Digital Manufacturing of Functional Ready-to-Use Microfluidic Systems.
3D printing
capillaric circuits
diagnostics
digital manufacturing
functional microfluidics
hydrophilic ink
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
19
07
2023
received:
25
04
2023
medline:
2
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Digital manufacturing (DM) holds great potential for microfluidics, but requirements for embedded conduits and high resolution beyond the capability of common manufacturing equipment, and microfluidic systems' dependence on peripheralshave limited its adoption. Capillaric circuits (CCs) are structurally encoded, self-contained microfluidic systems that operate and self-fill via precisely tailored hydrophilicity. CCs are heretofore hydrophilized in a plasma chamber, but which offers only transient hydrophilicity, lacks reproducibility, and limits CC design to open surface channels subsequently sealed with tape. Here, the additive DM of monolithic, fully functional, and intrinsically hydrophilic CCs is reported. CCs are 3D printed with commonly available light-engine-based 3D printers using poly(ethylene glycol)diacrylate-based ink co-polymerized with hydrophilic acrylic acid crosslinkers and optimized for hydrophilicity and printability. A new, robust capillary valve design and embedded conduits with circular cross-sections that prevent bubble trapping are presented, interwoven circuit architectures created, and CC use illustrated with an immunoassay. Finally, the external paper capillary pumps are eliminated by directly embedding the capillary pump in the chip as a porous gyroid structure, realizing fully functional, monolithic CCs. Thence, a digital file can be made into a CC by commonly available 3D printers in less than 30 min enabling low-cost, distributed DM of fully functional ready-to-use microfluidic systems.
Identifiants
pubmed: 37531202
doi: 10.1002/adma.202303867
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2303867Subventions
Organisme : FRQNT for the doctoral scholarship
ID : 268838
Organisme : Canada Research Chair in Bioengineering
ID : 232159
Organisme : FRQNT Postdoctoral Fellowship
ID : 267919
Informations de copyright
© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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