Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal.
Biochemistry
Cell biology
Molecular biology
Neurology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
21
11
2022
revised:
01
05
2023
accepted:
05
06
2023
medline:
3
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
epublish
Résumé
Within the adult mammalian dentate gyrus (DG) of the hippocampus, glutamate stimulates neural stem cell (NSC) self-renewing proliferation, providing a link between adult neurogenesis and local circuit activity. Here, we show that glutamate-induced self-renewal of adult DG NSCs requires glutamate transport via excitatory amino acid transporter 1 (EAAT1) to stimulate lipogenesis. Loss of EAAT1 prevented glutamate-induced self-renewing proliferation of NSCs
Identifiants
pubmed: 37534178
doi: 10.1016/j.isci.2023.107068
pii: S2589-0042(23)01145-8
pmc: PMC10391730
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107068Subventions
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS123797
Pays : United States
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
V.V. is currently a consultant for Antec Scientific, USA, a role acquired in Oct 2019 after the completion of the relevant uHPLC-ECD studies but before the writing of the manuscript. The remaining authors declare no competing interests.
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