Deletion of the
atrial natriuretic peptide
lung inflammation
natriuretic peptide receptor C
obesity
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
06
01
2023
revised:
05
07
2023
accepted:
09
07
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
epublish
Résumé
Previous studies have shown that atrial natriuretic peptide (ANP) attenuates agonist-induced pulmonary edema and that this effect may be mediated in part by the ANP clearance receptor, natriuretic peptide receptor-C (NPR-C). Obesity has been associated with lower plasma ANP levels due to increased expression of NPR-C, and with decreased severity of acute lung injury (ALI). Therefore, we hypothesized that increased expression of NPR-C may attenuate ALI severity in obese populations. To test this, we examined ALI in
Identifiants
pubmed: 37528869
doi: 10.1002/pul2.12270
pii: PUL212270
pmc: PMC10387407
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12270Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103652
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123965
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134625
Pays : United States
Informations de copyright
© 2023 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
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