Amortized Inference for Heterogeneous Reconstruction in Cryo-EM.
Journal
Advances in neural information processing systems
ISSN: 1049-5258
Titre abrégé: Adv Neural Inf Process Syst
Pays: United States
ID NLM: 9607483
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life. The algorithmic challenge of jointly estimating the poses, 3D structure, and conformational heterogeneity of a biomolecule from millions of noisy and randomly oriented 2D projections in a computationally efficient manner, however, remains unsolved. Our method, cryoFIRE, performs
Types de publication
Journal Article
Langues
eng
Pagination
13038-13049Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM144965
Pays : United States
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