Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression.
Cell biology
Molecular physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
20
03
2023
revised:
01
05
2023
accepted:
25
05
2023
medline:
3
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
epublish
Résumé
The nuclear receptor peroxisome proliferator activated receptor-γ (PPARγ) is a key contributor to metabolic function via its adipogenic and insulin-sensitizing functions, but it has negative effects on skeletal homeostasis. Here, we questioned whether the skeletal and metabolic actions of PPARγ are linked. Ablating
Identifiants
pubmed: 37534168
doi: 10.1016/j.isci.2023.106999
pii: S2589-0042(23)01076-3
pmc: PMC10391670
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106999Subventions
Organisme : BLRD VA
ID : I01 BX003724
Pays : United States
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
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