The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma.
endocytosis
mitotic checkpoint
raphe neurons
recycling endosome
serotonin transporter
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
09 10 2023
09 10 2023
Historique:
revised:
23
06
2023
received:
09
06
2021
accepted:
14
07
2023
medline:
10
10
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Monoamine transporters retrieve serotonin (SERT), dopamine (DAT), and norepinephrine (NET) from the synaptic cleft. Transporter internalization contributes to the regulation of their surface expression. Clathrin-mediated endocytosis of plasma membrane proteins requires adaptor protein-2 (AP2), which recruits cargo to the nascent clathrin cage. However, the intracellular portions of monoamine transporters are devoid of a conventional AP2-binding site. Here, we identify a MAD2 (mitotic arrest deficient-2) interaction motif in the C-terminus of SERT, which binds the closed conformation of MAD2 and allows for the recruitment of two additional mitotic spindle assembly checkpoint (SAC) proteins, BubR1 and p31
Identifiants
pubmed: 37530743
doi: 10.15252/embr.202153408
pmc: PMC10561363
doi:
Substances chimiques
Serotonin Plasma Membrane Transport Proteins
0
Mad2 Proteins
0
Nuclear Proteins
0
Cell Cycle Proteins
0
Adaptor Proteins, Signal Transducing
0
Clathrin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e53408Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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