Group B streptococcal prevalence in internal organs and placentas of deceased neonates and stillbirths in South Asia.
South Asia
group B streptococcus
neonatal deaths
prevalence
stillbirths
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
13
04
2023
accepted:
30
06
2023
medline:
13
11
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Group B streptococcus (GBS) has been associated with adverse pregnancy outcomes, but few prospective studies have assessed its prevalence in low- and middle-income country settings. We sought to evaluate the prevalence of GBS by polymerase chain reaction (PCR) in internal organ tissues and placentas of deceased neonates and stillbirths. This was a prospective, observational study. The study was conducted in hospitals in India and Pakistan. Pregnant women with stillbirths or preterm births were recruited at delivery, as was a group of women with term, live births, to serve as a control group. A rectovaginal culture was collected from the women in Pakistan to assess GBS carriage. Using PCR, we evaluated GBS in various tissues of stillbirths and deceased neonates and their placentas, as well as the placentas of live-born preterm and term control infants. GBS identified by PCR in various tissues and the placentas; rate of stillbirths and 28-day neonatal deaths. The most obvious finding from this series of analyses from India and Pakistan was that no matter the country, the condition of the subject, the tissue studied or the methodology used, the prevalence of GBS was low, generally ranging between 3% and 6%. Among the risk factors evaluated, only GBS positivity in primigravidae was increased. GBS diagnosed by PCR was identified in <6% of internal organs of stillbirths and neonatal deaths, and their placentas, and control groups in South Asian sites. This is consistent with other reports from South Asia and is lower than the reported GBS rates from the USA, Europe and Africa.
Identifiants
pubmed: 37530593
doi: 10.1111/1471-0528.17614
doi:
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-60Subventions
Organisme : Bill and Melinda Gates Foundation
Investigateurs
Mahantesh B Nagmoti
(MB)
Gayathri H Aradhya
(GH)
Naveen Nadig
(N)
Varun Kusgur
(V)
Chaitali R Raghoji
(CR)
E S Siddartha
(ES)
Lingaraja Gowda C Patil
(LGC)
Sneharoopa Pujar
(S)
Shobha Dhananjaya
(S)
B Sarvamangala
(B)
Veena Prakash
(V)
G K Mangala
(GK)
K S Rajashekha
(KS)
K Byranahalli Sunilkuma
(KB)
Vardendra Kulkarni
(V)
T S Nagaraj
(TS)
M U Jeevika
(MU)
Upendra Kumae Joish
(UK)
Reddy R Harikiran
(RR)
Shiyam Sunder
(S)
Masood Kadir
(M)
Afia Zafar
(A)
Zeeshan Uddin
(Z)
Waseem Mirza
(W)
Jamal Raza
(J)
Jai Prakash
(J)
Furqan Haider
(F)
Lindsay Parlberg
(L)
Janet L Moore
(JL)
Suchita Parepelli
(S)
Elizabeth M McCiure
(EM)
Carla Bann
(C)
Robert M Silver
(RM)
Informations de copyright
© 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
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