Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 08 2023
24 08 2023
Historique:
medline:
25
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
The design and synthesis of a series of 2,7-diazaspiro[4.4]nonane derivatives as potent sigma receptor (SR) ligands, associated with analgesic activity, are the focus of this work. In this study, affinities at S1R and S2R were measured, and molecular modeling studies were performed to investigate the binding pose characteristics. The most promising compounds were subjected to
Identifiants
pubmed: 37535861
doi: 10.1021/acs.jmedchem.3c00959
pmc: PMC10461227
doi:
Substances chimiques
Ligands
0
Receptors, sigma
0
Analgesics
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
11447-11463Subventions
Organisme : NEI NIH HHS
ID : R01 EY029409
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS124784
Pays : United States
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