Homologous basic helix-loop-helix transcription factors induce distinct deformations of torsionally-stressed DNA: a potential transcription regulation mechanism.
Basic helix–loop–helix transcription factors
DNA deformation
DNA–protein interactions
molecular dynamics simulations
torsionally-stressed DNA
Journal
QRB discovery
ISSN: 2633-2892
Titre abrégé: QRB Discov
Pays: England
ID NLM: 101772102
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
01
2022
revised:
24
05
2022
accepted:
30
05
2022
medline:
10
6
2022
pubmed:
10
6
2022
entrez:
2
8
2023
Statut:
epublish
Résumé
Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcription factors (TFs) to DNA. Despite the importance, the mechanistic details on how torsional stress impacts the TFs-DNA complexation remain scarce. Herein, we address the impact of torsional stress on DNA complexation with homologous human basic helix-loop-helix (BHLH) hetero- and homodimers: MycMax, MadMax and MaxMax. The three TF dimers exhibit specificity towards the same DNA consensus sequence, the
Identifiants
pubmed: 37529292
doi: 10.1017/qrd.2022.5
pii: S2633289222000059
pmc: PMC10392670
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e4Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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