Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against

Chagas disease Immunogenicity

Journal

Current research in immunology
ISSN: 2590-2555
Titre abrégé: Curr Res Immunol
Pays: Netherlands
ID NLM: 101776898

Informations de publication

Date de publication:
2023
Historique:
received: 05 12 2022
revised: 30 06 2023
accepted: 06 07 2023
medline: 3 8 2023
pubmed: 3 8 2023
entrez: 3 8 2023
Statut: epublish

Résumé

Tc24 is a

Identifiants

pubmed: 37534309
doi: 10.1016/j.crimmu.2023.100066
pii: S2590-2555(23)00012-4
pmc: PMC10393535
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100066

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Institutional reports financial support was provided by 10.13039/100012394Robert J Kleberg Jr and Helen C Kleberg Foundation. All Authors are part of a team of scientists advancing research towards the development of a therapeutic Chagas disease vaccine. MEB and PJH are listed among the inventors on a Chagas disease vaccine patent, submitted by Baylor College of Medicine. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the review article apart from those disclosed.

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Auteurs

Cristina Poveda (C)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Ana Carolina Leão (AC)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Chiara Mancino (C)

Center for Musculoskeletal Regeneration, Houston Methodist Research Institute, Houston, TX, USA.
Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston, TX, USA.

Francesca Taraballi (F)

Center for Musculoskeletal Regeneration, Houston Methodist Research Institute, Houston, TX, USA.
Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston, TX, USA.

Yi-Lin Chen (YL)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Rakesh Adhikari (R)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Maria Jose Villar (MJ)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Rakhi Kundu (R)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Duc M Nguyen (DM)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

Leroy Versteeg (L)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Cell Biology and Immunology Group, Wageningen University & Research, the Netherlands.

Ulrich Strych (U)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Peter J Hotez (PJ)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Department of Biology, Baylor University, Waco, TX, USA.

Maria Elena Bottazzi (ME)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Department of Biology, Baylor University, Waco, TX, USA.

Jeroen Pollet (J)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Kathryn M Jones (KM)

Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.

Classifications MeSH