Adult T-Cell Lymphoma (ATL) With Erythroderma in Indolent Human T-Lymphotropic Virus Type I (HTLV-1) Infection.
adult t-cell lymphoma/leukemia (atl)
diagnosis and treatment of htlv-1 infection
erythroderma associated with adult t-cell lymphoma
mature t-cell malignancy
rare lymphoproliferative neoplasm
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
accepted:
01
07
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
epublish
Résumé
Adult T-cell lymphoma (ATL) is a hematological malignancy of CD4+ mature T-lymphocytes commonly associated with chronic human T-lymphotropic virus type I (HTLV-1) infection. Chronic HTLV-1 infection induces oncogenic mutations in CD4+ T-cells, leading to an acute malignant transformation of host cells. Atypically, ATL presents with dermatological and pulmonary symptoms consistent with a "smoldering" disease pattern. We present a case of a 78-year-old male patient with chronic generalized malaise, progressively worsening shortness of breath, and diffuse erythroderma, who was diagnosed with ATL secondary to chronic indolent HTLV-1 infection. We evaluate the multisystemic clinical signs associated with ATL, the comprehensive clinical investigations required to reach a conclusive diagnosis, and the options for long-term clinical management.
Identifiants
pubmed: 37529824
doi: 10.7759/cureus.41264
pmc: PMC10390346
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e41264Informations de copyright
Copyright © 2023, Qasim et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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