Terminally exhausted CD8
Aged immune response
Respiratory viral infection
Viral immunology
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
01 Aug 2023
01 Aug 2023
Historique:
received:
16
04
2023
accepted:
18
07
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
1
8
2023
Statut:
epublish
Résumé
Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositivity, antibodies fail to effectively protect the elderly. Therefore, we hypothesized that severe respiratory illness in the elderly is due to deficient CD8 Here, we establish an aged mouse model of human metapneumovirus infection (HMPV) wherein aged C57BL/6 mice exhibit worsened weight loss, clinical disease, lung pathology and delayed viral clearance compared to young adult mice. Aged mice generate fewer lung-infiltrating HMPV epitope-specific CD8 This study identifies terminal CD8
Sections du résumé
BACKGROUND
BACKGROUND
Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositivity, antibodies fail to effectively protect the elderly. Therefore, we hypothesized that severe respiratory illness in the elderly is due to deficient CD8
RESULTS
RESULTS
Here, we establish an aged mouse model of human metapneumovirus infection (HMPV) wherein aged C57BL/6 mice exhibit worsened weight loss, clinical disease, lung pathology and delayed viral clearance compared to young adult mice. Aged mice generate fewer lung-infiltrating HMPV epitope-specific CD8
CONCLUSIONS
CONCLUSIONS
This study identifies terminal CD8
Identifiants
pubmed: 37528458
doi: 10.1186/s12979-023-00365-5
pii: 10.1186/s12979-023-00365-5
pmc: PMC10391960
doi:
Types de publication
Journal Article
Langues
eng
Pagination
40Subventions
Organisme : NHLBI NIH HHS
ID : 1F30HL159915-01A1
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00005
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93022D00005
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085062
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93023D00005
Pays : United States
Organisme : NIH HHS
ID : K12 HD000850
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00005
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008208
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00005
Pays : United States
Organisme : NIH HHS
ID : T32 GM-008208
Pays : United States
Organisme : NHLBI NIH HHS
ID : F30 HL159915
Pays : United States
Informations de copyright
© 2023. The Author(s).
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