Late-onset distal-apical intracorneal ring-segments keratopathy: an analysis of a large sample in a multicenter study.
ICRS complications
Intracorneal ring-segments
Keratitis
Keratoconus
Keratopathy
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
11
04
2022
accepted:
22
06
2023
medline:
26
9
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
To review the prevalence and describe the characteristics, of cases with late-onset intracorneal ring segments (ICRS) keratopathy in a multicenter study. A retrospective multicentric case-series study was performed in a specialized keratoconus service, from Buenos Aires, Argentina. An electronic clinical chart from patients with ICRS keratopathy between January 1999 and January 2019 was reviewed. We included cases with late-onset distal-apical ICRS keratopathy, which was defined as a persistent corneal lesion developed 12 months or later after implantation, located over, around, or closer to the ICRS. All the surgeries were performed by a manual corneal tunnel creation technique. Samples were taken to rule out infectious etiology. From 5217 eyes that underwent ICRS implantation, 13 cases (0.24%) were detected. The keratopathy onset was 72 ± 42.98 months (29-133) after ICRS implantation. Cultures were negative in all cases. An ICRS exchange was made for five cases in stage I and four in stage II. Four cases presented with partial ICRS extrusion in stage III. ICRS exchange was possible in two of them and a penetration keratoplasty was necessary for the rest. All cases remained stable 1 year after surgical procedures. A late-onset distal-apical ICRS keratopathy was detected with low prevalence (0.24%) in a large sample. It was classified into three stages according to its severity. Different treatments were selected for each stage, obtaining stable results 1 year after treatment.
Identifiants
pubmed: 37531002
doi: 10.1007/s10792-023-02793-0
pii: 10.1007/s10792-023-02793-0
doi:
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3923-3933Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Piñero DP, Alio JL (2010) Intracorneal ring segments in ectatic corneal disease - a review. Clin Exp Ophthalmol 38:154–167. https://doi.org/10.1111/j.1442-9071.2010.02197.x
doi: 10.1111/j.1442-9071.2010.02197.x
pubmed: 20398105
Ganesh S, Shetty R, D’Souza S, Ramachandran S, Kurian M (2013) Intrastromal corneal ring segments for management of keratoconus. Indian J Ophthalmol 61:451–455. https://doi.org/10.4103/0301-4738.116065
doi: 10.4103/0301-4738.116065
pubmed: 23925336
pmcid: 3775086
Rabinowitz YS, Li X, Ignacio TS, Maguen E (2006) Intacs inserts using the femtosecond laser compared to the mechanical spreader in the treatment of keratoconus. J Refract Surg 22:764–771. https://doi.org/10.3928/1081-597X-20061001-06
doi: 10.3928/1081-597X-20061001-06
pubmed: 17061713
Kubaloglu A, Sari ES, Cinar Y, Cingu K, Koytak A, Coşkun E, Ozertürk Y (2010) Comparison of mechanical and femtosecond laser tunnel creation for intrastromal corneal ring segment implantation in keratoconus: prospective randomized clinical trial. J Cataract Refract Surg 36:1556–1561. https://doi.org/10.1016/j.jcrs.2010.04.028
doi: 10.1016/j.jcrs.2010.04.028
pubmed: 20692570
Coskunseven E, Kymionis GD, Tsiklis NS, Atun S, Arslan E, Siganos CS, Jankov M, Pallikaris IG (2011) Complications of intrastromal corneal ring segment implantation using a femtosecond laser for channel creation: a survey of 850 eyes with keratoconus. Acta Ophthalmol 89:54–57. https://doi.org/10.1111/j.1755-3768.2009.01605.x
doi: 10.1111/j.1755-3768.2009.01605.x
pubmed: 19681760
Schanzlin DJ, Abbott RL, Asbell PA, Assil KK, Burris TE, Durrie DS, Fouraker BD, Lindstrom RL, McDonald JE 2nd, Verity SM, Waring GO 3rd (2001) Two-year outcomes of intrastromal corneal ring segments for the correction of myopia. Ophthalmology 108:1688–1694. https://doi.org/10.1016/s0161-6420(01)00692-3
doi: 10.1016/s0161-6420(01)00692-3
pubmed: 11535474
Mounir A, Radwan G, Farouk MM, Mostafa EM (2018) Femtosecond-assisted intracorneal ring segment complications in keratoconus: from novelty to expertise. Clin Ophthalmol 12:957–964. https://doi.org/10.2147/OPTH.S166538
doi: 10.2147/OPTH.S166538
pubmed: 29872254
pmcid: 5973306
Cosar CB, Sridhar MS, Sener B (2009) Late onset of deep corneal vascularization: a rare complication of intrastromal corneal ring segments for keratoconus. Eur J Ophthalmol 19:298–300. https://doi.org/10.1177/112067210901900222
doi: 10.1177/112067210901900222
pubmed: 19253252
Levy J, Lifshitz T (2010) Keratitis after implantation of intrastromal corneal ring segments (Intacs) aided by femtosecond laser for keratoconus correction: case report and description of the literature. Eur J Ophthalmol 20:780–784. https://doi.org/10.1177/112067211002000422
doi: 10.1177/112067211002000422
pubmed: 20155711
Shehadeh-Masha’our R, Modi N, Barbara A, Garzozi HJ (2004) Keratitis after implantation of intrastromal corneal ring segments. J Cataract Refract Surg 30:1802–1804. https://doi.org/10.1016/j.jcrs.2004.01.034
doi: 10.1016/j.jcrs.2004.01.034
pubmed: 15313312
Bourges J-L, Trong TT, Ellies P, Briat B, Renard G (2003) Intrastromal corneal ring segments and corneal anterior stromal necrosis. J Cataract Refract Surg 29:1228–1230. https://doi.org/10.1016/S0886-3350(02)02036-9
doi: 10.1016/S0886-3350(02)02036-9
pubmed: 12842696
Hofling-Lima AL, Branco BC, Romano AC, Campos MQ, Moreira H, Miranda D, Kwitko S, de Freitas D, Casanova FH, Sartori M, Schor P, Souza LB (2004) Corneal infections after implantation of intracorneal ring segments. Cornea 23:547–549. https://doi.org/10.1097/01.ico.0000126434.95325.24 . Erratum in: Cornea. 2004; 23:table of contents. Casanova, Fabio [corrected to Casanova, Fabio H]
Bourcier T, Borderie V, Laroche L (2003) Late bacterial keratitis after implantation of intrastromal corneal ring segments. J Cataract Refract Surg 29:407–409. https://doi.org/10.1016/S0886-3350(02)01484-0
doi: 10.1016/S0886-3350(02)01484-0
pubmed: 12648660
Ferrer C, Alió JL, Montañés AU, Pérez-Santonja JJ, del Rio MA, de Toledo JA, Teus MA, Javaloy J (2010) Causes of intrastromal corneal ring segment explantation: clinicopathologic correlation analysis. J Cataract Refract Surg 36:970–977. https://doi.org/10.1016/j.jcrs.2009.12.042
doi: 10.1016/j.jcrs.2009.12.042
pubmed: 20494769
Chhadva P, Yesilirmak N, Cabot F, Yoo SH (2015) Intrastromal corneal ring segment explantation in patients with keratoconus: causes, technique, and outcomes. J Refract Surg 31:392–397. https://doi.org/10.3928/1081597X-20150521-05
doi: 10.3928/1081597X-20150521-05
pubmed: 26046706
Bautista-Llamas MJ, Sánchez-González MC, López-Izquierdo I, López-Muñoz A, Gargallo-Martínez B, De-Hita-Cantalejo C, Sánchez-González JM (2019) Complications and explantation reasons in intracorneal ring segments (ICRS) implantation: a systematic review. J Refract Surg 35:740–747. https://doi.org/10.3928/1081597X-20191010-02
doi: 10.3928/1081597X-20191010-02
pubmed: 31710377
Oatts JT, Savar L, Hwang DG (2017) Late extrusion of intrastromal corneal ring segments: a report of two cases. Am J Ophthalmol Case Rep 8:67–70
doi: 10.1016/j.ajoc.2017.10.004
pubmed: 29260121
pmcid: 5731710
Assil KK, Barrett AM, Fouraker BD, Schanzlin DJ (1995) One-year results of the intrastromal corneal ring in nonfunctional human eyes. Intrastromal Corneal Ring Study Group. Arch Ophthalmol 113:159–167
doi: 10.1001/archopht.1995.01100020041026
pubmed: 7864747
Torquetti L, Ferrara G, Almeida F, Cunha L, Araujo LP, Machado A, Marcelo Lyra J, Merayo-Lloves J, Ferrara P (2014) Intrastromal corneal ring segments implantation in patients with keratoconus: 10-year follow-up. J Refract Surg 30:22–26
doi: 10.3928/1081597X-20131217-02
pubmed: 24864323
Shajari M, Eberhardt E, Müller M, Al Khateeb G, Friderich S, Remy M, Kohnen T (2016) Effects of atopic syndrome on keratoconus. Cornea 35:1416–1420
doi: 10.1097/ICO.0000000000000935
pubmed: 27429082
Wisse RP, Kuiper JJ, Gans R, Imhof S, Radstake TR, Van der Lelij A (2015) Cytokine expression in keratoconus and its corneal microenvironment: a systematic review. Ocul Surf 13:272–283
doi: 10.1016/j.jtos.2015.04.006
pubmed: 26235733
D’Oria F, Abdelghany AA, Ledo N, Barraquer RI, Alio JL (2021) Incidence and reasons for intrastromal corneal ring segment explantation. Am J Ophthalmol 222:351–358. https://doi.org/10.1016/j.ajo.2020.09.041
doi: 10.1016/j.ajo.2020.09.041
pubmed: 33011155
D’Oria F, Alio JL, Martinez-Abad A, Izquierdo L Jr, Larco P Jr, Abdelghany AA (2022) Astigmatic change as a predictor of intrastromal corneal ring segment late extrusion. J Cataract Refract Surg 48:401–407. https://doi.org/10.1097/j.jcrs.0000000000000774
doi: 10.1097/j.jcrs.0000000000000774
pubmed: 34393182
Twa MD, Ruckhofer J, Kash RL, Costello M, Schanzlin DJ (2003) Histologic evaluation of corneal stroma in rabbits after intrastromal corneal ring implantation. Cornea 22:146–152. https://doi.org/10.1097/00003226-200303000-00014
doi: 10.1097/00003226-200303000-00014
pubmed: 12605051
Kugler LJ, Hill S, Sztipanovits D, Boerman H, Swartz TS, Wang MX (2011) Corneal melt of incisions overlying corneal ring segments: case series and literature review. Cornea 30:968–971. https://doi.org/10.1097/ICO.0b013e3182031ca0
doi: 10.1097/ICO.0b013e3182031ca0
pubmed: 21448065
Al-Aqaba MA, Dhillon VK, Mohammed I, Said DG, Dua HS (2019) Corneal nerves in health and disease. Prog Retin Eye Res 73:100762. https://doi.org/10.1016/j.preteyeres.2019.05.003
doi: 10.1016/j.preteyeres.2019.05.003
pubmed: 31075321
Flockerzi E, Daas L, Seitz B (2020) Structural changes in the corneal subbasal nerve plexus in keratoconus. Acta Ophthalmol 98(8):e928–e932. https://doi.org/10.1111/aos.14432
doi: 10.1111/aos.14432
pubmed: 32275356
Müller LJ, Vrensen GF, Pels L, Cardozo BN, Willekens B (1997) Architecture of human corneal nerves. Invest Ophthalmol Vis Sci 38:985–994
pubmed: 9112994
Cruzat A, Qazi Y, Hamrah P (2017) In vivo confocal microscopy of corneal nerves in health and disease. Ocul Surf 15:15–47. https://doi.org/10.1016/j.jtos.2016.09.004
doi: 10.1016/j.jtos.2016.09.004
pubmed: 27771327
Monteiro T, Alfonso JF, Freitas R, Franqueira N, Faria-Correira F, Ambrósio R, Madrid-Costa D (2019) Comparison of complication rates between manual and femtosecond laser-assisted techniques for intrastromal corneal ring segments implantation in keratoconus. Curr Eye Res 44:1291–1298. https://doi.org/10.1080/02713683.2019.1635165
doi: 10.1080/02713683.2019.1635165
pubmed: 31226888
Fariselli C, Vega-Estrada A, Arnalich-Montiel F, Alio JL (2020) Artificial neural network to guide intracorneal ring segments implantation for keratoconus treatment: a pilot study. Eye Vis (Lond) 7:20. https://doi.org/10.1186/s40662-020-00184-5
doi: 10.1186/s40662-020-00184-5
pubmed: 32292796
Peris-Martínez C, Dualde-Beltrán C, Fernández-López E, Roig-Revert MJ, Hernández-Díaz M, Piñero DP (2020) Effect of the variability in implantation depth of intracorneal ring segments using the femtosecond laser technology in corneal ectasia. Eur J Ophthalmol 30:668–675. https://doi.org/10.1177/1120672119852026
doi: 10.1177/1120672119852026
pubmed: 31113256