Mouth breathing, dry air, and low water permeation promote inflammation, and activate neural pathways, by osmotic stresses acting on airway lining mucus.
chronic cough
dehydration
hypertonic saline
mucus
respiratory droplets
Journal
QRB discovery
ISSN: 2633-2892
Titre abrégé: QRB Discov
Pays: England
ID NLM: 101772102
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
10
2022
revised:
01
02
2023
accepted:
06
02
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
epublish
Résumé
Respiratory disease and breathing abnormalities worsen with dehydration of the upper airways. We find that humidification of inhaled air occurs by evaporation of water over mucus lining the upper airways in such a way as to deliver an osmotic force on mucus, displacing it towards the epithelium. This displacement thins the periciliary layer of water beneath mucus while thickening topical water that is partially condensed from humid air on exhalation. With the rapid mouth breathing of dry air, this condensation layer, not previously reported while common to transpiring hydrogels in nature, can deliver an osmotic compressive force of up to around 100 cm H
Identifiants
pubmed: 37529032
doi: 10.1017/qrd.2023.1
pii: S2633289223000017
pmc: PMC10392678
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e3Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
D.A.E. is a cofounder and shareholder of Sensory Cloud Inc. and a cofounder (while not a shareholder) of Pulmatrix. Each of these companies advances science, technology, and products for consumer health or therapeutic use by the inhalation of aerosols.
Références
Langmuir. 2020 Nov 3;36(43):12773-12783
pubmed: 33094612
Annu Rev Physiol. 2015;77:379-406
pubmed: 25386990
Nat Rev Immunol. 2021 Jun;21(6):347-362
pubmed: 33442032
Immunology. 1992 Nov;77(3):330-7
pubmed: 1478679
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):
pubmed: 27864314
Pulm Pharmacol Ther. 2019 Apr;55:67-74
pubmed: 30771475
Lancet Respir Med. 2020 Aug;8(8):775-785
pubmed: 32109425
Physiol Rev. 2005 Jan;85(1):373-422
pubmed: 15618484
PLoS One. 2018 Jun 22;13(6):e0199319
pubmed: 29933368
J Voice. 2002 Jun;16(2):172-81
pubmed: 12150370
J Allergy Clin Immunol. 2005 Oct;116(4):924-6
pubmed: 16210072
Clin Transl Allergy. 2018 May 30;8:20
pubmed: 29997887
Respir Physiol Neurobiol. 2008 Nov 30;163(1-3):208-13
pubmed: 18635403
Intensive Care Med Exp. 2021 Mar 17;9(1):8
pubmed: 33728866
Nat Rev Dis Primers. 2022 Jun 30;8(1):45
pubmed: 35773287
Am Rev Respir Dis. 1990 Jul;142(1):143-6
pubmed: 2368961
Sci Rep. 2022 Mar 29;12(1):4599
pubmed: 35351914
Head Neck. 2017 Dec;39(12):2481-2487
pubmed: 28990261
Cell Mol Life Sci. 2015 Oct;72(19):3637-52
pubmed: 26068443
QRB Discov. 2022 Apr 22;3:e6
pubmed: 37564950
Biophys J. 2010 Jan 6;98(1):57-66
pubmed: 20085719
Sci Signal. 2013 Jun 11;6(279):ra46
pubmed: 23757023
Lancet. 2015 Mar 28;385(9974):1198-205
pubmed: 25467586
Genes (Basel). 2021 Mar 22;12(3):
pubmed: 33810137
Environ Int. 2018 Dec;121(Pt 2):1058-1065
pubmed: 30389384
PLoS One. 2019 Sep 6;14(9):e0221330
pubmed: 31490971
J Appl Physiol (1985). 2022 Apr 1;132(4):1031-1040
pubmed: 35201932
MMWR Surveill Summ. 2021 Sep 17;70(5):1-32
pubmed: 34529643
Cell Physiol Biochem. 2011;28(2):289-96
pubmed: 21865736
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17383-8
pubmed: 15583121
Curr Opin Allergy Clin Immunol. 2009 Apr;9(2):154-60
pubmed: 19326508
J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):2087-2095
pubmed: 29729441
Int J Sports Med. 1995 May;16(4):209-13
pubmed: 7657412
Am J Public Health. 2017 Sep;107(9):1387-1394
pubmed: 28727528
Annu Rev Virol. 2020 Sep 29;7(1):83-101
pubmed: 32196426
Children (Basel). 2022 Apr 18;9(4):
pubmed: 35455621
Mol Front J. 2021;5(1-2):1-4
pubmed: 35372791
Annu Rev Med. 2007;58:157-70
pubmed: 17217330
Sci Rep. 2020 Jun 12;10(1):9593
pubmed: 32533079
Purinergic Signal. 2022 Sep;18(3):289-305
pubmed: 35727480
Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202521119
pubmed: 35605123
Q Rev Biophys. 2019 Nov 27;52:e13
pubmed: 31771669
Int J Mol Sci. 2021 Mar 25;22(7):
pubmed: 33806154
Lancet Infect Dis. 2018 Nov;18(11):1191-1210
pubmed: 30243584
Lancet Respir Med. 2013 Jul;1(5):414-22
pubmed: 24429206
Am J Respir Cell Mol Biol. 2017 Mar;56(3):372-382
pubmed: 27814452
Front Physiol. 2021 Jun 08;12:649497
pubmed: 34168568
J Appl Physiol (1985). 1988 May;64(5):1851-7
pubmed: 3391888
Ann Biomed Eng. 2014 Oct;42(10):2117-31
pubmed: 25081386
Rhinology. 2006 Mar;44(1):74-7
pubmed: 16550955
PLoS One. 2020 Sep 18;15(9):e0238339
pubmed: 32946453
Cough. 2011 Oct 14;7(1):8
pubmed: 21999754
Materials (Basel). 2021 Apr 06;14(7):
pubmed: 33917489
J Allergy Clin Immunol. 2011 Feb;127(2):412-9
pubmed: 21167571
Bull Math Biol. 1985;47(4):565-89
pubmed: 4084692
Biophys J. 1974 Dec;14(12):957-82
pubmed: 4429773
J Clin Invest. 2000 May;105(10):1419-27
pubmed: 10811849
Front Physiol. 2012 May 22;3:146
pubmed: 22661953
Thorax. 1976 Dec;31(6):678-84
pubmed: 1013939
Eur Respir J. 2017 Feb 8;49(2):
pubmed: 28179439
Nature. 2008 Sep 11;455(7210):208-12
pubmed: 18784721
J Appl Physiol (1985). 2021 Mar 1;130(3):517-527
pubmed: 33300853
J Aerosol Med Pulm Drug Deliv. 2020 Aug;33(4):230-234
pubmed: 32552296