Light disrupts social memory via a retina-to-supraoptic nucleus circuit.
Intrinsically photosensitive retinal ganglion cells
melanopsin
oxytocin
social recognition memory
supraoptic nucleus
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
09 Oct 2023
09 Oct 2023
Historique:
revised:
19
07
2023
received:
16
01
2023
accepted:
20
07
2023
pmc-release:
02
08
2024
pubmed:
2
8
2023
medline:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
The formation of social memory between individuals of the opposite sex is crucial for expanding mating options or establishing monogamous pair bonding. A specialized neuronal circuit that regulates social memory could enhance an individual's mating opportunities and provide a parallel pathway for computing social behaviors. While the influence of light exposure on various forms of memory, such as fear and object memory, has been studied, its modulation of social recognition memory remains unclear. Here, we demonstrate that acute exposure to light impairs social recognition memory (SRM) in mice. Unlike sound and touch stimuli, light inhibits oxytocin neurons in the supraoptic nucleus (SON) via M1 SON-projecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and GABAergic neurons in the perinuclear zone of the SON (pSON). We further show that optogenetic activation of SON oxytocin neurons using channelrhodopsin is sufficient to enhance SRM performance, even under light conditions. Our findings unveil a dedicated neuronal circuit through which luminance affects SRM, utilizing a non-image-forming visual pathway, distinct from the canonical modulatory role of the oxytocin system.
Identifiants
pubmed: 37531065
doi: 10.15252/embr.202356839
pmc: PMC10561173
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e56839Subventions
Organisme : National Science and Technology Council (NSTC)
ID : 111-2636-B-002-021
Organisme : National Science and Technology Council (NSTC)
ID : 112-2321-B-002 -019
Organisme : National Science and Technology Council (NSTC)
ID : 106-2311-B-002-033-MY3
Informations de copyright
© 2023 The Authors.
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