Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
02 10 2023
02 10 2023
Historique:
received:
17
06
2022
revised:
14
02
2023
accepted:
24
07
2023
pmc-release:
02
04
2024
medline:
5
10
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Lung cancer is a complex polygenic disorder. Analysis with Mendelian randomization (MR) allows for genetically predicted risks to be estimated between exposures and outcomes. We analyzed 345 heritable traits from the United Kingdom Biobank and estimated their associated effects on lung cancer outcomes using two sample MR. In addition to estimating effects with overall lung cancer, adenocarcinoma, small cell lung cancer, and squamous cell lung cancers, we performed conditional effect modeling with multivariate MR (MVMR) and the traits of alcohol use, smoking initiation, average pre-tax income, and educational attainment. Univariate MR provided evidence for increased age at first sexual intercourse (OR, 0.55; P = 6.15 × 10-13), educational attainment (OR, 0.24; P = 1.07 × 10-19), average household income (OR, 0.58; P = 7.85 × 10-05), and alcohol usually taken with meals (OR, 0.19; P = 1.06 × 10-06) associating with decreased odds of overall lung cancer development. In contrast, a lack of additional educational attainment (OR, 8.00; P = 3.48 × 10-12), body mass index (OR, 1.28; P = 9.00 × 10-08), pack years smoking as a proportion of life span (OR, 9.93; P = 7.96 × 10-12), and weekly beer intake (OR, 3.48; P = 4.08 × 10-07) were associated with an increased risk of overall lung cancer development. Many heritable traits associated with an increased or inverse risk of lung cancer development. Effects vary based on histologic subtype and conditional third trait exposures. We identified several heritable traits and presented their genetically predictable impact on lung cancer development, providing valuable insights for consideration.
Identifiants
pubmed: 37530747
pii: 728186
doi: 10.1158/1055-9965.EPI-22-0698
pmc: PMC10651112
mid: NIHMS1923618
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1421-1435Subventions
Organisme : NCI NIH HHS
ID : R01 CA139020
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148127
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA203654
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243483
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA243483
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES027801
Pays : United States
Informations de copyright
©2023 American Association for Cancer Research.
Références
Semin Arthritis Rheum. 2021 Jun;51(3):565-575
pubmed: 33932788
Stat Methods Med Res. 2007 Aug;16(4):309-30
pubmed: 17715159
Int J Epidemiol. 2013 Oct;42(5):1497-501
pubmed: 24159078
Curr Biol. 2016 Nov 21;26(22):3083-3089
pubmed: 27818178
Am J Epidemiol. 2015 Feb 15;181(4):251-60
pubmed: 25632051
Nature. 2016 May 11;533(7604):539-42
pubmed: 27225129
PLoS Med. 2020 Jul 23;17(7):e1003178
pubmed: 32701947
Cancer Med. 2021 Jul;10(13):4587-4603
pubmed: 34076349
J Thorac Dis. 2020 Oct;12(10):5299-5302
pubmed: 33209364
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15273-8
pubmed: 25288728
Cells. 2021 Feb 15;10(2):
pubmed: 33671849
Genet Epidemiol. 2020 Jun;44(4):313-329
pubmed: 32249995
Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):126-135
pubmed: 27697780
BMC Med. 2022 Feb 2;20(1):41
pubmed: 35105367
PLoS Genet. 2021 Apr 19;17(4):e1009455
pubmed: 33872308
Int J Cancer. 2021 Mar 1;148(5):1077-1086
pubmed: 32914876
Nat Commun. 2020 Jan 17;11(1):376
pubmed: 31953392
J Cancer Res Clin Oncol. 2021 Oct;147(10):2837-2849
pubmed: 34318357
J Cancer Res Clin Oncol. 2021 Jan;147(1):177-181
pubmed: 32989605
BMC Med. 2021 Dec 15;19(1):320
pubmed: 34906131
Mol Genet Genomics. 2020 May;295(3):537-561
pubmed: 32048005
BMJ. 2017 Oct 31;359:j4761
pubmed: 29089348
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Elife. 2018 May 30;7:
pubmed: 29846171
PLoS One. 2017 Jun 8;12(6):e0177875
pubmed: 28594918
NPJ Sci Learn. 2017 Feb 1;2:4
pubmed: 30631451
Int J Epidemiol. 2019 Jun 1;48(3):713-727
pubmed: 30535378
J Thorac Oncol. 2021 Jul;16(7):1127-1135
pubmed: 33852959
Curr Epidemiol Rep. 2020 Jun;7(2):104-112
pubmed: 33552841
Stat Methods Med Res. 2017 Oct;26(5):2333-2355
pubmed: 26282889
J Cancer Res Clin Oncol. 2021 Jan;147(1):139-151
pubmed: 32965542
Thorax. 2020 Nov;75(11):955-964
pubmed: 32855344
PLoS Genet. 2020 Nov 2;16(11):e1009105
pubmed: 33137120
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Transl Lung Cancer Res. 2021 Apr;10(4):1720-1733
pubmed: 34012788
Nat Rev Genet. 2019 Oct;20(10):567-581
pubmed: 31171865
Ann Glob Health. 2019 Jan 22;85(1):
pubmed: 30741509
J Immunol Res. 2021 Jun 21;2021:1893882
pubmed: 34239941
Nat Biotechnol. 2008 Mar;26(3):256
pubmed: 18327223
Curr Epidemiol Rep. 2018 Jun;5(2):184-196
pubmed: 30034993
Hum Mol Genet. 2014 Sep 15;23(R1):R89-98
pubmed: 25064373
Cancer Epidemiol Biomarkers Prev. 2021 Jun;30(6):1156-1164
pubmed: 33771847
JNCI Cancer Spectr. 2021 Apr 19;5(3):
pubmed: 34222791
JTO Clin Res Rep. 2020 Apr 15;1(3):100042
pubmed: 34589939
Cell. 2017 Jun 15;169(7):1177-1186
pubmed: 28622505
Stat Med. 2021 Nov 10;40(25):5434-5452
pubmed: 34338327
Mult Scler Relat Disord. 2021 Jun;51:102927
pubmed: 33812221
Int J Epidemiol. 2019 Jun 1;48(3):743-750
pubmed: 31219597
Nat Genet. 2017 Jul;49(7):1126-1132
pubmed: 28604730
Sci Rep. 2021 Sep 2;11(1):17606
pubmed: 34475499
Front Public Health. 2021 Jun 03;9:673451
pubmed: 34150709
PLoS One. 2019 Sep 23;14(9):e0222362
pubmed: 31545794
Ann Transl Med. 2021 Feb;9(3):263
pubmed: 33708890
PLoS Genet. 2017 Nov 17;13(11):e1007081
pubmed: 29149188
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Curr Epidemiol Rep. 2017;4(4):330-345
pubmed: 29226067
Front Genet. 2021 Nov 24;12:742718
pubmed: 34899835
Nat Genet. 2019 Feb;51(2):237-244
pubmed: 30643251
Hum Mol Genet. 2018 Aug 1;27(R2):R195-R208
pubmed: 29771313
Sci Rep. 2021 Sep 2;11(1):17559
pubmed: 34475455
Eur J Epidemiol. 2016 Sep;31(9):879-92
pubmed: 27061578
Int J Epidemiol. 2020 Aug 1;49(4):1406-1407
pubmed: 31628798
Eur J Hum Genet. 2022 Jun;30(6):653-660
pubmed: 35082398