Multiple Sclerosis Is Associated With Achalasia and Diffuse Esophageal Spasm.
Achalasia
Database analysis
Diffuse esophageal spasm
Esophageal dysphagia
Multiple sclerosis
Journal
Journal of neurogastroenterology and motility
ISSN: 2093-0879
Titre abrégé: J Neurogastroenterol Motil
Pays: Korea (South)
ID NLM: 101530189
Informations de publication
Date de publication:
30 Oct 2023
30 Oct 2023
Historique:
received:
10
10
2022
revised:
12
04
2023
accepted:
12
04
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is an inflammatory disease characterized by the demyelination of primarily the central nervous system. Diffuse esophageal spasm (DES) and achalasia are both disorders of esophageal peristalsis which cause clinical symptoms of dysphagia. Mechanisms involving dysfunction of the pre- and post-ganglionic nerve fibers of the myenteric plexus have been proposed. We sought to determine whether MS confers an increased risk of developing achalasia or DES. Cohort analysis was done using the Explorys database. Univariate logistic regression was performed to determine the odds MS confers to each motility disorder studied. Comparison of proportions of dysautonomia comorbidities was performed among the cohorts. Patients with a prior diagnosis of diabetes mellitus, chronic Chagas' disease, opioid use, or CREST syndrome were excluded from the study. Odds of MS patients developing achalasia or DES were (OR, 2.09; 95% CI, 1.73-2.52; Patients with MS have higher odds of developing achalasia or DES compared to patients without MS. MS patients with achalasia or DES have higher rates of dysautonomia comorbidities. This suggests that these patients have a more severe disease phenotype in regards to the extent of neuronal degradation and demyelination causing the autonomic dysfunction.
Sections du résumé
Background/Aims
UNASSIGNED
Multiple sclerosis (MS) is an inflammatory disease characterized by the demyelination of primarily the central nervous system. Diffuse esophageal spasm (DES) and achalasia are both disorders of esophageal peristalsis which cause clinical symptoms of dysphagia. Mechanisms involving dysfunction of the pre- and post-ganglionic nerve fibers of the myenteric plexus have been proposed. We sought to determine whether MS confers an increased risk of developing achalasia or DES.
Methods
UNASSIGNED
Cohort analysis was done using the Explorys database. Univariate logistic regression was performed to determine the odds MS confers to each motility disorder studied. Comparison of proportions of dysautonomia comorbidities was performed among the cohorts. Patients with a prior diagnosis of diabetes mellitus, chronic Chagas' disease, opioid use, or CREST syndrome were excluded from the study.
Results
UNASSIGNED
Odds of MS patients developing achalasia or DES were (OR, 2.09; 95% CI, 1.73-2.52;
Conclusions
UNASSIGNED
Patients with MS have higher odds of developing achalasia or DES compared to patients without MS. MS patients with achalasia or DES have higher rates of dysautonomia comorbidities. This suggests that these patients have a more severe disease phenotype in regards to the extent of neuronal degradation and demyelination causing the autonomic dysfunction.
Identifiants
pubmed: 37528077
pii: jnm22173
doi: 10.5056/jnm22173
pmc: PMC10577467
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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