Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
21
11
2022
accepted:
12
07
2023
medline:
23
10
2023
pubmed:
2
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Endocannabinoids (eCB) and cannabinoid receptor 1 (CB1) play important roles in mediating short- and long-term synaptic plasticity in many brain regions involved in learning and memory, as well as the reinforcing effects of misused substances. Ethanol-induced plasticity and neuroadaptations predominantly occur in striatal direct pathway projecting medium spiny neurons (dMSNs). It is hypothesized that alterations in eCB neuromodulation may be involved. Recent work has implicated a role of eCB 2-arachidonoylglycerol (2-AG) in the rewarding effects of ethanol. However, there is insufficient research to answer which cellular subtype is responsible for mediating the 2-AG eCB signal that might be involved in the rewarding properties of ethanol and the mechanisms by which that occurs. To examine the role of dMSN mediated 2-AG signaling in ethanol related synaptic transmission and behaviors, we used conditional knockout mice in which the 2-AG-synthesizing enzyme diacylglycerol lipase α (DGLα) was deleted in dMSNs, DGLα
Identifiants
pubmed: 37528221
doi: 10.1038/s41386-023-01671-8
pii: 10.1038/s41386-023-01671-8
pmc: PMC10584873
doi:
Substances chimiques
glyceryl 2-arachidonate
8D239QDW64
Glycerides
0
Endocannabinoids
0
Ethanol
3K9958V90M
Receptor, Cannabinoid, CB1
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1941-1951Subventions
Organisme : Intramural NIH HHS
ID : ZIA AA000416
Pays : United States
Organisme : NIAAA NIH HHS
ID : R00 AA027740
Pays : United States
Informations de copyright
© 2023. American College of Neuropsychopharmacology.
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