Humans Chemokine CXCL9 / analysis Head and Neck Neoplasms / immunology Macrophages / immunology Osteopontin / analysis Prognosis Squamous Cell Carcinoma of Head and Neck / immunology Tumor Microenvironment Cell Polarity / immunology

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
04 08 2023
Historique:
medline: 7 8 2023
pubmed: 3 8 2023
entrez: 3 8 2023
Statut: ppublish

Résumé

Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and neck squamous cell carcinomas. We found that macrophage polarity-defined by

Identifiants

DOI: 10.1126/science.ade2292 PMID: 37535729
pubmed: 37535729
doi: 10.1126/science.ade2292
doi:

Substances chimiques

Chemokine CXCL9 0
CXCL9 protein, human 0
Osteopontin 106441-73-0
SPP1 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

515-524

Subventions

Organisme : NCI NIH HHS
ID : P01 CA240239
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123349
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI163223
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA257623
Pays : United States

Auteurs

Ruben Bill (R)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
ORCID: 0000-0002-4674-2531

Pratyaksha Wirapati (P)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
ORCID: 0000-0002-0327-4686

Marius Messemaker (M)

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
ORCID: 0000-0002-7179-0594

Whijae Roh (W)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
ORCID: 0000-0002-7395-9939

Beatrice Zitti (B)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
ORCID: 0000-0003-4610-7535

Florent Duval (F)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
ORCID: 0000-0002-3652-184X

Máté Kiss (M)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
ORCID: 0000-0002-5649-0382

Jong Chul Park (JC)

Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
ORCID: 0000-0002-1052-0734

Talia M Saal (TM)

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-5472-2143

Jan Hoelzl (J)

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany.
ORCID: 0000-0002-6411-7422

David Tarussio (D)

Swiss Cancer Center Leman, Lausanne, Switzerland.
Department of Oncology, Center for Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne, Switzerland.

Fabrizio Benedetti (F)

Department of Oncology, Center for Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne, Switzerland.
ORCID: 0000-0002-9959-9142

Stéphanie Tissot (S)

Swiss Cancer Center Leman, Lausanne, Switzerland.
Department of Oncology, Center for Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne, Switzerland.
ORCID: 0000-0003-3080-4598

Lana Kandalaft (L)

AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
Department of Oncology, Center for Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne, Switzerland.
ORCID: 0000-0002-1575-6674

Marco Varrone (M)

Swiss Cancer Center Leman, Lausanne, Switzerland.
Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
ORCID: 0000-0002-0538-3464

Giovanni Ciriello (G)

AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
ORCID: 0000-0003-2021-8683

Thomas A McKee (TA)

Division of Clinical Pathology, Diagnostic Department, Geneva University Hospitals (HUG), Geneva, Switzerland.
ORCID: 0000-0002-2147-3136

Yan Monnier (Y)

Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.

Maxime Mermod (M)

Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.
ORCID: 0000-0001-5330-3097

Emily M Blaum (EM)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
ORCID: 0000-0002-8656-8216

Irena Gushterova (I)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
ORCID: 0000-0002-8405-6348

Anna L K Gonye (ALK)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
ORCID: 0000-0003-0034-1756

Nir Hacohen (N)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
ORCID: 0000-0002-2349-2656

Gad Getz (G)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-0936-0753

Thorsten R Mempel (TR)

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0001-8635-5424

Allon M Klein (AM)

Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-8913-7879

Ralph Weissleder (R)

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0003-0828-4143

William C Faquin (WC)

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9043-7171

Peter M Sadow (PM)

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-1036-6367

Derrick Lin (D)

Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
ORCID: 0009-0000-5022-3438

Sara I Pai (SI)

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Moshe Sade-Feldman (M)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
ORCID: 0000-0002-0022-0287

Mikael J Pittet (MJ)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Ludwig Institute for Cancer Research, Lausanne, Switzerland.
Department of Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland.
ORCID: 0000-0002-2060-4691

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL9 ›
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou ›
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages ›
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Ostéopontine ›
questionsmedicales.fr › Diagnostic › Pronostic ›
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou ›
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral ›
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Polarité de la cellule ›