Periprosthetic Joint Infections of the Knee Lastingly Impact the Bone Homeostasis.
BIOCHEMICAL MARKERS OF BONE TURNOVER
BONE μCT
IMPLANTS
OSTEOBLASTS
OSTEOCLASTS
PERIPROSTHETIC JOINT INFECTION
REVISION ARTHROPLASTY
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
26
07
2023
received:
04
05
2023
accepted:
01
08
2023
pubmed:
3
8
2023
medline:
3
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
After periprosthetic joint infection (PJI)-dependent revision surgery, a significantly elevated number of patients suffer from prosthesis failure due to aseptic loosening and require additional revision surgery despite clearance of the initial infection. The mechanisms underlying this pathology are not well understood, as it has been assumed that the bone stock recovers after revision surgery. Despite clinical evidence suggesting decreased osteogenic potential in PJI, understanding of the underlying biology remains limited. In this study, we investigated the impact of PJI on bone homeostasis in a two-stage exchange approach at explantation and reimplantation. Sixty-four human tibial and femoral specimens (20 control, 20 PJI septic explantation, and 24 PJI prosthesis reimplantation samples) were analyzed for their bone microstructure, cellular composition, and expression of relevant genetic markers. Samples were analyzed using X-ray microtomography, Alcian blue and tartrate-resistant acid phosphatase staining, and RT-qPCR. In patients with PJI, bone volume (BV/TV; 0.173 ± 0.026; p < 0.001), trabecular thickness (164.262 ± 18.841 μm; p < 0.001), and bone mineral density (0.824 ± 0.017 g/cm
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1472-1479Subventions
Organisme : Berlin Institute of Health
Organisme : Deutschen Arthrose-Hilfe
ID : P482
Organisme : Charite Universitatsmedizin Berlin
Informations de copyright
© 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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