Prospective use of molecular minimal residual disease for risk stratification in children and adolescents with acute lymphoblastic leukemia : Long-term results of the AIEOP-BFM ALL 2000 trial in Austria.

Acute lymphoblastic leukemia Minimal residual disease Outcome Prognosis Stratification

Journal

Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R

Informations de publication

Date de publication:
03 Aug 2023
Historique:
received: 29 05 2023
accepted: 28 06 2023
medline: 3 8 2023
pubmed: 3 8 2023
entrez: 3 8 2023
Statut: aheadofprint

Résumé

Since 1979 Austrian children and adolescents with acute lymphoblastic leukemia (ALL) have been treated according to protocols of the Berlin-Frankfurt-Münster (BFM) study group. The Associazione Italiana di Ematologia e Oncologia Pediatrica and BFM (AIEOP-BFM) ALL 2000 study was designed to prospectively study patient stratification into three risk groups using minimal residual disease (MRD) on two time points during the patient's early disease course. The MRD levels were monitored by detection of clone-specific rearrangements of the immunoglobulin and T‑cell receptor genes applying a quantitative polymerase chain reaction-based technique. The 7‑year event-free survival (EFS) and overall survival rates for all 608 Austrian patients treated between June 1999 and December 2009 within the AIEOP-BFM 2000 study were 84 ± 2% and 91 ± 1%, respectively, with a median observation time of 6.58 years. Event-free survival for patients with precursor B‑cell and T‑cell ALL were 84 ± 2% (n = 521) and 84 ± 4% (n = 87; p = 0.460), respectively. The MRD assessment was feasible in 94% of the patients and allowed the definition of precursor B‑cell ALL patients with a low, intermediate or high risk of relapse even on top of clinically relevant subgroups. A similar finding with respect to MRD relevance in T‑ALL patients was not possible due to the small number of patients and events. Since this pivotal international AIEOP-BFM ALL 2000 trial, molecular response to treatment has been continuously used with additional refinements to stratify patients into different risk groups in all successive trials of the AIEOP-BFM ALL study group.

Identifiants

pubmed: 37535134
doi: 10.1007/s00508-023-02249-6
pii: 10.1007/s00508-023-02249-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : St. Anna CCRI

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

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Auteurs

Leila Ronceray (L)

Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Kinderspitalgasse 6, 1090, Vienna, Austria.

Michael Dworzak (M)

Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Kinderspitalgasse 6, 1090, Vienna, Austria.
St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Karin Dieckmann (K)

Department of Radiotherapy, Medical University of Vienna, Vienna, Austria.

Georg Ebetsberger-Dachs (G)

Department of Pediatrics and Adolescent Medicine, Kepler University Hospital Linz, Linz, Austria.

Evgenia Glogova (E)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Oskar A Haas (OA)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Labdia Labordiagnostik, Vienna, Austria.

Neil Jones (N)

Department of Pediatrics and Adolescent Medicine, University Clinics Salzburg, Salzburg, Austria.

Karin Nebral (K)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Labdia Labordiagnostik, Vienna, Austria.

Reinhard Moser (R)

Department of Pediatrics and Adolescent Medicine, State Hospital Leoben, Leoben, Austria.

Thomas Lion (T)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Labdia Labordiagnostik, Vienna, Austria.

Bernhard Meister (B)

Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.

Renate Panzer-Grümayer (R)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Sabine Strehl (S)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Christina Peters (C)

Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Kinderspitalgasse 6, 1090, Vienna, Austria.

Ulrike Pötschger (U)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Christian Urban (C)

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

Georg Mann (G)

Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Kinderspitalgasse 6, 1090, Vienna, Austria.
St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Andishe Attarbaschi (A)

Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Kinderspitalgasse 6, 1090, Vienna, Austria. andishe.attarbaschi@stanna.at.
St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. andishe.attarbaschi@stanna.at.

Classifications MeSH