Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases.

AD CNS MS fibrin fibrinogen neurodegenerative disease

Journal

Frontiers in neuroscience

ISSN: 1662-4548

Titre abrégé: Front Neurosci

Pays: Switzerland

ID NLM: 101478481

Informations de publication

Date de publication:
2023

Historique:

received: 13 04 2023

accepted: 27 06 2023

medline: 2 8 2023

pubmed: 2 8 2023

entrez: 2 8 2023

Statut: epublish

Résumé

Neurodegenerative diseases are prevalent and currently incurable conditions that progressively impair cognitive, behavioral, and psychiatric functions of the central or peripheral nervous system. Fibrinogen, a macromolecular glycoprotein, plays a crucial role in the inflammatory response and tissue repair in the human body and interacts with various nervous system cells due to its unique molecular structure. Accumulating evidence suggests that fibrinogen deposits in the brains of patients with neurodegenerative diseases. By regulating pathophysiological mechanisms and signaling pathways, fibrinogen can exacerbate the neuro-pathological features of neurodegenerative diseases, while depletion of fibrinogen contributes to the amelioration of cognitive function impairment in patients. This review comprehensively summarizes the molecular mechanisms and biological functions of fibrinogen in central nervous system cells and neurodegenerative diseases, including Alzheimer's disease, Multiple Sclerosis, Parkinson's disease, Vascular dementia, Huntington's disease, and Amyotrophic Lateral Sclerosis. Additionally, we discuss the potential of fibrinogen-related treatments in the management of neurodegenerative disorders.

Identifiants

DOI: 10.3389/fnins.2023.1197094 PMID: 37529232 PMC: PMC10390316

pubmed: 37529232

doi: 10.3389/fnins.2023.1197094

pmc: PMC10390316

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1197094

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

J Cell Mol Med. 2009 Sep;13(9A):2911-25

pubmed: 18657226

Curr Neuropharmacol. 2022;20(6):1116-1143

pubmed: 34852742

Pharmacol Ther. 2013 Jun;138(3):311-22

pubmed: 23384597

J Neurotrauma. 2018 Oct 1;35(19):2259-2271

pubmed: 29609523

Anal Biochem. 1987 Apr;162(1):47-64

pubmed: 3605596

J Neurosci. 2010 Apr 28;30(17):5843-54

pubmed: 20427645

J Biomed Sci. 2020 Jan 6;27(1):18

pubmed: 31906949

Ann Neurol. 2014 Oct;76(4):594-608

pubmed: 25088017

Cell Mol Immunol. 2021 Nov;18(11):2489-2501

pubmed: 34594000

J Neuroimmunol. 1996 Dec;71(1-2):131-7

pubmed: 8982112

Nat Immunol. 2018 Nov;19(11):1212-1223

pubmed: 30323343

BMC Geriatr. 2022 May 28;22(1):464

pubmed: 35643439

Neurol Sci. 2022 Apr;43(4):2601-2609

pubmed: 34561786

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10488-10493

pubmed: 31068461

Neurobiol Aging. 2000 Mar-Apr;21(2):161-9

pubmed: 10867201

Brain. 2007 Nov;130(Pt 11):2800-15

pubmed: 17956913

Behav Brain Res. 2016 Mar 15;301:243-52

pubmed: 26756439

Front Aging Neurosci. 2013 May 09;5:19

pubmed: 23675346

J Thromb Haemost. 2009 Feb;7(2):355-9

pubmed: 19036059

J Exp Med. 2014 Jun 2;211(6):1049-62

pubmed: 24821909

Nat Commun. 2015 Sep 10;6:8164

pubmed: 26353940

Semin Immunopathol. 2012 Jan;34(1):43-62

pubmed: 22037947

Int J Mol Sci. 2022 Nov 14;23(22):

pubmed: 36430497

Curr Neuropharmacol. 2020;18(11):1106-1125

pubmed: 32484110

Neurobiol Dis. 2005 Dec;20(3):953-60

pubmed: 16039866

Dialogues Clin Neurosci. 2009;11(2):111-28

pubmed: 19585947

Biomolecules. 2022 Nov 23;12(12):

pubmed: 36551169

Ageing Res Rev. 2021 Jul;68:101333

pubmed: 33774194

Mol Interv. 2004 Jun;4(3):163-76

pubmed: 15210870

Eur J Neurol. 2018 Jan;25(1):24-34

pubmed: 28817209

Ann Neurol. 2015 Aug;78(2):160-77

pubmed: 25866151

Neurobiol Aging. 2014 Mar;35(3):511-9

pubmed: 24126163

Biochemistry. 2003 Aug 12;42(31):9365-73

pubmed: 12899623

Brain Res. 2009 Dec 8;1301:152-62

pubmed: 19748495

J Alzheimers Dis. 2020;77(4):1373-1382

pubmed: 32925057

J Alzheimers Dis. 2015;47(2):403-12

pubmed: 26401562

Front Aging Neurosci. 2019 Aug 27;11:210

pubmed: 31507404

Brain Res. 2012 Aug 21;1469:114-28

pubmed: 22750125

Exp Neurobiol. 2015 Dec;24(4):325-40

pubmed: 26713080

Nat Med. 2018 Mar;24(3):326-337

pubmed: 29400711

Front Neurosci. 2020 Jul 24;14:762

pubmed: 32792902

Lancet Neurol. 2022 May;21(5):480-493

pubmed: 35334233

J Am Coll Cardiol. 2019 Oct 15;74(15):1910-1923

pubmed: 31601371

Acta Neuropathol. 2013 Jan;125(1):111-20

pubmed: 22941226

Neuron. 2019 Mar 20;101(6):1099-1108.e6

pubmed: 30737131

Int J Mol Sci. 2022 May 25;23(11):

pubmed: 35682615

Biomolecules. 2021 Sep 18;11(9):

pubmed: 34572594

Ann Neurol. 2017 Aug;82(2):259-270

pubmed: 28719020

Nat Neurosci. 2008 Apr;11(4):420-2

pubmed: 18344992

Neurobiol Dis. 2012 Jan;45(1):438-49

pubmed: 21946335

J Clin Invest. 2018 Feb 1;128(2):556-563

pubmed: 29388925

J Thromb Haemost. 2016 May;14(5):995-1007

pubmed: 26613657

Neurosci Biobehav Rev. 2020 May;112:353-360

pubmed: 32081688

Mech Ageing Dev. 2001 Nov;122(16):1971-83

pubmed: 11589915

Science. 1985 Dec 20;230(4732):1388-91

pubmed: 4071058

Lancet. 2021 Jun 12;397(10291):2284-2303

pubmed: 33848468

Curr Med Chem. 2007;14(27):2925-36

pubmed: 18045138

Haemostasis. 1996 Oct;26 Suppl 4:331-9

pubmed: 8979138

J Exp Med. 2007 Mar 19;204(3):571-82

pubmed: 17339406

J Cereb Blood Flow Metab. 2018 Jan;38(1):103-115

pubmed: 28151041

Neuron. 2002 Mar 14;33(6):861-75

pubmed: 11906694

J Neurophysiol. 2020 Aug 1;124(2):536-543

pubmed: 32697670

Biochemistry. 2002 Oct 29;41(43):12942-51

pubmed: 12390020

Adv Protein Chem. 2005;70:247-99

pubmed: 15837518

Acta Neuropathol. 2008 Jun;115(6):599-609

pubmed: 18369648

J Clin Pathol. 2019 Dec;72(12):817-824

pubmed: 31366633

Int J Mol Sci. 2021 Feb 27;22(5):

pubmed: 33673626

J Cell Biol. 2000 May 29;149(5):1157-66

pubmed: 10831618

J Neuroimmunol. 2016 Aug 15;297:159-68

pubmed: 27397090

CNS Neurosci Ther. 2023 May;29(5):1405-1422

pubmed: 36756722

Nat Commun. 2012;3:1227

pubmed: 23187627

Blood. 2016 Aug 25;128(8):1144-51

pubmed: 27389717

J Med Chem. 2013 Apr 25;56(8):3121-47

pubmed: 23458846

Blood. 2000 Oct 15;96(8):2793-802

pubmed: 11023513

ACS Chem Neurosci. 2022 Apr 6;13(7):1030-1045

pubmed: 35200010

Blood. 2017 May 4;129(18):2547-2556

pubmed: 28242605

J Exp Med. 2012 Mar 12;209(3):521-35

pubmed: 22393127

J Int Med Res. 2020 Feb;48(2):300060520902578

pubmed: 32093517

Antioxidants (Basel). 2021 Dec 31;11(1):

pubmed: 35052606

Neuropathol Appl Neurobiol. 2011 Feb;37(1):75-93

pubmed: 20946241

Int Immunopharmacol. 2019 Jul;72:473-478

pubmed: 31039464

Nat Neurosci. 2018 Oct;21(10):1300-1309

pubmed: 30258237

Methods Enzymol. 1976;45:214-23

pubmed: 1011993

J Biophys Biochem Cytol. 1959 Jan 25;5(1):11-6

pubmed: 13630928

Autoimmun Rev. 2016 Dec;15(12):1210

pubmed: 27725149

Eur Heart J. 2018 Feb 7;39(6):453-460

pubmed: 29077849

J Physiol. 2016 Oct 15;594(20):5941-5957

pubmed: 27121987

J Neurosci Res. 2011 May;89(5):718-28

pubmed: 21337372

Neuroepidemiology. 2010;34(1):50-4

pubmed: 19940513

J Cereb Blood Flow Metab. 2013 Aug;33(8):1251-8

pubmed: 23652625

Front Cell Neurosci. 2015 Sep 16;9:354

pubmed: 26441525

Stroke. 2009 Jul;40(7):2601-6

pubmed: 19443808

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6698-703

pubmed: 15096619

J Stroke Cerebrovasc Dis. 2021 Aug;30(8):105864

pubmed: 34062312

Nature. 1993 Jul 22;364(6435):362

pubmed: 8332197

Neuron. 2017 Dec 6;96(5):1003-1012.e7

pubmed: 29103804

J Neuroimmunol. 1997 Aug;77(2):185-94

pubmed: 9258249

Nat Rev Neurosci. 2018 May;19(5):283-301

pubmed: 29618808

J Exp Med. 2017 Nov 6;214(11):3151-3169

pubmed: 29061693

Mult Scler Relat Disord. 2020 Nov;46:102509

pubmed: 32977072

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11814-9

pubmed: 17606926

Neurosurgery. 2014 Sep;75(3):276-85; discussion 285

pubmed: 24867207

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21812-7

pubmed: 21098282

Blood. 2007 Mar 1;109(5):1971-4

pubmed: 17082318

Nature. 2008 Feb 28;451(7182):1076-81

pubmed: 18278032

Annu Rev Pathol. 2022 Jan 24;17:121-139

pubmed: 34606377

Ann Neurol. 2014 Feb;75(2):303-8

pubmed: 24740641

J Cereb Blood Flow Metab. 2015 May;35(5):747-50

pubmed: 25757748

Thromb Haemost. 2022 Aug;122(8):1265-1278

pubmed: 34902868

Neural Regen Res. 2021 Aug;16(8):1556-1557

pubmed: 33433480

Brain. 2001 Oct;124(Pt 10):1978-88

pubmed: 11571216

Structure. 2016 Nov 1;24(11):1907-1917

pubmed: 27692965

Blood. 2012 Apr 5;119(14):3342-51

pubmed: 22238323

Biochemistry. 2007 Aug 7;46(31):9133-42

pubmed: 17630702

J Clin Invest. 2004 Jun;113(11):1596-606

pubmed: 15173886

Neuron. 2010 Jun 10;66(5):695-709

pubmed: 20547128

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):e13-e21

pubmed: 28228446

Brain Pathol. 2013 May;23(3):303-10

pubmed: 23126372

Asian J Psychiatr. 2017 Oct;29:59-62

pubmed: 29061429

Eur J Clin Invest. 2002 May;32(5):360-71

pubmed: 12027877

Neurobiol Aging. 2015 Feb;36(2):608-17

pubmed: 25475538

J Exp Med. 2007 Aug 6;204(8):1999-2008

pubmed: 17664291