Celiac disease in paediatric patients in the United Arab Emirates: a single-center descriptive study.
United Arab Emirates
celiac
celiac disease
gluten
pediatric patients
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
03
2023
accepted:
27
06
2023
medline:
3
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
epublish
Résumé
Celiac disease (CD) is an autoimmune disorder that is provoked by the consumption of gluten in genetically vulnerable individuals. CD affects individuals worldwide with an estimated prevalence of 1% and can manifest at any age. Growth retardation and anemia are common presentations in children with CD. The objective of this study is to estimate the prevalence of CD in multiple "at risk groups" and to characterize children with CD, presented to a tertiary hospital in Dubai, United Arab Emirates (UAE). The study reviewed medical charts of all patients <18 years who had received serologic testing for CD. The study was conducted at Al Jalila Children's Specialty Hospital in Dubai, UAE, from January 2018 to July 2021. Extracted information from medical records included sociodemographics, laboratory findings, clinical presentation, and any associated co-morbidities. The European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) criteria were used to identify patients with CD. During the study period, 851 paediatric patients underwent serological screening for CD, out of which, 23 (2.7%) were confirmed with CD. Of the 23 patients diagnosed with CD, 43.5% had no gastrointestinal symptoms. Diabetes type 1 (30.4%) followed by iron deficiency anaemia (30%) and Hashimoto thyroiditis (9%) were the most commonly associated comorbidities. The prevalence of CD among paediatric patients with autoimmune thyroiditis (12.5%) was 1.92-times higher than that among paediatric patients with diabetes type 1 (6.5%). The results of this study show that almost three out of every 100 paediatric patients who were screened for CD were confirmed to have the condition. These findings highlight the importance of screening children who are at risk or present symptoms suggestive of CD, to ensure early diagnosis and appropriate management.
Identifiants
pubmed: 37534197
doi: 10.3389/fped.2023.1197612
pmc: PMC10391541
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1197612Informations de copyright
© 2023 AlNababteh, Tzivinikos, Al-Shamsi, Govender and Al-Rifai.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Am J Gastroenterol. 2020 Apr;115(4):507-525
pubmed: 32022718
Am J Gastroenterol. 2002 Aug;97(8):2051-7
pubmed: 12190176
J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):432-437
pubmed: 28151767
J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):156-65
pubmed: 27035374
BMJ. 2015 Sep 02;351:h4513
pubmed: 26333593
Saudi Med J. 2017 Sep;38(9):895-899
pubmed: 28889146
Adv Data. 2000 Jun 8;(314):1-27
pubmed: 11183293
Saudi J Gastroenterol. 2015 Nov-Dec;21(6):367-71
pubmed: 26655131
Epilepsy Behav. 2019 Oct;99:106393
pubmed: 31479999
J Pediatr Endocrinol Metab. 2009 Oct;22(10):979-83
pubmed: 20020588
Aliment Pharmacol Ther. 2021 Jul;54(2):109-128
pubmed: 34115894
Front Neuroendocrinol. 2014 Aug;35(3):347-69
pubmed: 24793874
Dig Dis. 2015;33(2):147-154
pubmed: 25925916
Am J Med. 2006 Apr;119(4):355.e9-14
pubmed: 16564784
J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):141-156
pubmed: 31568151
Gut. 1987 Dec;28(12):1595-9
pubmed: 3428686
Diseases. 2015 Jun 16;3(2):86-101
pubmed: 28943611
BMC Med. 2019 Jul 23;17(1):142
pubmed: 31331324
Nutrients. 2021 Dec 21;14(1):
pubmed: 35010880
Acta Biomed. 2018 Dec 17;89(9-S):5-10
pubmed: 30561389
BMC Pediatr. 2020 May 27;20(1):256
pubmed: 32460713
World J Clin Pediatr. 2021 Jul 9;10(4):53-71
pubmed: 34316439
J Pediatr Gastroenterol Nutr. 2021 Jun 1;72(6):894-899
pubmed: 33908739
Chin Med J (Engl). 2020 Mar 20;(6):729-731
pubmed: 32197032
Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2
pubmed: 29551598
World J Gastroenterol. 2010 Mar 28;16(12):1449-57
pubmed: 20333784
World J Gastroenterol. 2022 Aug 28;28(32):4493-4507
pubmed: 36157923
Aliment Pharmacol Ther. 2014 Nov;40(10):1123-32
pubmed: 25270960
J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):1-19
pubmed: 15625418
Thyroid. 2016 Jul;26(7):880-90
pubmed: 27256300
J Pediatr. 2016 Jul;174:146-152.e1
pubmed: 27021409
Best Pract Res Clin Gastroenterol. 2005 Jun;19(3):467-78
pubmed: 15925850
World J Gastroenterol. 2013 Apr 21;19(15):2374-8
pubmed: 23613632
Biomed Pharmacother. 2000 Aug;54(7):368-72
pubmed: 10989975
J Pediatr. 2013 Jul;163(1):237-42
pubmed: 23399451
Clin Exp Pediatr. 2021 Jun;64(6):301-309
pubmed: 33091973
Gastroenterology. 2021 Jan;160(1):63-75
pubmed: 32950520
Sci Rep. 2021 Jan 27;11(1):2383
pubmed: 33504878
J Diabetes. 2021 Jun;13(6):448-457
pubmed: 33118261
Nat Rev Gastroenterol Hepatol. 2015 Oct;12(10):561-71
pubmed: 26260366
Clin Immunol Immunopathol. 1997 Sep;84(3):223-43
pubmed: 9281381
Saudi J Gastroenterol. 2012 Jan-Feb;18(1):23-5
pubmed: 22249088
BMC Pediatr. 2014 Jun 30;14:165
pubmed: 24981433
Adv Pediatr. 2008;55:349-65
pubmed: 19048738
J Autoimmun. 2014 Aug;52:146-53
pubmed: 24361103
Semin Immunopathol. 2012 Jul;34(4):473-8
pubmed: 22526468
J Pediatr Gastroenterol Nutr. 2017 Dec;65(6):646-651
pubmed: 28753180