Microwave-activated Cu-doped zirconium metal-organic framework for a highly effective combination of microwave dynamic and thermal therapy.

Humans Metal-Organic Frameworks Microwaves Zirconium Reactive Oxygen Species / metabolism Liver Neoplasms
Cu-doped zirconium metal-organic framework (CuZr MOF) Ferroptosis Microwave thermal/dynamic therapy Reactive oxygen Synergistic antitumor therapy

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
09 2023
Historique:
received: 05 05 2023
revised: 27 06 2023
accepted: 28 07 2023
medline: 11 9 2023
pubmed: 3 8 2023
entrez: 2 8 2023
Statut: ppublish

Résumé

Percutaneous microwave ablation (PMA) is a thermoablative method used as a minimally invasive treatment for liver cancer. However, the application of PMA is limited by its insufficient ROS generation efficiency and thermal effects. Herein, a new microwave-activated Cu-doped zirconium metal-organic framework (MOF) (CuZr MOF) used for enhanced PMA has a significantly improved microwave sensitizing effect. Owing to the strong inelastic collisions between ions confined in numerous micropores, CuZr MOF has strong microwave sensitivity and high thermal conversion efficiency, which can significantly improve microwave thermal therapy (MTT). Moreover, because of the existence of Cu

Identifiants

DOI: 10.1016/j.jconrel.2023.07.046 PMID: 37532150
pubmed: 37532150
pii: S0168-3659(23)00470-4
doi: 10.1016/j.jconrel.2023.07.046
pii:
doi:

Substances chimiques

Metal-Organic Frameworks 0
Zirconium C6V6S92N3C
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102-114

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Yifu Feng (Y)

Department of Hepatobiliary, Taizhou Central Hospital, Taizhou University, Zhejiang 318000, China.

Qian Chen (Q)

Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.

Chong Jin (C)

Department of Hepatobiliary, Taizhou Central Hospital, Taizhou University, Zhejiang 318000, China.

Yanyun Ruan (Y)

Precision Medicine Center, Taizhou Central Hospital, Taizhou University, Taizhou, Zhejiang 318000, China.

Qi Chen (Q)

Precision Medicine Center, Taizhou Central Hospital, Taizhou University, Taizhou, Zhejiang 318000, China.

Weidong Lin (W)

Department of Hepatobiliary, Taizhou Central Hospital, Taizhou University, Zhejiang 318000, China.

Chumeng Zhu (C)

Precision Medicine Center, Taizhou Central Hospital, Taizhou University, Taizhou, Zhejiang 318000, China.

Tinglin Zhang (T)

Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200072, China.

Yang Zhang (Y)

Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Precision Medicine Center, Taizhou Central Hospital, Taizhou University, Taizhou, Zhejiang 318000, China. Electronic address: zhangyang0202@tongji.edu.cn.

Jie Gao (J)

Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200072, China. Electronic address: jmsx2021@shu.edu.cn.

Jinggang Mo (J)

Department of Hepatobiliary, Taizhou Central Hospital, Taizhou University, Zhejiang 318000, China. Electronic address: mojg@tzzxyy.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microwave-activated Cu-doped zirconium...
questionsmedicales.fr › Structures macromoléculaires › Réseaux organométalliques › Microwave-activated Cu-doped zirconium...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Ondes hertziennes › Micro-ondes › Microwave-activated Cu-doped zirconium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zirconium › Microwave-activated Cu-doped zirconium...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Microwave-activated Cu-doped zirconium...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Microwave-activated Cu-doped zirconium...