Real-World Analysis of Clinical Characteristics and Survival Outcomes in Patients With Extensive-Stage SCLC Treated With First-Line Chemoimmunotherapy.
Chemoimmunotherapy
Clinical characteristics
Small cell lung cancer
Survival
Journal
JTO clinical and research reports
ISSN: 2666-3643
Titre abrégé: JTO Clin Res Rep
Pays: United States
ID NLM: 101769967
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
06
03
2023
revised:
17
05
2023
accepted:
16
06
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
epublish
Résumé
There are no clinically validated prognostic biomarkers in the management of extensive-stage SCLC (ES-SCLC). We explored the association between clinical characteristics and survival outcomes in patients with ES-SCLC treated with chemoimmunotherapy. In this retrospective cohort study, patients with ES-SCLC treated with first-line platinum-etoposide chemotherapy and atezolizumab were identified from medical records. Pretreatment clinical characteristics, biochemical parameters, and tumor and treatment characteristics were collected. Univariate and multivariate Cox regression were used to evaluate treatment effect on progression-free survival (PFS) and overall survival (OS). We evaluated 75 patients in total. The median PFS and OS were 6.1 months and 9.2 months, respectively. Statistically significant associations were found with lower lactate dehydrogenase and improved OS (hazard ratio [HR] = 1.0, 95% confidence interval [CI]: 1.0-1.01, This study highlights the important effect of chemotherapy on survival. Furthermore, the association between lactate dehydrogenase and neutrophil-to-lymphocyte ratio on survival further suggests that baseline tumor burden and optimizing sarcopenia are important factors for clinicians to consider as we seek to develop personalized treatment for this disease.
Identifiants
pubmed: 37529402
doi: 10.1016/j.jtocrr.2023.100544
pii: S2666-3643(23)00087-5
pmc: PMC10388193
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100544Informations de copyright
Crown Copyright © 2023 Published by Elsevier Inc. on behalf of the International Association for the Study of Lung Cancer.
Références
ESMO Open. 2022 Apr;7(2):100408
pubmed: 35279527
JPEN J Parenter Enteral Nutr. 2019 Feb;43(2):181-193
pubmed: 30288759
J Hematol Oncol. 2019 Jun 28;12(1):67
pubmed: 31253167
Cancer Detect Prev. 1998;22(4):293-304
pubmed: 9674872
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Cancer. 2015 Mar 1;121(5):664-72
pubmed: 25336398
Nat Rev Cancer. 2019 May;19(5):289-297
pubmed: 30926931
J Thorac Oncol. 2022 Sep;17(9):1122-1129
pubmed: 35764236
Nat Med. 2018 Sep;24(9):1441-1448
pubmed: 30082870
ANZ J Surg. 2021 May;91(5):E292-E297
pubmed: 33682264
Oncotarget. 2019 Nov 12;10(61):6604-6622
pubmed: 31762941
Cancer Cell. 2018 May 14;33(5):853-861.e4
pubmed: 29731394
J Gastrointest Surg. 2018 Oct;22(10):1697-1708
pubmed: 29855867
Acta Oncol. 1999;38(8):1011-5
pubmed: 10665754
J Natl Cancer Inst. 2014 May 29;106(6):dju124
pubmed: 24875653
J Clin Oncol. 2021 Feb 20;39(6):619-630
pubmed: 33439693
Tumour Biol. 2016 Oct;37(10):14083-14088
pubmed: 27511116
Cancer Cell. 2021 Mar 8;39(3):346-360.e7
pubmed: 33482121
Cancer Manag Res. 2019 May 07;11:4185-4200
pubmed: 31190988
J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1165-1174
pubmed: 31389674
Front Immunol. 2019 Jul 17;10:1654
pubmed: 31379850
Cancer Biomark. 2016;16(3):415-23
pubmed: 27062698
Clinics (Sao Paulo). 2015 Jul;70(7):524-30
pubmed: 26222823
Cancers (Basel). 2019 Nov 25;11(12):
pubmed: 31769421
J Thorac Oncol. 2020 Dec;15(12):1823-1835
pubmed: 33011388
Metabolism. 1994 Jun;43(6):697-705
pubmed: 7515458
J Clin Oncol. 2020 Jul 20;38(21):2369-2379
pubmed: 32468956
Lancet. 2019 Nov 23;394(10212):1929-1939
pubmed: 31590988
Sci Rep. 2015 Apr 22;5:9800
pubmed: 25902419
Nutr J. 2010 Dec 22;9:69
pubmed: 21176210
N Engl J Med. 2018 Dec 6;379(23):2220-2229
pubmed: 30280641
Clin Sci (Lond). 1999 Aug;97(2):215-23
pubmed: 10409477
JAMA Oncol. 2023 Mar 1;9(3):419-429
pubmed: 36520421
Am J Clin Nutr. 1996 Oct;64(4):552-8
pubmed: 8839499
Nat Commun. 2021 Feb 1;12(1):729
pubmed: 33526794