Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity, and emerges early during adult neurogenesis.

Munc13 double-knockout mice heterosynaptic plasticity intrinsic/extrinsic synaptic dynamics lognormal distribution multiplicative noise spike-timing-dependent plasticity (STDP)

Journal

Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419

Informations de publication

Date de publication:
08 2023
Historique:
medline: 3 8 2023
pubmed: 2 8 2023
entrez: 2 8 2023
Statut: ppublish

Résumé

Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity and plasticity on the spine size distribution in adult-born hippocampal granule cells from rats with induced homo- and heterosynaptic long-term plasticity

Identifiants

pubmed: 37528732
doi: 10.1098/rsob.230063
pmc: PMC10394416
doi:

Banques de données

figshare
['10.6084/m9.figshare.c.6742218']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

230063

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Auteurs

Nina Rößler (N)

Faculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.
Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.

Tassilo Jungenitz (T)

Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.

Albrecht Sigler (A)

Department of Molecular Neurobiology, Max Planck Institute of Multidisciplinary Sciences, Göttingen, 37077, Germany.

Alexander Bird (A)

Faculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.
Frankfurt Institute for Advanced Studies, Frankfurt am Main, 60438, Germany.
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, 60528, Germany.

Martin Mittag (M)

Faculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.
Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.

Jeong Seop Rhee (JS)

Department of Molecular Neurobiology, Max Planck Institute of Multidisciplinary Sciences, Göttingen, 37077, Germany.

Thomas Deller (T)

Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.

Hermann Cuntz (H)

Faculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.
Frankfurt Institute for Advanced Studies, Frankfurt am Main, 60438, Germany.
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, 60528, Germany.

Nils Brose (N)

Department of Molecular Neurobiology, Max Planck Institute of Multidisciplinary Sciences, Göttingen, 37077, Germany.

Stephan W Schwarzacher (SW)

Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.

Peter Jedlicka (P)

Faculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.
Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.

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Classifications MeSH