A quality improvement initiative for neonatal hypoglycemia screening and management in a level III neonatal intensive care unit.


Journal

Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 31 10 2022
accepted: 24 07 2023
revised: 07 07 2023
pubmed: 3 8 2023
medline: 3 8 2023
entrez: 2 8 2023
Statut: ppublish

Résumé

To bring screening and management of neonatal hypoglycemia in alignment with the 2011 AAP hypoglycemia clinical report METHODS: A multidisciplinary team developed a quality improvement initiative for neonatal hypoglycemia in neonates ≥35 weeks gestational age in a Level III neonatal intensive care unit between July 2020 and December 2021. A key driver diagram identified interventions for plan-do-study-act testing with corresponding measures to implement a hypoglycemia management protocol and improve adherence to AAP guidelines. Time to first blood glucose measurement increased from 49.8 to 122.7 min of life and time to first enteral feed decreased from 14.2 to 3.6 h of life. Neonates receiving intravenous dextrose decreased from 97.1 to 24.7% and discharge rates as a mother-neonate dyad increased from 35 to 62.4%. Adherence to the AAP guidelines improved during testing and implementation of a hypoglycemia protocol and was associated with an increased mother-neonate dyad discharge rate.

Identifiants

pubmed: 37532760
doi: 10.1038/s41372-023-01740-2
pii: 10.1038/s41372-023-01740-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1321-1329

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

Références

Hay WW, Raju TNK, Higgins RD, Kalhan SC, Devaskar SU. Knowledge gaps and research needs for understanding and treating neonatal hypoglycemia: workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development. J Pediatr. 2009;155:612–7.
doi: 10.1016/j.jpeds.2009.06.044 pubmed: 19840614
Thompson-Branch A, Havranek T. Neonatal Hypoglycemia. Pediatr Rev. 2017;38:147–57.
Ponnapakkam AP, Stine CN, Ahmad KA, Gallup MC, Delle Donne AJ, Kathen CM, et al. Evaluating the effects of a neonatal hypoglycemia bundle on NICU admission and exclusive breastfeeding. J Perinatol. 2020;40:344–51.
doi: 10.1038/s41372-019-0455-1 pubmed: 31395955
Oren MS, Barkhuff WD, Stefanescu A, Stefanescu BM, DuPont TL. The impact of the baby friendly hospital Initiative on neonatal hypoglycemia. J Perinatol. 2020;40:1828–33.
doi: 10.1038/s41372-020-00822-9 pubmed: 32963302
van Kempen AAMW, Eskes PF, Nuytemans DHGM, van der Lee JH, Dijksman LM, van Veenendaal NR, et al. Lower versus traditional treatment threshold for neonatal hypoglycemia. N Engl J Med. 2020;382:534–44.
doi: 10.1056/NEJMoa1905593 pubmed: 32023373
Vimalesvaran S, Kokotsis V, Akhtar F, Chetcuti-Ganado C. Improving the care of term babies at risk of hypoglycaemia: a microsystem approach. J Paediatr Child Health. 2021;57:835–40.
doi: 10.1111/jpc.15332 pubmed: 33426703
Adamkin DH, Committee on Fetus and Newborn. Postnatal glucose homeostasis in late-preterm and term infants. Pediatrics.2011;127:e20103851.
doi: 10.1542/peds.2010-3851
Harding JE, Hegarty JE, Crowther CA, Edlin RP, Gamble GD, Alsweiler JM, et al. Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia (hPOD): a multicenter, double-blind randomized controlled trial. PLoS Med. 2021;18:e1003411.
doi: 10.1371/journal.pmed.1003411 pubmed: 33507929 pmcid: 7842885
Harris DL, Weston PJ, Signal M, Chase JG, Harding JE. Dextrose gel for neonatal hypoglycaemia (the sugar babies study): a randomised, double-blind, placebo-controlled trial. Lancet. 2013;382:2077–83.
doi: 10.1016/S0140-6736(13)61645-1 pubmed: 24075361
Griffith R, Hegarty JE, Alsweiler JM, Gamble GD, May R, McKinlay CJD, et al. Two-year outcomes after dextrose gel prophylaxis for neonatal hypoglycaemia. Arch Dis Child Fetal Neonatal Ed. 2021;106:278–85.
doi: 10.1136/archdischild-2020-320305 pubmed: 33148686
Rawat M, Chandrasekharan P, Turkovich S, Barclay N, Perry K, Schroeder E, et al. Oral dextrose gel reduces the need for intravenous dextrose therapy in neonatal hypoglycemia. Biomed Hub. 2016;1:1–9.
doi: 10.1159/000448511 pubmed: 27840813 pmcid: 5104273
McKinlay CJD, Alsweiler JM, Ansell JM, Anstice NS, Chase JG, Gamble GD, et al. Neonatal glycemia and neurodevelopmental outcomes at 2 years. N Engl J Med. 2015;373:1507–18.
doi: 10.1056/NEJMoa1504909 pubmed: 26465984 pmcid: 4646166
Shah R, Harding J, Brown J, McKinlay C. Neonatal glycaemia and neurodevelopmental outcomes: a systematic review and meta-analysis. Neonatology. 2019;115:116–26.
doi: 10.1159/000492859 pubmed: 30408811
Harding JE, Harris DL, Hegarty JE, Alsweiler JM, McKinlay CJ. An emerging evidence base for the management of neonatal hypoglycaemia. Early Hum Dev. 2017;104:51–6.
doi: 10.1016/j.earlhumdev.2016.12.009 pubmed: 27989586
Edwards T, Alsweiler JM, Gamble GD, Griffith R, Lin L, McKinlay CJD, et al. Neurocognitive outcomes at age 2 years after neonatal hypoglycemia in a cohort of participants from the hPOD randomized trial. JAMA Netw Open. 2022;5:e2235989.
doi: 10.1001/jamanetworkopen.2022.35989 pubmed: 36219444 pmcid: 9554702
Rozance PJ, Wolfsdorf JI. Hypoglycemia in the newborn. Pediatr Clin North Am. 2019;66:333–42.
doi: 10.1016/j.pcl.2018.12.004 pubmed: 30819340
McKinlay CJD, Alsweiler JM, Anstice NS, Burakevych N, Chakraborty A, Chase JG, et al. Association of neonatal glycemia with neurodevelopmental outcomes at 4.5 years. JAMA Pediatr. 2017;171:972–83.
doi: 10.1001/jamapediatrics.2017.1579 pubmed: 28783802 pmcid: 5710616
Castrodale V, Rinehart S. The golden hour: improving the stabilization of the very low birth-weight infant. Adv Neonatal Care. 2014;14:9–14.
doi: 10.1097/ANC.0b013e31828d0289 pubmed: 24472882
Sharma D. Golden hour of neonatal life: need of the hour. Matern Health Neonatol Perinatol. 2017;3:16.
doi: 10.1186/s40748-017-0057-x pubmed: 28932408 pmcid: 5604187
Langley GJ, Moen RD, Nolan KM, Nolan TW, Norman CL, Provost LP. The Improvement Guide. 2nd ed. Chichester, England: Jossey Bass Wiley Publisher; 2009.
The Breakthrough Series: IHI’s Collaborative Model for Achieving Breakthrough Improvement | IHI - Institute for Healthcare Improvement [Internet]. Available from: https://www.ihi.org:443/resources/Pages/IHIWhitePapers/TheBreakthroughSeriesIHIsCollaborativeModelforAchievingBreakthroughImprovement.aspx . Accessed 4 Aug 2022.
Sen S, Cherkerzian S, Turner D, Monthé-Drèze C, Abdulhayoglu E, Zupancic JAF. A graded approach to intravenous dextrose for neonatal hypoglycemia decreases blood glucose variability, time in the neonatal intensive care unit, and cost of stay. J Pediatr. 2021;231:74–80.
doi: 10.1016/j.jpeds.2020.12.025 pubmed: 33338495
Harris DL, Gamble GD, Weston PJ, Harding JE. What happens to blood glucose concentrations after oral treatment for neonatal hypoglycemia? J Pediatr. 2017;190:136–41.
doi: 10.1016/j.jpeds.2017.06.034 pubmed: 28709629
Provost L. The Health Care Data Guide: Learning From Data for Improvement. San Francisco, CA: Jossey-Bass Publishers; 2011.
Healthcare Rules | IHI Rules | Control Chart Rules [Internet]. Available from: https://www.qimacros.com/control-chart/healthcare-rules/ . Accessed 7 Apr 2023.
Lloyd R. Quality Health Care: a guide to developing and using indicators. Sudbury, Mass.: Jones and Bartlett Publishers; 2019. p. 221.
Rozance PJ, Hay WW. New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol. 2016;2:3.
doi: 10.1186/s40748-016-0031-z pubmed: 27168942 pmcid: 4862061
Harris DL, Weston PJ, Gamble GD, Harding JE. Glucose profiles in healthy term infants in the first 5 days: The Glucose in Well Babies (GLOW) study. J Pediatr. 2020;223:34–41.e4.
doi: 10.1016/j.jpeds.2020.02.079 pubmed: 32381469
LeBlanc S, Haushalter J, Seashore C, Wood KS, Steiner MJ, Sutton AG. A quality-improvement initiative to reduce NICU transfers for neonates at risk for hypoglycemia. Pediatrics.2018;141:e20171143.
doi: 10.1542/peds.2017-1143 pubmed: 29437908
Sivarajan M, Schneider JH, Johnson KA, Bai S, ElHassan NO, Kaiser JR, et al. Decreasing early hypoglycemia frequency in at-risk newborns after implementing a new hypoglycemia screening algorithm. J Perinatol. 2021;41:2840–6.
doi: 10.1038/s41372-021-01263-8 pubmed: 34789816

Auteurs

Whitley N Hulse (WN)

Division of Neonatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. whulse@wisc.edu.
Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA. whulse@wisc.edu.

Krista Schulte (K)

University of Utah Hospital, Salt Lake City, UT, USA.

Victoria Eickelkamp-Marron (V)

Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.
University of Utah Hospital, Salt Lake City, UT, USA.

Hannah Redder (H)

University of Utah Hospital, Salt Lake City, UT, USA.

Jessica M Davidson (JM)

Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.

Belinda Chan (B)

Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.

Carrie Torr (C)

Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.

Tara L DuPont (TL)

Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.

Peter H Grubb (PH)

Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.

Classifications MeSH