Mesenchymal stem cells and connective tissue diseases: From bench to bedside.
connective tissue diseases
mesenchymal stem cells
rheumatoid arthritis
systemic lupus erythematosus
translational medicine
treatment
Journal
Journal of translational internal medicine
ISSN: 2450-131X
Titre abrégé: J Transl Int Med
Pays: Poland
ID NLM: 101673826
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
medline:
3
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
epublish
Résumé
The pathogenesis of connective tissue diseases (CTDs), represented by systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS), and idiopathic inflammatory myopathies (IIM), includes various immune cells involved in both innate and adaptive immunity. The mesenchymal stem cells (MSCs) are unique due to their regulatory effect on immunity. This makes them a promising therapeutic approach for patients with immune-mediated disorders such as CTD. The safety and clinical efficacy of MSC treatment in CTD have been tested in a growing number of preclinical and clinical studies. Administration of MSCs has consistently shown benefits with both symptomatic and histologic improvement in CTD animal models. MSC therapies in severe and drug-resistant CTD patients have shown promise in a number of the pilot studies, cohort studies, and randomized controlled trials in SLE, RA, and SSc, but some problems still need to be resolved in the transition from the bench to the bedside. The relevant studies in pSS and IIM are still in their infancy, but have displayed encouraging outcomes. Considerable efficacy variations have been observed in terms of the route of delivery, time of MSC injection, origin of the MSCs and dosage. Furthermore, the optimization of conventional drugs combined with MSC therapies and the applications of novel cell engineering approaches requires additional research. In this review, we summarize the current evidence about the immunoregulatory mechanism of MSCs, as well as the preclinical and clinical studies of MSC-based therapy for the treatment of CTDs.
Identifiants
pubmed: 37533846
doi: 10.2478/jtim-2022-0028
pii: jtim-2022-0028
pmc: PMC10393058
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30-45Informations de copyright
© 2023 Yue Shi, Nan Jiang, Mengtao Li, Xiaofeng Zeng, Xinping Tian, published by Sciendo.
Déclaration de conflit d'intérêts
Conflict of Interest The authors have no conflicts of interest to disclose.
Références
Arthritis Res Ther. 2016 Apr 01;18:77
pubmed: 27036118
Lupus. 2018 Nov;27(13):2161-2165
pubmed: 30290717
Ann Rheum Dis. 2012 Oct;71(10):1733-40
pubmed: 22586171
J Formos Med Assoc. 2021 Jan;120(1 Pt 3):602-608
pubmed: 32718891
Stem Cells Int. 2016;2016:4062789
pubmed: 28053607
Stem Cell Reports. 2017 Mar 14;8(3):743-757
pubmed: 28216148
Blood. 2012 Oct 11;120(15):3142-51
pubmed: 22927248
Stem Cells Int. 2015;2015:583984
pubmed: 26064137
Cell Transplant. 2013;22(12):2267-77
pubmed: 24388428
Drug Des Devel Ther. 2021 Sep 15;15:3927-3936
pubmed: 34584402
Cytotherapy. 2018 Apr;20(4):499-506
pubmed: 29428486
Cell Transplant. 2011;20(2):245-57
pubmed: 20719085
Stem Cell Reports. 2018 Mar 13;10(3):933-941
pubmed: 29478901
Bone Marrow Transplant. 2013 Apr;48(4):544-50
pubmed: 23064040
J Autoimmun. 2016 Jun;70:31-9
pubmed: 27052182
Stem Cell Res Ther. 2020 Feb 4;11(1):48
pubmed: 32019582
Biomed Pharmacother. 2019 Jan;109:1834-1840
pubmed: 30551438
World J Stem Cells. 2012 Oct 26;4(10):101-9
pubmed: 23189211
Ann Rheum Dis. 2011 Nov;70(11):2011-21
pubmed: 21821866
Aging (Albany NY). 2016 May;8(5):1102-14
pubmed: 27048648
Front Immunol. 2019 Mar 04;10:266
pubmed: 30886614
Cell Transplant. 2013;22(12):2279-90
pubmed: 23127285
EBioMedicine. 2018 Jun;32:21-30
pubmed: 29885865
Nephrol Dial Transplant. 2019 Apr 1;34(4):597-605
pubmed: 29982691
J Invest Dermatol. 2017 Jun;137(6):1223-1233
pubmed: 28132855
Cell Death Dis. 2016 Dec 22;7(12):e2524
pubmed: 28005072
Ann Rheum Dis. 2017 Jan;76(1):196-202
pubmed: 27269294
Ann Rheum Dis. 2018 Mar;77(3):e14
pubmed: 28611081
J Immunol Res. 2015;2015:183738
pubmed: 26090483
Stem Cells Int. 2020 Mar 5;2020:5617192
pubmed: 32215018
Stem Cell Res Ther. 2017 Jul 14;8(1):168
pubmed: 28705238
Cell Metab. 2015 Oct 6;22(4):606-18
pubmed: 26365178
J Am Soc Nephrol. 2020 Jan;31(1):54-65
pubmed: 31604808
Arthritis Rheum. 2007 Apr;56(4):1175-86
pubmed: 17393437
Stem Cell Res Ther. 2016 Nov 10;7(1):163
pubmed: 27832825
EBioMedicine. 2019 Sep;47:563-577
pubmed: 31501076
Stem Cell Res Ther. 2021 May 29;12(1):314
pubmed: 34051857
Cells. 2019 Aug 03;8(8):
pubmed: 31382595
Rheumatology (Oxford). 2014 May;53(5):854-9
pubmed: 24390937
Blood. 2011 Jul 14;118(2):330-8
pubmed: 21551236
Arthritis Rheum. 2009 Apr;60(4):1006-19
pubmed: 19333946
Stem Cells Dev. 2013 Dec 15;22(24):3192-202
pubmed: 23941289
Stem Cells Dev. 2015 Sep 15;24(18):2091-100
pubmed: 26068030
Stem Cells Transl Med. 2018 Sep;7(9):636-642
pubmed: 30112846
Arthritis Rheum. 2011 Aug;63(8):2540-2
pubmed: 21547891
Autoimmun Rev. 2015 Jan;14(1):43-8
pubmed: 25308529
Sci Rep. 2016 Dec 07;6:38237
pubmed: 27924862
Arthritis Rheumatol. 2014 Aug;66(8):2234-45
pubmed: 24756936
Sci Rep. 2016 Dec 02;6:38308
pubmed: 27910911
Rheumatology (Oxford). 2015 Jan;54(1):163-8
pubmed: 25065014
Front Cell Dev Biol. 2020 Mar 13;8:131
pubmed: 32232043
Arthritis Res Ther. 2010;12(6):R210
pubmed: 21080925
Stem Cells. 2008 Feb;26(2):562-9
pubmed: 18024418
Rheumatology (Oxford). 2007 May;46(5):882-4
pubmed: 17309890
Stem Cell Res Ther. 2018 Aug 9;9(1):208
pubmed: 30092847
Arthritis Rheum. 2013 May;65(5):1181-93
pubmed: 23400582
Exp Ther Med. 2020 Dec;20(6):257
pubmed: 33199983
Stem Cell Res Ther. 2021 Jun 5;12(1):327
pubmed: 34090522
J Immunol. 2014 Nov 15;193(10):5306-14
pubmed: 25339674
Theranostics. 2018 Feb 3;8(5):1399-1410
pubmed: 29507629
J Tissue Eng Regen Med. 2019 Jul;13(7):1134-1142
pubmed: 30959558
Lupus. 2020 Feb;29(2):126-135
pubmed: 31870216
J Immunol Res. 2020 Apr 28;2020:3562753
pubmed: 32411794
Blood. 2005 May 15;105(10):4120-6
pubmed: 15692068
Ann Rheum Dis. 2011 Jul;70(7):1285-8
pubmed: 21622775
Stem Cell Res Ther. 2018 Jun 19;9(1):168
pubmed: 29921311
Arthritis Rheum. 2012 Jan;64(1):243-53
pubmed: 21904997
Int J Rheum Dis. 2020 Feb;23(2):216-225
pubmed: 31808305
Arthritis Rheum. 2010 Sep;62(9):2776-86
pubmed: 20496367
Cell Mol Immunol. 2017 May;14(5):423-431
pubmed: 26435067
Arthritis Rheumatol. 2014 Jul;66(7):1955-60
pubmed: 24692225
Stem Cells Int. 2019 May 2;2019:7061408
pubmed: 31191681
Clin Exp Med. 2017 Aug;17(3):333-340
pubmed: 27270729
Ann Rheum Dis. 2017 Aug;76(8):1436-1439
pubmed: 28478399
Stem Cells Transl Med. 2017 Sep;6(9):1777-1785
pubmed: 28755405
J Immunol. 2014 Nov 1;193(9):4381-90
pubmed: 25274529
Stem Cell Res Ther. 2012 Oct 19;3(5):40
pubmed: 23083975
Clin Immunol. 2018 Aug;193:38-45
pubmed: 29373844
Stem Cells. 2009 Jun;27(6):1421-32
pubmed: 19489103
Front Immunol. 2019 Feb 05;10:18
pubmed: 30804924
Stem Cell Res Ther. 2015 May 27;6:104
pubmed: 26012584
Rheumatology (Oxford). 2020 Jun 1;59(6):1426-1438
pubmed: 31904843
Sci Rep. 2018 Jan 11;8(1):427
pubmed: 29323140
Arthritis Rheum. 2011 Jun;63(6):1668-80
pubmed: 21384335
Osteoarthritis Cartilage. 2017 Sep;25(9):1541-1550
pubmed: 28545880
J Transl Med. 2018 Jun 15;16(1):165
pubmed: 29903026
J Transl Med. 2020 Sep 1;18(1):336
pubmed: 32873307
Stem Cells Transl Med. 2013 May;2(5):362-75
pubmed: 23592838
J Clin Med. 2020 Sep 19;9(9):
pubmed: 32961802
Blood. 2009 Jan 1;113(1):46-57
pubmed: 18832657
J Transl Med. 2011 Oct 21;9:181
pubmed: 22017805
Stem Cells. 2008 Jan;26(1):212-22
pubmed: 17932417
Nat Med. 2009 Jan;15(1):42-9
pubmed: 19098906
Drug Des Devel Ther. 2019 Dec 19;13:4331-4340
pubmed: 31908418
Arthritis Res Ther. 2010;12(1):R31
pubmed: 20175883
Front Immunol. 2021 Feb 24;12:643170
pubmed: 33732263
Stem Cells Int. 2017;2017:3134543
pubmed: 28348600
Cell Transplant. 2015;24(11):2297-305
pubmed: 25506730
Stem Cell Res Ther. 2018 Nov 14;9(1):312
pubmed: 30428931
Front Immunol. 2020 Dec 22;11:604607
pubmed: 33414787
Mol Ther. 2020 Nov 4;28(11):2417-2429
pubmed: 32707035
Arthritis Res Ther. 2014 Mar 25;16(2):R79
pubmed: 24661633
Ann Rheum Dis. 2020 Oct;79(10):1298-1304
pubmed: 32561603
Arthritis Rheum. 2010 Aug;62(8):2467-75
pubmed: 20506343
J Autoimmun. 2020 Sep;113:102491
pubmed: 32565049
Cell Mol Immunol. 2016 May;13(3):401-8
pubmed: 26388237
J Cell Biochem. 2015 Aug;116(8):1583-94
pubmed: 25649549
Arthritis Res Ther. 2017 Jul 19;19(1):165
pubmed: 28724445
J Dent Res. 2013 Jul;92(7):609-15
pubmed: 23697344
Ann Rheum Dis. 2010 Aug;69(8):1423-9
pubmed: 20650877
Int J Mol Med. 2014 Sep;34(3):695-704
pubmed: 24970492
Stem Cells. 2015 Dec;33(12):3493-503
pubmed: 26205964
Cell Mol Immunol. 2019 Mar;16(3):260-274
pubmed: 30886422
Arthritis Res Ther. 2012 Jul 19;14(4):R167
pubmed: 22812502
Nat Commun. 2019 Jun 7;10(1):2498
pubmed: 31175312
Front Immunol. 2018 Nov 05;9:2571
pubmed: 30455706
Theranostics. 2021 Jan 1;11(2):893-905
pubmed: 33391511
Arthritis Rheum. 2005 May;52(5):1595-603
pubmed: 15880818
Arthritis Rheumatol. 2017 Aug;69(8):1623-1635
pubmed: 28471483
EBioMedicine. 2019 Jul;45:341-350
pubmed: 31248835
Stem Cells Int. 2021 Apr 5;2021:6665601
pubmed: 33884000