Aerobic Exercise versus Electronic Cigarette in Vascular Aging Process: First Histological Insight.
Journal
International journal of vascular medicine
ISSN: 2090-2824
Titre abrégé: Int J Vasc Med
Pays: United States
ID NLM: 101542608
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
06
2023
revised:
03
07
2023
accepted:
07
07
2023
medline:
3
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
epublish
Résumé
Smoking is related to vascular aging. However, the hazardous effect of e-cigarette is often debatable, with limited studies available. In contrast, moderate-intensity aerobic exercise is well known to decrease aortic stiffness. We provide novel research to determine the effect of e-cigarette and aerobic moderate-intensity exercise on the aortic structure of Wistar rats. A total of 26 male Wistar rats (Rattus norvegicus) 8 weeks aged, 200-250 g b.w., were randomly divided into 4 groups, namely, K0 (normal rats), K1 (rats were given moderate-intensity aerobic exercise by animal treadmill 20 m/30 min), K2 (rats were given e-cigarette with 6 mg nicotine, 40% propylene glycol, and 60% vegetable glycerine 30 min for 5 days/week), and K3 (rats were given e-cigarette and moderate-intensity aerobic exercise). After exposure for 6 weeks, all animals were sacrificed to isolate the aorta for histopathological analysis with hematoxylin-eosin stain to evaluate the elastic fiber layer and intimal-medial thickness. The Verhoeff-Van Gieson staining was done for quantification elastic lamina fragmentation. Our study found that the e-cigarette group had the highest elastic lamina fragmentation among groups (8.14 ± 2.85). The exercise only group showed the lowest elastic lamina fragmentation (2.50 ± 1.87). Fragmentation in the e-cigarette and exercise group was higher than in the exercise only group (5.83 ± 0.753 vs. 2.50 ± 1.87,
Identifiants
pubmed: 37533734
doi: 10.1155/2023/8874599
pmc: PMC10393525
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8874599Informations de copyright
Copyright © 2023 Vito A. Damay et al.
Déclaration de conflit d'intérêts
There is no conflict of interest in this study.
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