Liver Pathology After Hematopoietic Stem Cell Transplantation.

Graft-versus-host disease Infection Iron overload Liver Sinusoidal obstruction syndrome Stem cell transplant Veno-occlusive disease

Journal

Surgical pathology clinics
ISSN: 1875-9157
Titre abrégé: Surg Pathol Clin
Pays: United States
ID NLM: 101491209

Informations de publication

Date de publication:
Sep 2023
Historique:
medline: 7 8 2023
pubmed: 4 8 2023
entrez: 3 8 2023
Statut: ppublish

Résumé

Hematopoietic stem cell transplantation is used to treat a variety of hematologic malignancies and autoimmune conditions. The immunosuppressive medications as well as other therapies used both before and after transplantation leave patients susceptible to a wide spectrum of complications, including liver injury. Causes for liver damage associated with stem cell transplantation include sinusoidal obstruction syndrome, graft-versus-host disease, iron overload, and opportunistic infection. Here, the authors review the clinical and pathological findings of these etiologies of liver injury and provide a framework for diagnosis.

Identifiants

pubmed: 37536886
pii: S1875-9181(23)00033-8
doi: 10.1016/j.path.2023.04.007
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

519-532

Subventions

Organisme : NCATS NIH HHS
ID : KL2 TR003143
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Ragini Phansalkar (R)

Department of Pathology, Lane Building, L235, 300 Pasteur Drive, Stanford, CA 94305, USA.

Neeraja Kambham (N)

Department of Pathology, Lane Building, L235, 300 Pasteur Drive, Stanford, CA 94305, USA.

Vivek Charu (V)

Department of Pathology, Lane Building, L235, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Medicine, Quantitative Sciences Unit, Stanford, CA, USA. Electronic address: vcharu@stanford.edu.

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Classifications MeSH