Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens.
Antagonists & Inhibitors
Mastitis
Staphylococcus
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
12
12
2022
revised:
07
07
2023
accepted:
28
07
2023
medline:
4
9
2023
pubmed:
3
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Multidrug-resistant bacteria infect companion animals and livestock in addition to their devastating impact on human health. Novel Bacterial Topoisomerase Inhibitors (NBTIs) with excellent activity against Gram-positive bacteria have previously been identified as promising new antibacterial agents. Herein, we evaluate the antibacterial activity of these NBTIs against a variety of important veterinary pathogens and demonstrate outstanding in vitro activity, especially against staphylococci.
Identifiants
pubmed: 37531840
pii: S0378-1135(23)00192-X
doi: 10.1016/j.vetmic.2023.109840
pii:
doi:
Substances chimiques
Topoisomerase Inhibitors
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109840Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest MK, HAP, and JLW are employees and shareholders of Zoetis. MMF is a shareholder of Pfizer.