Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo.

Humans HIV-1 / genetics Transcriptome / genetics HIV Infections / genetics RNA, Viral

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
02 08 2023
Historique:
medline: 4 8 2023
pubmed: 2 8 2023
entrez: 2 8 2023
Statut: ppublish

Résumé

Host restriction factors play key roles in innate antiviral defense, but it remains poorly understood which of them restricts HIV-1 in vivo. Here, we used single-cell transcriptomic analysis to identify host factors associated with HIV-1 control during acute infection by correlating host gene expression with viral RNA abundance within individual cells. Wide sequencing of cells from one participant with the highest plasma viral load revealed that intracellular viral RNA transcription correlates inversely with expression of the gene

Identifiants

DOI: 10.1126/scitranslmed.adg0873 PMID: 37531416
pubmed: 37531416
doi: 10.1126/scitranslmed.adg0873
doi:

Substances chimiques

prothymosin alpha 0
RNA, Viral 0

Banques de données

figshare
['10.6084/m9.figshare.c.6288354']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg0873

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164570
Pays : United States

Auteurs

Aviva Geretz (A)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0003-2224-8368

Philip K Ehrenberg (PK)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-8695-4301

Robert J Clifford (RJ)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0001-8888-897X

Alexandre Laliberté (A)

Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
ORCID: 0000-0002-6526-4133

Caterina Prelli Bozzo (C)

Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
ORCID: 0009-0000-2763-102X

Daina Eiser (D)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.

Gautam Kundu (G)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0002-3924-5158

Lauren K Yum (LK)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0003-2439-561X

Richard Apps (R)

NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0001-5140-0141

Matthew Creegan (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0002-4205-466X

Mohamed Gunady (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0002-5027-9279

Shida Shangguan (S)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0003-4471-5318

Eric Sanders-Buell (E)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.

Carlo Sacdalan (C)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
ORCID: 0000-0002-5839-4837

Nittaya Phanuphak (N)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
ORCID: 0000-0002-0036-3165

Sodsai Tovanabutra (S)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.

Ronnie M Russell (RM)

Departments of Medicine and Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0003-1484-4207

Frederic Bibollet-Ruche (F)

Departments of Medicine and Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Merlin L Robb (ML)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0003-3949-9649

Nelson L Michael (NL)

Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Julie A Ake (JA)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-3831-5828

Sandhya Vasan (S)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0002-6378-6288

Denise C Hsu (DC)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
ORCID: 0000-0001-7530-0508

Beatrice H Hahn (BH)

Departments of Medicine and Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0002-9400-9887

Frank Kirchhoff (F)

Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
ORCID: 0000-0002-7052-2360

Rasmi Thomas (R)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-2116-2418

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Single-cell transcriptomics identifies...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Single-cell transcriptomics identifies...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Single-cell transcriptomics identifies...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Single-cell transcriptomics identifies...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Single-cell transcriptomics identifies...