Jul 15;94(2):121-130
pubmed: 36740470
Schizophr Bull. 2021 Apr 29;47(3):594-603
pubmed: 33693921
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
pubmed: 15148381
Nature. 2022 Apr;604(7906):502-508
pubmed: 35396580
Brain. 2008 Sep;131(Pt 9):2489-98
pubmed: 18669483
J Neurosci Res. 2021 Jan;99(1):236-262
pubmed: 32557768
Neuroimage Clin. 2020;28:102375
pubmed: 32961402
JAMA Psychiatry. 2015 Sep;72(9):900-8
pubmed: 26176706
JAMA Psychiatry. 2014 Mar;71(3):236-47
pubmed: 24382711
Psychol Med. 2013 Aug;43(8):1661-71
pubmed: 23111173
Cortex. 2017 Jun;91:234-249
pubmed: 28190516
Neuroimage. 2013 Apr 1;69:157-97
pubmed: 23194820
Proc Natl Acad Sci U S A. 1967 Jul;58(1):199-205
pubmed: 5231600
Neuropsychopharmacology. 2020 Mar;45(4):613-621
pubmed: 31581175
Neuroimage. 2002 Jul;16(3 Pt 1):651-62
pubmed: 12169250
Neuropsychology. 2002 Jul;16(3):370-9
pubmed: 12146684
Arch Gen Psychiatry. 2003 Dec;60(12):1187-92
pubmed: 14662550
Int J Neuropsychopharmacol. 2004 Mar;7 Suppl 1:S7-S13
pubmed: 14972079
Nat Rev Neurosci. 2008 Dec;9(12):947-57
pubmed: 19002191
JCPP Adv. 2023 Jan 20;3(1):e12137
pubmed: 37431321
JAMA Psychiatry. 2013 Jan;70(1):107-20
pubmed: 23165428
Neuroimage. 2014 Aug 15;97:117-26
pubmed: 24736181
Front Neurol. 2019 Aug 14;10:789
pubmed: 31474922
Front Neurosci. 2018 Mar 01;12:114
pubmed: 29545739
Brain. 2018 Apr 1;141(4):1218-1228
pubmed: 29415119
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110440
pubmed: 34536513
JAMA Psychiatry. 2018 Sep 1;75(9):960-968
pubmed: 29971330
Sci Adv. 2023 Apr 14;9(15):eade2812
pubmed: 37058565
Neuroscience. 2009 Nov 24;164(1):288-99
pubmed: 19393294
Neuron. 2014 Aug 6;83(3):518-32
pubmed: 25102558
Nat Rev Neurosci. 2001 Jul;2(7):484-91
pubmed: 11433373
Lancet. 2014 May 10;383(9929):1677-1687
pubmed: 24315522
J Neurosci. 2021 Mar 24;41(12):2684-2702
pubmed: 33542083
Neuroimage. 2013 Oct 15;80:169-89
pubmed: 23684877
Soc Cogn Affect Neurosci. 2013 Dec;8(8):855-62
pubmed: 22842906
World Psychiatry. 2019 Oct;18(3):366-367
pubmed: 31496088
Psychol Sci. 2020 Jul;31(7):792-806
pubmed: 32489141
Schizophr Bull. 2012 Jan;38(1):114-24
pubmed: 22124089
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Psychopathology. 2014;47(5):285-6
pubmed: 25059260
Nat Neurosci. 2015 Nov;18(11):1664-71
pubmed: 26457551
Biol Psychiatry. 2011 Jul 1;70(1):64-72
pubmed: 21514570
Neuroimage. 2019 Apr 1;189:516-532
pubmed: 30708106
Schizophr Bull. 2019 Jan 1;45(1):190-198
pubmed: 29272464
J Child Psychol Psychiatry. 2015 Dec;56(12):1356-1369
pubmed: 25858255
Biol Psychiatry. 2004 Aug 1;56(3):190-7
pubmed: 15271588
J Cogn Neurosci. 2016 Mar;28(3):446-59
pubmed: 26601909
Schizophr Res. 2018 Jul;197:550-556
pubmed: 29463457
Hum Brain Mapp. 2001 Nov;14(3):140-51
pubmed: 11559959
J Neurosci. 2015 Jan 7;35(1):267-86
pubmed: 25568120
J Neurosci. 2020 Feb 5;40(6):1265-1275
pubmed: 31896669
Nature. 2018 Oct;562(7726):210-216
pubmed: 30305740
Psychiatry Res. 2006 Oct 30;147(2-3):221-6
pubmed: 16952445
Eur Psychiatry. 2012 May;27(4):258-63
pubmed: 20934858
J Neurosci. 2018 Sep 26;38(39):8378-8387
pubmed: 30104335
Neuropsychiatr Dis Treat. 2013;9:449-61
pubmed: 23579318
Neuroimage. 2016 Jul 15;135:16-31
pubmed: 27114055
Neuron. 2014 Jul 2;83(1):238-51
pubmed: 24991964
JAMA Psychiatry. 2016 Jun 1;73(6):598-605
pubmed: 27145286
Neuropsychopharmacology. 2022 Jan;47(1):41-57
pubmed: 34645980
Brain Sci. 2022 Apr 20;12(5):
pubmed: 35624910
Neuroimage. 2013 Dec;83:550-8
pubmed: 23747458
J Neurosci. 2009 Nov 25;29(47):14812-9
pubmed: 19940176
Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2221533120
pubmed: 37527347
Front Hum Neurosci. 2010 Mar 09;3:62
pubmed: 20300465